Help
Options
Didn't know it?
click below
click below
Knew it?
click below
click below
Don't Know
Remaining cards (0)
Know
retry
shuffle
restart
0:00
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.
Normal Size Small Size show me how
Normal Size Small Size show me how
DU PA SLE
Duke PA Systemic Lupus Erythematosus
| Question | Answer |
|---|---|
| with SLE any __ can be involved | organ system |
| cells and organs damaged by __ and immune complexes | autoantibodies |
| __% of all patients with SLE are women | 90 |
| in the US the highest incidence of SLE is in | African American females |
| ultraviolet light: triggers photosensitivity, rashes, drugs: sulfonamides, cigarette smoking, infections: EBV, ?parvo B-19, hormones | environmental factors for SLE |
| systemic/constitutional clinical manifestations of SLE | fatigue, malaise |
| cardiopulmonary clinical manifestations of SLE | pleuritis/pleural effusion, pericarditis/pericardial effusions |
| neuropsychiatric clinical manifestations of SLE | cognitive impairment |
| gastrointestinal clinical manifestations of SLE | hepatitis, pancreatitis |
| dermatologic clinical manifestations of SLE | photosensitivity, malar rash, discoid lesions, alopecia |
| most serious manifestation of SLE | Renal (nephritis) |
| __% of patients with SLE develop nephrotic syndrome as well | 50 |
| in SLE, untreated nephritis can lead to ESRD in __ years | 2 |
| classical arthritis presentation of SLE | polyarthritis similar distribution to RA |
| Fixed erythema, flat or raised over the malar eminences | Malar rash |
| Raised patches with scaling, follicular plugging; scarring of older lesions | discoid rash |
| Unusual rash triggered by sunlight; by history or observation | Photosensitivity |
| Oral or nasopharyngeal; usually painless | oral ulcers with SLE |
| Non-erosive involving ≥2 or more peripheral joints; + tenderness, ± effusion | arthritis with SLE |
| Persistent proteinuria (>0.5g/d or 3+)OR cellular casts | renal disorder with SLE |
| Seizures or psychosis (no other known causes of either) | neurologic disorder with SLE |
| Hemolytic anemia OR leukopenia OR lymphopenia | hematologic disorder with SLE |
| Anti-DNA OR anti-Sm OR+ antiphospholipid antibodies | immunologic disorder with SLE |
| + ANA titer in the absence of any drug known to be associated with drug-induced lupus syndromes | antinuclear antibody |
| order first; best screening test for SLE. 98% prevalence | ANA-antinuclear antibodies |
| high titers diagnostic; may correlate with disease activity. 70% prevalence | dsDNA-double stranded DNA |
| causative drugs: many= antiarrhythmics, antihypertensives, antibiotics, anticonvulsants: hydralazine, procainamide, quinidine, isoniazid, diltiazem, minocycline | Drug-induced Lupus Erythematosus (DILE) |
| Syndrome of + ANA associated with constellation of symptoms including malaise, fever, arthritis (± myalgias), rash, serositis, autoimmune-mediated response more common in Caucasians, renal/CNS symptoms are rare | Drug-induced Lupus Erythematosus (DILE) |
| cimetidine, hydralazine, HCTZ, penicillin, sulfonamides, terbinafine (lamisil) | drugs that precipitate flares of SLE for those that already have it |
| __ occur almost universally in SLE patients | skin lesions |
| annular or papulosquamous | subacute cutaneous lupus |
| discoid lupus | chronic cutaneous lupus |
| Patients with DLE have a __% risk of developing SLE which tends to be mild | 10-15 |
| common sites for Discoid Lupus | face, neck, scalp |
| __ are mainstay treatment of life-threatening manifestations | Systemic glucocorticoids |
| __ used for cutaneous and mild-mod musculoskeletal symptoms | Anti-malarials (mostly hydroxychloroquinine) |
Created by:
bwyche
Popular Medical sets