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Epidemiology 1

Epidemiology: Derm, Hem-Onc, Renal, Neuro

Psoriasis 2.1% of US adults (4.5M); 1M psoriatic arthritis; 200K new cases/yr
Achrocordon most common in: women & obese pts
SCC prevalence 20% of all skin ca
Keratoacanthoma epi: M>F, usually patients >50 yo
Most common type of malig melanoma Superficial Spreading MM (70-80% of all melanoma)
Superficial Spreading malig melanoma: Most common in: Caucasians; usu seen on the trunk and extremities
Acral Lentiginous malig melanoma: epi Most common MM in Asian-Americans / AA (>50% of all melanoma in these pops); Least common type of MM in Caucasians; 7% of all MM; M>F
__% of SLE patients have discoid lesions 25%
Skin involvement occurs in __% of sarcoid patients 25%
Rosacea epi F>M; 30-50 yo; peak 40-50; esp Celtics
urticaria/angioedema most common when 3rd-4th decade
scleroderma epi F>M; 20-50 yrs
necrobiosis (NLD) incidence: 2% of diabetics; female > male
Erythema nodosum: epi 18-30 year olds; F>M; poss assoc w/leukemia
psoriasis epi 2.1% of US adults (4.5M); 1M psoriatic arthritis; 200K new cases/yr
pemphigus vulgaris middle aged; Jewish/mediterranean
melanoma numbers 3% of skin ca; 66% of skin ca deaths
Paget dz 1-2% adults; 5-11% of >80; elderly in NE; FH; 1-3% develop osteosarcoma
most common Male cancer prostate ca (2d M ca COD)
thalassemia alpha: SE Asian, Chinese; beta: mediterranean
Sickle cell dz 8% carry Hgb S gene (trait); 1 in 400 births have SCD; onset in 1st yr (Hgb F falls); 40-50 yr life exp
most prevalent leukemia = CLL: 2:1 M:F; inc w/age; median onset 65 yo
CML epi young & middle age (55 yo); >80% survival 6 yrs
Hodgkin dz epi 2 peaks: 15-45 yo (M>F) & >50 yo; 7900 new cases/yr
NHL epi 20-40 yo; HIV/immunodef or exp to pesticides/solvents; 50K cases/yr
G6PD def prevalence >200M worldwide (usu AA men); X linked recessive; females rare
Most common hereditary hyper-coagulable state; mainly ltd to ? Factor V Leiden; pts of Euro extraction
Myelofibrosis peak incidence & survival 50-70 yrs old; median survival is 2-5 yr from onset; occurs in 10 to 30% of pts w/P. vera
Factor IX def prevalence AKA hemophilia B (Xmas dz); 1:30,000 live births; primarily in males
Factor VIII def prevalence AKA hemophilia A; 1:5,000 live births; primarily in males
P. vera: incidence/prevalence 60-70 yrs (mean dx age 65 yo; rare <40); M:F 1.2:1
esoph ca epidemiology Squamous cell AA>W (EtOH / tobacco); adenocarcinoma W>AA (Barrett esoph)
colorectal ca prevalence 60,000 d/yr; 3d leading COD
bladder ca 98% are TCC; 3% of ca deaths in US; 3:1 M:F; 40-70 yo
most common renal malig: RCC (renal cell ca): 3% of all adult cancers; usu AA, M, >55 yo
most common peds solid tumor: Wilms tumor
most common malig in young men: testicular ca
CKD: 5 yr survival rate = 35%
glomerulonephritis 60% kids (2-12 yo)
most common nephritic syndrome IgA nepropathy; uncommon in AA, common in Asians; Cirrhosis, Celiac Disease, HIV, CMV
ADPKD most common PKD type (> ARPKD => neonatal M&M, short life exp); usu bilateral; sxs in 4th decade
MS epidemiology F>M; 350K in US (1M world); onset 20-40 yo; most present w/relapsing form; prevalence increases with distance from equator
Glioblastoma multiforme (GBM) epi 50% of Astros; >60 yo; rare <30; 1 yr survival
Primary CNS lymphomas: incidence increased in: Immunodef pts; AIDS; Organ TP; older pt
Bell palsy 60% R sided; more often in PG, DM; assoc w/trauma, infxn, neoplasia, toxins
Parkinson dz: epi 500,000 in US; 58 yo ave onset
myasthenia gravis younger women & older men
half of trauma related deaths in young people are: head injuries
Spinal cord injury overall incidence 4/100,000 per year
kidney stones M:F 3:1 M:!
ARPKD prevalence 1 in 20,000 live births. Often diagnosed in neonatal period
Prostate cancer Most common ca in men (no 2 cause of ca death in men). 160,000 cases/yr. AA>white.
Osteoscarcoma Most common primary malignant bone tumor (20-30% of all). 70% are metastatic or hematologic origin. 3:2 M:F. Mostly adolescents. 2nd peak in 50-60 yo if hx of XRT
Anatomic incidence of osteosarcoma 90% in metaphyseal region of long bones (50% of these around knee).
Alzheimer 60-70% of dementias. 5.3M people in US (to 14M by 2040).
Created by: Abarnard
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