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Epidemiology 3

Epidemiology: Rheum, Arthritides, Endocrine

Sarcoid prevalence Swedes, Danes, AA; F>M
Sarcoid lifetime risk 0.85% (W); 2.4% (AA)
Sarcoid mortality d/t resp fail = 1-5%
SLE epi US: 15-50/100k (MC AAF); 3x in 40 yrs; 90% F; M = less photosensitivity, more serositis; Elderly: milder dz; 65% 16-55 yo; urban > rural
Most common connective tissue disorder involving the esophagus: Scleroderma esophagus (atrophy & fibrosis of esophageal smooth mx)
Polymyositis/Dermatomyositis epi 2 peaks (kids; >50 yo); very rare; often assoc w/malig (esp DM) & other autoimm dz; PM 3:1 F:M
Inclusion Body Myositis (IBM): Epi In pts >50yrs: most common inflam myopathy; M 2X F
Scleroderma Epi F 3-4 x M; US: 10-20/ million; age, gender & ethnic sig factors in suscept; more common in AA pts; usu 3d / 4th decade
Giant cell arteritis Epi White; >50 yo; F:M = 2:1
polyarteritis nodosa 3:1 M:F, onset usu 40-60 yo; 30% assoc w/hep B
Diabetes Mellitus: incidence of acute life threatening complications DKA ( 4.6-8 episodes per 1000 pts w/ DM); hyperglycemic hyperosmolar syndrome (HHS: < 1% of all primary DM admissions)
Gout epi M 40-50 yo; F 65 yo; genetic, environmental
Prevalence inflammatory arthritis in IBD pts 30-35%
Spondylo prevalence 2:1000; usu adolescence or early adulthood
OA prevalence: 60-90% of >65; 1 in 5 adults; onset 40-60 yo; 3:1 F:M; knee OA most common cause LT disability in US
Inf arthritis incidence 2-5/100,000 (bimodal: kids, >50 yo) (in RA: 28-38/100,000)
Gono arthritis: incidence 2/3 of infxs arth in pts <40; DGI sequela; F>M (higher risk w/ menses & PG)
RA epi Worldwide: 0.8% adult; 3:1 F:M; peak onset 25-55 yo; 3-5 yr reduction in life exp; Incidence is declining
Osteoporosis F>M (4:1); 1.7M fx in US; 6M hip fx world; W&Asian > Hisp > AA; 4 in 10 WF will fx
Androgen-secreting adrenal ca prevalence More common than adenomas
most common thyroid neoplasm papillary (75-80%); 3:1 F:M, inc w/age; other: follicular, medullary, anaplastic
Hypothyroid prevalence 2% of US F (0.2% US M); 1 in 4000 newborns
Graves dz 6:1 F:M. 20-40 yo. +FH. comorbid w/other autoimmune dz or Addison, celiac, cardiomyopathy
Most common cause of hyperthyroidism in US = Graves dz
Most common thyroid disorder in US = Hashimoto (chronic) thyroiditis: 1% (5% of >65yo); FH, 6:1 F:M, hep C
medullary thyroid ca 1/3 sporadic, 1/3 familial, 1//3 MEN2
Most common Diabetes Mellitus complication neuropathy
Pheochromocytoma 90% benign, 10% malignant. Found in 0.1-0.5% of HTN pts. May be part of MEN syndromes
What % of Diabetes Mellitus pts have T2DM? 90% (of those, 75-80% associated with obesity)
Created by: Abarnard