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Ocular Pharma # 13

Side Effects & Supplements

What are the main ocular side effects of Prednisolone? Cataracts, Glaucoma, Activate latent viruses
What are the main ocular side effects of Chloroquine drugs? “Bulls Eye” maculopathy
What are the main ocular side effects of Amiodarone? Corneal Verticillata – corneal deposits
What are the main ocular side effects of Accutane? Dry eyes, corneal opacities, night blindness, conjunctivitis
What are the main ocular side effects of Amiodarone? Corneal Verticillata – deposits in the cornea.
What is the most important test to be performed on chloroquine drug patients? SD-­‐OCT. Other tests are Amsler gird and color vision
Are the retinal changes reversible with chloroquine drugs? No
Corneal Verticillata is seen as a side effect of what drugs? Is it reversible? Chloroquine and Amiodarone, some anti-­‐depressants, and Indocin (NSAID). Yes.
What is the most common ocular finding in Systemic lupus and the rheumatoid diseases? Dry eyes
What drug is associated with intraoperative floppy iris syndrome? Tamsulosin (Flomax)
What is the ocular side effects of sildenafil? Blue vision
What are the systemic side effects of Sympathomimetics? Warm face, red face, dry mouth, blurred vision, dizziness, loss of coordination, Increased irregular pulse rate and BP, shallow breathing
What are the systemic side effects of Parasympatholytics? Essentially the same as Sypathomimetics
What are the systemic side effects of Cholingergic agonists (parasympathomimetics)? Sweating, slower heart and lower BP, increased salivation, dizzy & headache, muscle weakness, weak breathing
What are the most common ocular side effects of the antiviral agents topically? Corneal toxicity
What are the systemic side effects of topical beta blockers? Decreased heart rate, lower BP, and difficulty breathing
What is the difference between anaphylaxis and idiosyncratic reactions? Anaphylaxis is a potentially deadly hypersensitivity reaction from any antigen. History of hives, hay fever, asthma. Idiosyncratic reaction totally unexpected reaction (no past history). It is rare and unpredictable.
What are the symptoms of anaphylactic reaction? Sx. of anaphylaxis are onset within 20-­‐30 minutes, difficulty breathing, rapid weak pulse, and deep burning pain, there may be swelling of the face and throat.
What is the ARED’S study? Age related Eye Disease study – determines what antioxidants, vitamins, etc., are necessary to slow the progression of ARMD.
For what disorder and stage does it recommend vitamins/antioxidants? Mainly for the moderately advanced ARMD cases.
What are the main ingredients in the ARED’S formula? Lutein, zeaxanthine, beta carotene, zinc and copper, Vit A, C, and E
What is the importance of copper in the ARED’S? Zinc can interfere with iron adsorption. Copper offsets this
What is the importance of Omega-­‐3 supplements for ARMD, dry eye? It has been found very helpful in both ARMD and Dry eye problems
What is a side effect of Omega 3? Can cause bleeding
What are the main systemic complications from carbonic anhydrous inhibitors? Renal stones, tingling of the extremities, GI upset, cross allergy to sulfa, depression, decreased libido
Can you name some antimetabolite (Immunomodulators) drugs? Methotrexate, Cyclosporine, cyclosporine,
What can be seen in SE or Rheumatoid disorders? Dry eye, Scleritis, Episcleritis, Uveitis, Corneal thinning.
What supplements can have ocular or systemic side effects? Calcium, Vitamin A, Omega 3, Ginkgo Biloba, Zinc, Vitamin E
Created by: Leequa