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Ocular Pharma # 13
Side Effects & Supplements
Question | Answer |
---|---|
What are the main ocular side effects of Prednisolone? | Cataracts, Glaucoma, Activate latent viruses |
What are the main ocular side effects of Chloroquine drugs? | “Bulls Eye” maculopathy |
What are the main ocular side effects of Amiodarone? | Corneal Verticillata – corneal deposits |
What are the main ocular side effects of Accutane? | Dry eyes, corneal opacities, night blindness, conjunctivitis |
What are the main ocular side effects of Amiodarone? | Corneal Verticillata – deposits in the cornea. |
What is the most important test to be performed on chloroquine drug patients? | SD-‐OCT. Other tests are Amsler gird and color vision |
Are the retinal changes reversible with chloroquine drugs? | No |
Corneal Verticillata is seen as a side effect of what drugs? Is it reversible? | Chloroquine and Amiodarone, some anti-‐depressants, and Indocin (NSAID). Yes. |
What is the most common ocular finding in Systemic lupus and the rheumatoid diseases? | Dry eyes |
What drug is associated with intraoperative floppy iris syndrome? | Tamsulosin (Flomax) |
What is the ocular side effects of sildenafil? | Blue vision |
What are the systemic side effects of Sympathomimetics? | Warm face, red face, dry mouth, blurred vision, dizziness, loss of coordination, Increased irregular pulse rate and BP, shallow breathing |
What are the systemic side effects of Parasympatholytics? | Essentially the same as Sypathomimetics |
What are the systemic side effects of Cholingergic agonists (parasympathomimetics)? | Sweating, slower heart and lower BP, increased salivation, dizzy & headache, muscle weakness, weak breathing |
What are the most common ocular side effects of the antiviral agents topically? | Corneal toxicity |
What are the systemic side effects of topical beta blockers? | Decreased heart rate, lower BP, and difficulty breathing |
What is the difference between anaphylaxis and idiosyncratic reactions? | Anaphylaxis is a potentially deadly hypersensitivity reaction from any antigen. History of hives, hay fever, asthma. Idiosyncratic reaction totally unexpected reaction (no past history). It is rare and unpredictable. |
What are the symptoms of anaphylactic reaction? | Sx. of anaphylaxis are onset within 20-‐30 minutes, difficulty breathing, rapid weak pulse, and deep burning pain, there may be swelling of the face and throat. |
What is the ARED’S study? | Age related Eye Disease study – determines what antioxidants, vitamins, etc., are necessary to slow the progression of ARMD. |
For what disorder and stage does it recommend vitamins/antioxidants? | Mainly for the moderately advanced ARMD cases. |
What are the main ingredients in the ARED’S formula? | Lutein, zeaxanthine, beta carotene, zinc and copper, Vit A, C, and E |
What is the importance of copper in the ARED’S? | Zinc can interfere with iron adsorption. Copper offsets this |
What is the importance of Omega-‐3 supplements for ARMD, dry eye? | It has been found very helpful in both ARMD and Dry eye problems |
What is a side effect of Omega 3? | Can cause bleeding |
What are the main systemic complications from carbonic anhydrous inhibitors? | Renal stones, tingling of the extremities, GI upset, cross allergy to sulfa, depression, decreased libido |
Can you name some antimetabolite (Immunomodulators) drugs? | Methotrexate, Cyclosporine, cyclosporine, |
What can be seen in SE or Rheumatoid disorders? | Dry eye, Scleritis, Episcleritis, Uveitis, Corneal thinning. |
What supplements can have ocular or systemic side effects? | Calcium, Vitamin A, Omega 3, Ginkgo Biloba, Zinc, Vitamin E |