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BBC pharm
ch. 35: antihyperglycemic and hypoglycemic meds
| Question | Answer |
|---|---|
| first line med fore type II diabetes? | metformin. if unsuccessful, dose can be increased, or other drugs can be added. |
| criteria for diagnosis of DM? | faster serum greater than 126 OR random glucose >200 with symptoms OR a serum glucose of >200 2 hrs after 75g glucose given (OGGT) OR HbA1c>6.5%. any pos test must be confirmed with another test. |
| those that are approaching diabetes type 2 but still do not have the criteria for that diagnosis are said to have.. | metabolic syndrome (pre-diabetes). fasting serum glucose in these people are 100-125 mg/dL |
| regular monitor for diabetes sugars after diagnosis should be done how often and with what test? | every six months with HbA1c, which should always be maintained below seven percent. |
| metformin goes under what category of drugs? | biguanide. |
| MOA of biguanide? | inhibit absorption of glucose from gut, decrease glucose output y liver, increase glucose uptake in adipose tissue and sk. muscle. |
| metformin sholuld be stopped when/ | prior to administration of IV contrast agents and should not be re started for 48 hours thereafter. |
| metformin should be avoide din those who... | abuse alcohol, severe CHF, or liver or renal failure. |
| class of a carbose? | alpha glucosidase inhibitor. inihibts the GI tracts ability to degrade carbohydrates, making glucose less available for absoprtion. |
| another alpha glucosidase inhibitor? | miglitol, has same MOA and effects as acarbose |
| MOA of thiazolidinediones? | sensitize skeletal muscle and fat tissue to isulin. |
| MOA of glitazones? | potential to cause edema, weight gain, new onset HF, and exacerbation of pre existing CHF. all are heaptotoxic |
| these are non sulfonylurea secretagogues. | meglitides |
| this category work to promote insulin release from beta islet cells. this MOA has a decreased effect after long term treatment with sulfonylureas. | sulfonylureas |
| this is an analogue of amylin, a rmone released by beta islet cells att eh same tie as insulin is released | pramlintide. |
| FINISH this chapter |
Created by:
aferdo01
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