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BBC Pharm
Ch 14 inhibitors of Transcription
Term | Definition |
---|---|
process of making mRNA form DNA. mRNA is translated to make protein | transcription |
this is a transcription in inhibitor and is bactericidal for intra and extra cellular mycobacterium. it is used in a wide range of mycobacterial infections, including leprosy, TB, and atypical mycobacterial infections. also used for contact meningitis. | rifampin |
rifampin is contraindicated in what patients? | with hepatic disease because its significantly hepatotoxic. causes BMD, and mostly thrombocytopenia. |
what are some ABX related to rifampin with similar MOA and side effects? | rifapentine and rifabutin. |
which drug affects prokaryotes? | rifampin |
which drugs affect eukaryotes? | alpha amanitin, actinomycin D, doxorubicin |
this is the toxin in many poison mushrooms, causes inhibition of mRNA production in eurkaryotes. | alpha amanitin |
this is an antibiotic cytotoxin which is an inhibitor of DNA replication, is also a transcription inhibitor. causes BMD. indicated in cancer of breast and lung, ALL, lymphoma. | actinomycin D |
antibiotic cytotoxin which is an inhibitor of DNA replication, also a transcription inhibitor. has same ADRs as actinomycin plus it causes red urine and dilated cardiomyopathy. | doxorubicin |