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BBC Pharm

Ch 14 inhibitors of Transcription

process of making mRNA form DNA. mRNA is translated to make protein transcription
this is a transcription in inhibitor and is bactericidal for intra and extra cellular mycobacterium. it is used in a wide range of mycobacterial infections, including leprosy, TB, and atypical mycobacterial infections. also used for contact meningitis. rifampin
rifampin is contraindicated in what patients? with hepatic disease because its significantly hepatotoxic. causes BMD, and mostly thrombocytopenia.
what are some ABX related to rifampin with similar MOA and side effects? rifapentine and rifabutin.
which drug affects prokaryotes? rifampin
which drugs affect eukaryotes? alpha amanitin, actinomycin D, doxorubicin
this is the toxin in many poison mushrooms, causes inhibition of mRNA production in eurkaryotes. alpha amanitin
this is an antibiotic cytotoxin which is an inhibitor of DNA replication, is also a transcription inhibitor. causes BMD. indicated in cancer of breast and lung, ALL, lymphoma. actinomycin D
antibiotic cytotoxin which is an inhibitor of DNA replication, also a transcription inhibitor. has same ADRs as actinomycin plus it causes red urine and dilated cardiomyopathy. doxorubicin
Created by: aferdo01