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DMARDs

AgentSite of Action
Enbrel (etanercept) Anti-TNF (parenteral)
Remiade (infliximab) Anti-TNF (parenteral)
Humira (adalimumab) Anti-TNF (parenteral)
Cimzia (certolizumab) Anti-TNF (parenteral)
Simponi/ Simponi Aria (golimumab) Anti-TNF (parenteral)
Kineret (anakinra) Recombinant interleukin-1 antagonist (parenteral)
Orencia (abatacept) Anti-CD80/CD86 --> blocks interaction with CD28 --> down-regulation of T-cell (parenteral)
Rituxan (rituximab) Anti-CD20 --> B-cell depletion (parenteral)
Actemra (tocilizumab) Interleukin-6 receptor inhibitor --> reduction in cytokine and acute phase reactant production (parenteral)
Xeljanz (tofacitinib) Janus Kinase (Jak) inhibitor --> decreased intacellular signal transmission (oral)
Created by: mhaas1988
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