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Spleen and Thymus
| Question | Answer |
|---|---|
| Splenomegaly ? | * dragging sensation in LUQ, can see from infections, heme issues, congestion, cirrhosis, etc. |
| Hypersplenism ? | * overactivity of the spleen in making ABs or even phagocytic activity inside the spleen that leads to splenomegaly |
| Conditions Associated with Splenomegaly ? | * Felty’s Syndrome and Gaucher’s Disease |
| Infectious Mononucleosis ? | * Fever, sore throat, lymphadenopathy and atypical lymphocytes .... * spleen is enlarged and have to watch out for rupture in athletes |
| Nonspecific Acute Splenitis ? | * Splenomegaly due to blood-borne infections.... * congestion of red pulp ..... * Effacement of lymphoid follicles..... * Neutrophils, plasma cells & eosinophils throughout red & white pulp |
| Congestive Splenomegaly ? | * from Cirrhosis or splenic outflow blockage.... * thickened fibrous capsule |
| Splenic Infarcts ? | * emboli from heart most common .... * from an occlusion of a splenic artery... * see large map like scars on the outside of the spleen |
| Hyposplenism ? | * sickle cell anemia is most common cause.... * see Howell-Jolly bodies in a PB .... * can be leathal |
| Neoplasms of Spleen ? | * if the spleen has cysts, think parasitic infection... common is echinococcal disease |
| Congenital Anomalies of the Spleen ? | * can see Asplenia, Hypoplasia, and even an Accessory Spleen |
| Thymus Overview ? | * in anterior mediastinum and play a role in cell-mediated immunity .... see whorls of medullary epithelial cells with keratinized cores |
| Thymic Development issues ? | * DiGeorges or Aplasia |
| Thymic Hyperplasia ? | * Appearance of B-cell germinal centers within thymus --- think 65-75% of cases of Myasthenia Gravis |
| Thymomas ? | * Tumors of thymic epithelial cells.... * Cortical thymomas rich in CD4+ or CD8+ thymocytes associated with Autoimmune diseases = Graves’, pernicious anemia, dermatomyositis-polymyositis, Cushings |
| Noninvasive thymomas ? | * cytologically benign with a whorl pattern |
| Invasive thymomas ? | * cytologically benign, but can mets..... * see numerous thymocyes, not whorled |
| Thymic Carcinoma ? | * cytologically malignant.... * most are Squamous cell carcinomas |
Created by:
thamrick800
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