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Toxocolgy FC

flash cards for toxocolgy exams

chlorpromazine,Thioridazine,fluphenazine?? there are antipsychotic drugs phenothiazines CPZ is least potent ThRZ is most fetalities FPhZ is most potent
MOA of phenothiazines 1-dopamine receptor blocker "basal ganglia ,limbic sys " /2-alpha adrenergic receptor blocker=> postural hypotension& tachcardia /3-anticholinergic =>mydriasis sinus tachycardia hyperthermia etc /4-histamine blocker and myocardial depressant
fatal dose of phenothiazines 15 to 150mg\kg fetal period hours in acute arrhythmia and it takes days with neuroleptic malignant syndrome
clinical picture of phenothiazines toxicity "CVS " 1-hypotention /2-sinus tachycardia /3-Av block /4-Arrhythmia most imp cause of death "ventricular fibrillation"
clinical picture of phenothiazines toxicity "CNS" - cns depression ataxia - hypothermia - acute dystonia ,parkinsonism ,Tardive dyskinesia
Neuroleptic malignant syndrome hyperpyrixia , delirium coma, lead pipe muscle rigidity, tachycardia and unstable blood pressure rhabdomyolysis with increased CPKase myoglobinuria mortality 20%
Created by: Ad-jet