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Renal System O1
Case Opening- Polyuria, Ratliff, 1/4/2013
Question | Answer |
---|---|
Multiple voids of small amount, Daily urine volume is within normal | Urinary Frequency |
Polyuria | Increased urine volume (>2.5-4 L/day or >2ml/min) |
Units of Osmolality | Osm/Kg |
Units of Osmolarity | Osm/L |
Measure of osmotic pressure gradient between two solutions | Tonicity |
Intracellular fluid volume | 25 L |
Extracellular fluid volume | 15 L |
Interstitial fluid volume | 12 L |
Plasma Volume | 3 L |
Urine Osmolality range | 50mOsm/Kg-1400mOsm/Kg |
Normal Serum Osmolality | 285-295 mOsm/Kg |
Hypernatremia does NOT occur if | Thirst is intact and there is access to free water |
Hyposmolality leads to a net | Water retention in excess of solute |
Osmolality is regulated by | Sensors, Mediators, and Thirst |
Thirst is triggered at serum Osm of | 290 mOsm/Kg |
Water permeable sites in the nephron | Proximal tubule, descending loop, Collecting ducts(with ADH) |
Water impermeable sites in the nephron | Ascending loop, DCT |
Urine Osm > Serum Osm | Osmotic diuresis |
Serum Osm > Urine Osm | Water diuresis |
If patient with water diuresis is given DDAVP and produces hypertonic urine, what is the diagnosis? | Hypothalamic diabetes insipidus aka they werent producing ADH |
An adult that does not respond to DDAVP could be diagnosed with 2 things | Lithium toxicity or Hypercalcemia |