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Path 19 Pancreas


Most common congen anom of pancreas. failure of fusion of fetal duct systems of dorsal and ventral pancreatic primordia Pancreas Divisum
band like ring of panc tissue that completely encircles the 2nd part of duodenum. gastric distention and vomit Annular Pancreas
Reversible panc parenchymal injury associated w inflamm. Biliary tract disease and alcoholism account for most cases. foci of fat necrosis and red-black hemorrhage. Hereditary: inactivating mut in SPINK1 gene->active trypsin-> autodigestion. Acute Pancreatitis - High serum amylase, then high serum lipase
inflamm of panc w irreversible destruction of endocrine parenchyma. Long Term Alcohol Abuse. PRSS1 and SPINK1 and CFTR gene muts associate. parenchymal fibrosis, reduced #/size of acini (spare islets of Langerhans), dilated panc ducts. ->DM Chronic Pancreatitis
benign cystic neoplasm of glycogen rich cuboid cells around small cyst of clear, thin, strawcolor fluid. Women >60. ab pain. Benign Serous Cystadenomas
painless, slow-growing mass, larger, filled w thick mucin, lined by columnar mucin-producing epithel w dense stroma. can be invasive. Women, body/tail of panc. mucinous cystic neoplasm
More common in Men, head of panc. lack dense "ovarian" stroma and involve large pancreatic ducts. can be malignant Intraductal Papillary Mucinous Neoplasms (IPMNs)
large, well-circumscribed mass, have solid and cystic components. activating Beta-catenin muts Solid-pseudopapillary neoplasm
Precursor lesions=panc intraepithel neoplasias (PanINs). KRAS most freq mut oncogene. p16/CDKN2A (w melanomas) most freq inactivated tumor suppressor gene, also SMAD4 and p53. Black Ashkenazi Jews b/w 60 and 80, and smoking. most in head of panc. Pancreatic Carcinoma
Created by: Jakphooey