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Renal System O1

Introduction to Renal: Fuctional Anatomy and Processes, Hamra, 128/2013

Functions of the Kidney Regulation of water/electrolyte balance, Excretion of metabolic waste, excretion of bioactive substances, regulations of arterial pressure, Regulation of red blood cell production, regulation of vit D production, Gluconeogenesis
Kidneys receive what percent of the cardiac output? 20%
ALl renal corpuscles are located in the Cortex
3 types of nephrons Superficial, mid-cortical, juxtamedullary
Three layers of the filtration barrier Capillary endothelium, Glomerular basement membrane, Layer of epithelial podocytes
The capillary endothelium allows passage of everything except Blood cells and platelets
Define filtration slits Spaces between the pedicles
What bridges the slits between pedicles Slit diaphragms
The filtration barrier is covered with glycoproteins with what type of charge? Negative
Which is more easily filtered, negative or positively charged solutes Positive because the barrier is negative and repels negative ions
The filtration barrier allows passage of large volumes of fluid but restricts filtration of Large plasma proteins like albumin
Glomerular capillary loops are supported by a network of Mesangial cells
When mesangial cells contract, what happens to the surface area of the capillary membrane? Decreases
Specialized epithelial cells of the thick ascending limb where it contacts its glomerulus Macula densa
Juxtaglomerular cells, or granular cells, are specialized smooth muscle cells that are located in The wall of the afferent arteriole
What is the majority of innervation in the kidney Sympathetics
Define freely filtered Substance that is present in the filtrate at the same concentration as found in the plasma (aka NOT bound to proteins)
Glomerular filtrate is mostly like plasma except it contains very little Protein
Units of GFR Volume of filtrate formed per unit time
Role of the Loop of Henle Reabsorbs 20% of filtered NaCl and 10% of water, therefor diluting the luminal fluid relative to normal plasma and the surrounding interstitium
Cortical connecting tubules and collection ducts are regulated by which two hormones Aldosterone and ADH
With aldosterone present, do you have more sodium present in the final urine or less? Less
With ADH present, is the final urine more concentrated or dilute Concentrated
What is the role of cortisol? Inhibits reabsorption of calcium
ANP causes you to do what? Dump sodium and water
Created by: mcasto