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Path 18
Inflammatory Skin Disease
| Question | Answer |
|---|---|
| The cells that make up the epidermis are known as? | keratinocytes |
| what do langerhans cells do | process antigens |
| What do Merkel cells do? | act as mechanoreceptors |
| Dermatitis is often used to refer to ? | spongiotic dermatitis (also referred to clinically as eczema) |
| What is Acne Vulgaris | a disease of the follicle in where there is occlusion by keratin and sebum resulting in the overgrowth of propionibacterium acnes |
| What are the open and closed comedones called | blackheads and whiteheads |
| What is another term for vasculitis | leukocytoclastic vasculitis |
| What is the hallmark of vasculitis | palpable purpura |
| What are the pathological findings of vasculitis | infiltration of the vessel walls by neutrophils, endothelial swelling, fragmentation of neuclei of neutrophils (leukocytoclasis), erythrocyte extravasation, and sometimes thrombotic vessel occlusion, and fibrin depositition |
| What is Erythema Multiforme | eruption of macules, papules, vesicles, or bullae with a widespread distribution pattern |
| What is the name of erythema multiforme with mucous membrane involvement | Stevens Johnson Syndrome |
| What is the name of the Erythema Multiforme in which there can be extensive exfoliation of the skin | TEN toxic epidermal necrolysis |
| What are some triggering factors of Erythema Multiforme | herpes simplex, other infectious agents, and drugs |
| What are the three main microscopic findings of EM | vacuolar degeneration of the basilar layers, formation of eosinophilis, apoptotic bodies at the dermal-epidermal junction and at all levels of the epidermis |
| What is impetigo | a superficial bacterial infection caused by S. Aureus or S. pyrogenes |
| How do patients with impetigo present? | with erythematous papules that evolve into blisters or putules. These then rupture and produce the characteristic honey colored crusts |
| What is an example of a possible complication of impetigo | poststreptococcal glomerulonephritis |
| Where are there aggregates of neutrophils with impetigo | at the epidermal surface |
| Syphilis is a sexually transmitted disease caused by ? | Treponema pallidum |
| What is the name of the primary lesion in syphilis | chancre |
| Is the primary lesion of syphilis painful or painless? | painless |
| What are the skin lesions of secondary syphilis | condyloma lata, maculopapular eruptions that typically involve the palms and soles |
| What is the characteristic nodular or ulcerative lesion of the tertiary stage of syphilis | Gumma |
| What is the inflammatory cell found commonly at all stages of syphilis | plasma cells |
| Warts, or verrucae are cutaneous tumors induced by? | types of HPV |
| What are the four main kinds of warts? | Verruca Vulgaris, Vurruca Plantaris, Verruca plana, Condyloma acuminatum |
| What is the name of keratinocytes with pyknotic nuclei surrounding clear halos that may be aggregated near the epidermal surface? | Koilocytes |
| What are flesh colored dome shaped papules or small nodules with central keratotic cores | Molluscum Contagiosum |
| The causative agent in molluscum contagiosum is a member of what virus family | poxvirus |
| What are the most common herpesvirus infections due to? | herpes simplex 1 and 2, and varicella zoster virus |
| What are the most common superficial fungal infections caused by? | Dermatophytes, Candida albicans, adn the yeast pityrosporum |
| What is the hyphal form of pityrosporum | Malassezia furfur |
| What fungus is often a factor in diaper dermatitis | Candida |
| What is the cause of tinea versicolor | Malassezia furfur |
| What pathological changes do Dermatophytes and Candida infections often show | changes of spongiotic dermatitis |
| Where is the most common location for scabies lesions | fingerwebs, wrists, trunk, genitalia |
Created by:
UVAPATH1
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