Busy. Please wait.
Log in using Clever

show password
Forgot Password?

Don't have an account?  Sign up 
Sign up using Clever

Username is available taken
show password


Make sure to remember your password. If you forget it there is no way for StudyStack to send you a reset link. You would need to create a new account.
Your email address is only used to allow you to reset your password. See our Privacy Policy and Terms of Service.

Already a StudyStack user? Log In

Reset Password
Enter the associated with your account, and we'll email you a link to reset your password.
Didn't know it?
click below
Knew it?
click below
Don't know
Remaining cards (0)
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.

  Normal Size     Small Size show me how

Path 6

Neoplasia II pg. 1-6 Templeton

Are the majority of cases of cancer familial or sporadic sporadic
what cells are affected in familial and sporadic cancers sporadic (somatic cells) familial (germline)
How do Oncogenes contribute to cancer new or increased biochemical acivity leads to altered cell phenotype
How can a tumor suppressor gene contribute to cancer loss of activity leads directly to altered cell phenotype
How many genes have to be altered to form a cancer 4-10 (estimate)
what are proto-oncogenes normal genomic constituents with required normal functions in develpment and/or homeostasis
how are proto-oncogenes activated change in genetic coding sequence will lead to new or altered biochemical activity
what happens when bcl-2 is translocated to chromosome 18 where there is a transcriptional enhancer of immunoglobulin the bcl-2 gene product inhibits the activation of the apoptosis protease cascade in the mitochondria protecting from the action of regulatory T cells during tumorigenesis
what are two mechanisms of chromosomal translocation in activation of a proto-oncogene place proto-oncogene under new regulatory elements producing wild-type gene or Splices two coding sequences together resulting in disregulation of biochemical activity of one of the subunits
If Ig enhancers are translocated to the myc gene (chrom 8) you will get inappropriate levels of the myc gene as seen in Burkitt's lymphoma. What is the most common chain to be translocated t(8;14) Ig heavy chain
bcr-able translocation is seen in? leukemia
what is the philadelphia chromosome t(9;22) seen in CML and ALL
How can the same translocation t(9;22) be seen with two different cancers the breakpoint between bcr and abl differ in CML and ALL
what does Gleevec do? inhibits bcr-able kinase activity
what is gene amplification copying of normal genes and their promoters many times
Created by: UVAPATH1



Use these flashcards to help memorize information. Look at the large card and try to recall what is on the other side. Then click the card to flip it. If you knew the answer, click the green Know box. Otherwise, click the red Don't know box.

When you've placed seven or more cards in the Don't know box, click "retry" to try those cards again.

If you've accidentally put the card in the wrong box, just click on the card to take it out of the box.

You can also use your keyboard to move the cards as follows:

If you are logged in to your account, this website will remember which cards you know and don't know so that they are in the same box the next time you log in.

When you need a break, try one of the other activities listed below the flashcards like Matching, Snowman, or Hungry Bug. Although it may feel like you're playing a game, your brain is still making more connections with the information to help you out.

To see how well you know the information, try the Quiz or Test activity.

Pass complete!

"Know" box contains:
Time elapsed:
restart all cards