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cytokines source and action

cytokinesource and action
TGF-beta T, B, Mf -> inh T's, neg. regulator, + collagen
alpha chemokines- C-X-C monos-> attracts neutrophils (IL-8)
beta chemokines- C-C T's -> attracts monocytes (RANTES, MCAF)
TNF- alpha mf -> infl, endotoxin- induced septic shock; cachectin (inh LPL); necrosis of tumor cells
TNF- beta T cells-> aka lymphotoxin; similar to TNF-a
NO mf-> induced by LPS --> vasodilation
MIF mf-> induced by LPS -> septic shock
IFN-g Th1-> potent activator of mf, NK, neutrophil phagocytosis
Created by: micro