T, B, Mf -> inh T's, neg. regulator, + collagen

alpha chemokines- C-X-C

monos-> attracts neutrophils (IL-8)

T's -> attracts monocytes (RANTES, MCAF)

mf -> infl, endotoxin- induced septic shock; cachectin (inh LPL); necrosis of tumor cells

T cells-> aka lymphotoxin; similar to TNF-a

mf-> induced by LPS --> vasodilation

mf-> induced by LPS -> septic shock

Th1-> potent activator of mf, NK, neutrophil phagocytosis

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cytokines

cytokines source and action

cytokine	source and action
TGF-beta	T, B, Mf -> inh T's, neg. regulator, + collagen
alpha chemokines- C-X-C	monos-> attracts neutrophils (IL-8)
beta chemokines- C-C	T's -> attracts monocytes (RANTES, MCAF)
TNF- alpha	mf -> infl, endotoxin- induced septic shock; cachectin (inh LPL); necrosis of tumor cells
TNF- beta	T cells-> aka lymphotoxin; similar to TNF-a
NO	mf-> induced by LPS --> vasodilation
MIF	mf-> induced by LPS -> septic shock
IFN-g	Th1-> potent activator of mf, NK, neutrophil phagocytosis