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immunopharmacology

Mabs, immunomodulators

generictradeReceptorUse
Orthoclone OKT3 – Muromonab CD3 CD3, T cells prevent acute rejection of kidney, liver and heart transplants
Centoxin – Nebacumab lipid A polysaccharide portion of Gm- endotoxin Severe sepsis that has progressed to endotoxic shock
Abciximab Reopro GP IIb/IIIa receptor (member of integrin family) pts. w/ heart disease caused by poor blood flow in arteries of heart
Palivizumab Snygas RSV prevention of serious lower respiratory infection caused by RSV
Adalimumab Humira TNF alpha (blank)
Daclizumab Zenapax alpha subunit of IL-2 receptors (activated Tcells) kidney transplantation
Basiliximab Simulect alpha subunit of IL-2 receptor impairs immune response to antigen challenge
Infliximab Remicade TNF alpha rheumatoid arthritis and crohn’s disease
Efalizumab Raptiva LFA-1 to ICAM-1 treatment of psoriasis
Rituximab Rituxan CD20 antigen B cell lymphoma (CD20+), and non-Hodgkin’s lymphoma
Trastuzumab Herceptin (HER-2) treatment of breast cancer
Alemtuzumab Campath CD52 receptor B cell chronic lymphocytic leukemia
Gemtuzumab – ozogamacin Mylotarg CD33 receptor treatment of CD33 positive acute myeloid leukemia
Ibritumomab Zevalin CD20 B cell non-Hodgkin’s lymphoma
Tositumomab Bexxar CD20 receptors non-Hodgkin’s lymphoma
Panitumumab Vectibix epidermal growth factor receptors colorectal cancer pts
Centuximab Erbitux epidermal growth factor receptors (HER1 head, neck and colorectal cancers
Bevacizumab Avastin vascular endothelial growth factor (VEGF) malignant colon or rectal cancer
Cyclosporine (blank) targets calcineurin by binding with cyclophyllin all tissue transplantations
Tacrolimus (blank) binds to calcineurin via fk506 Tissue transplantation
Rapamycin Sirolimus FKPB (FK506) tissue transplantations, cancer—causes apoptosis
Everolimus (blank) - inhibits P7056 Prevention of graft rejection
Fingolimod (FTY 720) (blank) modulator of spingosine 1-phosphate receptor (blank)
Mycophenolate Mofetil (blank) (blank) (blank)
Created by: hansliza
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