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immunopharmacology
Mabs, immunomodulators
| generic | trade | Receptor | Use |
|---|---|---|---|
| Orthoclone OKT3 – | Muromonab CD3 | CD3, T cells | prevent acute rejection of kidney, liver and heart transplants |
| Centoxin – | Nebacumab | lipid A polysaccharide portion of Gm- endotoxin | Severe sepsis that has progressed to endotoxic shock |
| Abciximab | Reopro | GP IIb/IIIa receptor (member of integrin family) | pts. w/ heart disease caused by poor blood flow in arteries of heart |
| Palivizumab | Snygas | RSV | prevention of serious lower respiratory infection caused by RSV |
| Adalimumab | Humira | TNF alpha | (blank) |
| Daclizumab | Zenapax | alpha subunit of IL-2 receptors (activated Tcells) | kidney transplantation |
| Basiliximab | Simulect | alpha subunit of IL-2 receptor | impairs immune response to antigen challenge |
| Infliximab | Remicade | TNF alpha | rheumatoid arthritis and crohn’s disease |
| Efalizumab | Raptiva | LFA-1 to ICAM-1 | treatment of psoriasis |
| Rituximab | Rituxan | CD20 antigen | B cell lymphoma (CD20+), and non-Hodgkin’s lymphoma |
| Trastuzumab | Herceptin | (HER-2) | treatment of breast cancer |
| Alemtuzumab | Campath | CD52 receptor | B cell chronic lymphocytic leukemia |
| Gemtuzumab – ozogamacin | Mylotarg | CD33 receptor | treatment of CD33 positive acute myeloid leukemia |
| Ibritumomab | Zevalin | CD20 | B cell non-Hodgkin’s lymphoma |
| Tositumomab | Bexxar | CD20 receptors | non-Hodgkin’s lymphoma |
| Panitumumab | Vectibix | epidermal growth factor receptors | colorectal cancer pts |
| Centuximab | Erbitux | epidermal growth factor receptors (HER1 | head, neck and colorectal cancers |
| Bevacizumab | Avastin | vascular endothelial growth factor (VEGF) | malignant colon or rectal cancer |
| Cyclosporine | (blank) | targets calcineurin by binding with cyclophyllin | all tissue transplantations |
| Tacrolimus | (blank) | binds to calcineurin via fk506 | Tissue transplantation |
| Rapamycin | Sirolimus | FKPB (FK506) | tissue transplantations, cancer—causes apoptosis |
| Everolimus | (blank) | - inhibits P7056 | Prevention of graft rejection |
| Fingolimod (FTY 720) | (blank) | modulator of spingosine 1-phosphate receptor | (blank) |
| Mycophenolate Mofetil | (blank) | (blank) | (blank) |
Created by:
hansliza
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