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Pharm 3 ABX


Aminoglycosides MOA Irreversiblely inhibits PRO synthesis by binding to 30S subunit--> misreads mRNA
Aminoglycosides: cidal or static? cidal
Tetracyclines MOA Bind to 30S subunit, block binding of aminoacyl tRNA to acceptor site (A) on the mRNA-ribosome complex-->AA can't be added to the growing peptide.
Tetracyclines: cidal or static? static
Spectinomycin inhibits PRO synthesis by binding to 30S subunit---> doesn't misread like AG's do)
Spectinomycin: cidal or static? static
Macrolides PRO synthesis inhibitor, reversibly binds to site on 50S subunit and inhibits translocations step where tRNA moves from A site to P site
Macrolides: static or cidal? static
Lincosamides reversibly binds to 50S, like macrolides
Lincosamides: static or cidal? static
Chloramphenicol PRO synthesis inh. REVERSIBLY binds to 50S, inh. transpeptidation by inh. peptidyl transferase. Prevents binding of AA end of aminoacyl tRNA to acceptor site on 50S subunit
Chloramphenicol: static or cidal? Static
Oxazolidione (Linezolid) inh PRO. Binds to 23S of RNA of the 50S subunit-->nonfunctional 70S initiation complex which is an essential step in the translation process
Oxazolidione: what is unique? unique MOA, doesn't show cross resistance to other abx.
Streptogramins bind to 23S RNA or 50S subunit; do not induce the methyl's enzyme (not subject to MLS resistance)
PCN same as other B-lactam abx. Distrupts synthesis of peptidoglycan layer of bacterial cell wall. inhibits final stage of cell wall synthesis (cross linking) structural analog of d-ala d-ala
cephalosporins: cidal/static cidal
PCN: cidal/static? cidal
cephalosporins disrupts synthesis of peptidoglycan layer of bacterial cell wall
carbapenems inhibition of cell wall synthesis
carbapenems: cidal or static? cidal
monobactam disrupts synthesis of peptidoglycan layer of bacterial cell wall
monobactam: cidal/static? cidal
vancomycin inhibits cell wall synthesis by irreversibly binding to the pair of d-ala molecules of cell wall precursor units
vanco: cidal/static static
bacitracin inhibits cell wall synthesis by binding to precursor of cell wall and forming unusable complex; acts 1 step before the one inhibited by vanco
fosfomycin inhibits very early stage of cell wall synthesis. inh. enolpyruvyl transferase, irreversibly blocks condensation of UDP-N-acyely glycosamine w/p-enolyruvate;
fosfomycin inhibits bacterial adherence to uroepithelial cells (enzymes needed for synthesis of peptidoglycan layer)
fosfomycin: static/cidal? cidal
sulfonamides PABA anolog, competitively inh DHPS which is required for folic acid synthesis; it only affects bacteria that synthesize their own folic acid
metronidazole nitro group is activated in anaerobic organisms to chemically reactivate intermediates that react with DNA.
metronidazole increased degradation of existing DNA, altered DNA helical structure, increased strand breaks, inhib of DNA
metronidazole cidal or static cidal
polymixins surface active agents that disrupt osmotic properties and transport mech of cell membranes in gram neg bacterial only
polymixins binds and inactivates endotoxins
mupirocin (bactroban) reversibly binds to bacterial isoleucyl-tRNA synthase and blocks PRO synthesis
fluoroquinolones inhibits DNA gyrase which is a topoisomerase responsible for breaking and rejoining DNA strands necessary for dNA replication
fluoroquinolones: cidal/static cidal
ketolides binds to 50S, same as macro lids
ketek black box warning: choninergic antagonist; careful in MG and NMBD
clindamycin can cause NMB pre and post junctional
polymyxin B and E skeletal weaknes; sig potentiation of NMB
aminoglycosides: inhibit what release of ach and decreases sensitivity at junction to ach, can potentiate NMBD and lidocaine
Created by: melrunt