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Unit 3
Blood System
| Question | Answer |
|---|---|
| Functions of the Blood System | - to transport oxgygen, carbon dioxide, nutrients, electrolytes, vitamins, hormones, and wastes throughout the body - To protect the body with circulating white blood cells, antibodies of the immune system, and clotting factors |
| All cells come from | stem cells |
| An immature RBC | Reticulocyte. Becomes mature when enters bloodstream |
| Structure of Blood System | Blood is connective tissue -45% formed element -55% liiquid/plasma |
| Formed elements are comprised of | produced in the bone marrow - erythrocytes - carry oxygen - leukocytes - provide immunity - thrombocytes - key role in hemostasis (clotting) |
| Blood plasma consists of | -90% water -10% components transported throughout the body |
| Blood | fluid that circulates throughout the heart, arteries, capillaries, and veins, transporting oxygen and nutritive materials to the tissues |
| Blood : formed elements | blood cells |
| Blood : plasma | liquid portion of blood that carries formed elements, clotting factors, minerals, and proteins |
| Blood : serum | liquid portion of blood after removal of clotting factors and blood cells |
| Bone marrow (blood forming organ) | soft tissue within bone, with multiple functions including the production of blood cells |
| Bone marrow : erythropoietin (EPO) | hormone released by kidneys that stimulates red blood cell production in bone marrow |
| Bone marrow : hematopoiesis | formation of blood cells and other formed elements |
| Spleen (blood forming organ) | vascular lymphatic organ responsible for filtering blood, destroying old red blood cells, producing red blood cells before birth , and storing blood |
| Formed element : erythrocyte | blood cell that carries oxygen and carbon dioxide |
| Erythrocyte : Hemoglobin (HGB , Hb , Hgb) | protein in red blood cells that binds to oxygen; gives red blood cells the characteristic color |
| Iron (Fe) | essential trace element necessary for hemoglobin to transport oxygen on red blood cells |
| Erythrocyte : Macrocyte | a large red blood cell |
| Erythrocyte : Rh factor | protein substance present in the red blood cells of most people (85%) that is capable of inducing intense antigenic reactions |
| Formed element : leukocyte | white blood cell , largest blood cell , protects against pathogens, foreign substances, and cell debris |
| Leukocyte : granulocyte | white blood cell with visible granules; the three types of granulocytes are named according to the type of dye each is attracted to |
| Leukocyte : agranulocyte | white blood cell without clearly visible granules |
| Different types of leukocytes | -Granulocytes : neutrophil , eosinophil , basophil -Agranulocytes : lymphocyte , monocyte |
| Formed element : thrombocyte , platelet (PLT) | cell fragments in the blood that stick together, forming a clot |
| Blood Clotting : Clotting Factors | any of the various plasma components involved in the clotting process |
| Blood Clotting : Coagulation | clotting; changing from liquid to a solid state |
| Blood Clotting : Fibrin | elastic fiber protein needed in clotting and produced by fibrinogen |
| Blood Clotting : Fibrinogen | plasma protein that is converted into solid threads called fibrin |
| chrom/o , chromat/o | color |
| cyt/o | cell |
| erythr/o | red |
| granul/o | granules |
| hem/o , hemat/o | blood |
| immun/o | immune, safe |
| leuk/o | white |
| lymph/o | lymph |
| neutr/o | neutral |
| nucle/o | nucleus |
| path/o | disease |
| phag/o | eat, swallow |
| phleb/o | vein |
| plas/o | formation , growth |
| thromb/o | blood clot |
| auto- | self, same |
| basi- , baso- | base |
| macro- | large, long |
| micro- | small |
| mono- | one |
| pro- | before, promoting |
| poly- | many, much |
| -cyte | cell |
| -emia | blood (condition of) |
| -sis | condition, process |
| -gen | origin, production |
| -lysis | destruction , breakdown , separation |
| -osis | abnormal condition |
| -penia | deficiency |
| -philia | attraction for |
| -poiesis | production , formation |
| -rrhage | flowing forth |
| -y | condition of |
| hematopoietic | pertaining to the formation of blood cells |
| hemolytic | pertaining to the rupture or destruction of red blood cells |
| hemorrhagic | pertaining to profuse or excessive bleeding |
| hemostasis | stoppage or arrest of bleeding |
| anemia | condition in which the number of red blood cells, hemoglobin, or volume of packed cells is lower than normal |
| clotting disorder | condition characterized by an inability of blood to coagulate |
| hemochromatosis | excessive absorption and storage of dietary iron in body tissues causing dysfunction |
| pancytopenia | deficiency in all types of blood cells |
| polycythemia | increase of red blood cells |
| septicemia | spread of microorganisms or toxins through circulating blood |
| aplastic anemia | disorder in which bone marrow does not produce enough red blood cells to transport oxygen due to a lack of iron |
| pernicious anemia | disorder in which the number of red blood cells declines with simultaneous enlargment of individual cells (ex. macrocytes) due to an inability to absorb vitamin B-12 |
| hemorrhagic anemia | blood loss anemia- disorder involving lack of red blood cells due to profuse blood loss |
| thalassemia | disorder caused by a genetic defect resulting in low hemoglobin production |
| sickle cell anemia | disorder caused by a genetic defect resulting in abnormal hemoglobin causing sickle-shaped red blood cells, which have difficulty moving through small capillary vessels |
| Normal platelet count | 140,000 - 400,000 |
| Increased bleeding time | <100,000 |
| Spontaneous bleeding | <10,000 |
| Hemophilia | bleeding disorder due to a deficiency of a clotting factor |
| thrombocytopenia | disorder involving low levels of platelets in blood |
| idiopathic thrombocytopenic purpura (ITP) | disorder marked by platelet destruction by macrophages resulting in bruising and bleeding from mucous membranes |
| von Willebrand disease | bleeding disorder characterized by a tendency to bleed primarily from the mucous membranes due to a deficiency of a clotting factor |
| albumin | measurement of this protein level; used to diagnose liver or kidney problems, inflammation, malnutrition, or dehydration |
| bilirubin | screen for liver disorders or anemia |
| blood smear | evaluation of the appearance and number of blood cells and the different types of white blood cells |
| complete blood count (CBC) , hemogram | automated count of all blood cells |
| CBC: erythrocyte sedimentation rate (ESR) | time measurement of red blood cells settling in a test tube over 1 hour; used to diagnose inflammation and anemia |
| CBC: hematocrit (HCT, hct) | volume of blood occupied by red blood cells; used to diagnose various disorders including anemia |
| CBC: hemoglobin (HGB, hgb, Hb) test | test for the red blood cell protein responsible for binding oxygen; used to diagnose various disorders including anemia |
| CBC: platelet count (PLT) | number of platelets present; used to diagnose bleeding disorders or bone marrow disease |
| CBC: red blood cell count | number of erythrocytes present; used to diagnose various disorders including anemia |
| CBC: white blood cell count | number of leukocytes present; used to diagnose various disorders, including infections and diseases, and for monitoring treatment |
| cross-matching | blood typing test for compatibility between donor and recipient blood |
| prothrombin time (PT) | measurement of time for blood to clot |
| WBC differential count, differential count | evaluation of the total percentage of leukocytes |
| phlebotomy, venipuncture, venotomy | incision into a vein to inject a solution or withdraw blood |
| blood transfusion (BT) | transfer of blood between compatible donor and recipient |
| apheresis | removal and replacement of a patient's own blood or donor blood after specific components have been removed |
| autologous blood | blood donated for future use by same patient; usually presurgical |
| homologous blood | blood donate from same species for use by a compatible recipient |
| blood component therapy | transfusion of specific blood components such as packed red blood cells, plasma, or platelets |
| plasmapheresis | removal and replacement of a patient's own blood after plasma has been removed and replaced with a plasma substitute |
| bone marrow aspiration (BMA) | removal of a small amount of fluid and cells from inside the bone with a needle and syringe |
| bone marrow transplant (BMT) | transfer of bone marrow from one person to another |
| rheumatology | medical specialty concerned with diagnosis and treatment of rheumatic conditions and autoimmune diseases |
| rheumatologist | a physician who specializes in rheumatology |
| allergology | medical specialty concerned with diagnosis and treatment of allergy and sensitivity |
| allergist | physician who specializes in allergology |
| hematology | medical specialty concerned with diagnosis and treatment of disorders of the blood and blood-forming organs |
| hematologist | physician who specializes in hematology |