FA10 Labs/Findings Word Scramble
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Question | Answer |
Anticentromere antibodies | Scleroderma (CREST) |
Antidesmoglein (epithelial) antibodies | Pemphigus vulgaris (blistering) |
Anti-glomerular basement membrane antibodies | Goodpasture's Syndrome (glomerulonephritis and lung hemorrhage) |
Antihistone antibodies | Drug-induced SLE |
Anti-IgG antibodies | Rheumatoid arthritis (systemic inflammation, joint pannus, boutonniere deformity) |
Antimitichondrial antibodies (AMAs) | Primary biliary cirrhosis (female, cholestasis, portal hypertension) |
Antineutrophil cytoplasmic antibodies (ANCAs) | Vasculitis (Wegener's, microscopic polyangiitis, glomerulonephritis) |
Antinuclear antibodies (ANAs: anti-Smith and anti-dsDNA) | SLE (type II hypersensitivity) |
Antiplatelet antibodies | Idiopathic thrombocytopenic purpura (ITP) (bleeding diathesis) |
Anti-topoisomerase antibodies | Diffuse systemic scleroderma |
Anti-transglutaminase/ antigliadin antibodies | Celiac disease (diarrhea, distension, weight loss) |
Azurophilic granular needles in leukemic blasts | Auer rods (AML: especially the promyelotic type) |
"Bamboo spine" on x-ray | Ankylosing spondylitis (chronic inflammatory arthritis: HLA-B27) |
Basophilic nuclear remnants in RBCs | Howell-Jolly bodies (due to splenectomy or nonfunctional spleen) |
Basophilic stippling of RBCs | Lead poisoning or sideroblastic anemia |
Bloody tap on LP | Subarachnoid hemorrhage |
"Boot-shaped" heart on x-ray | Tetralogy of Fallot, RVH |
Branching gram-positive rods with sulfur granules | Actinomyces israelii |
Bronchogenic apical lung tumor | Pancoast's tumor (can compress sympathetic ganglion and cause Horner's syndrome) |
"Brown" tumor of bone | Hemorrhage (hemosiderin) causes brown color of osteolytic cysts. Due to: 1. Hyperparathyroidism 2. Osteitis fibrosa cystica (von Recklinghausen's disease of bone) |
Cardiomegaly with apical atrophy | Chaga's disease (Trypanosoma cruzi) |
Cellular crescents in Bowman's capsule | Rapidly progressive crescentic glomerulonephritis |
"Chocolate cyst" of ovary | Endometriosis (frequently involves both ovaries) |
Circular grouping of dark tumor cells surrounding pale neurofibrils | Homer Wright rosettes (neuroblastoma, meduloblastoma, retinoblastoma) |
Colonies of mucoid Pseudonomas in lungs | Cystic fibrosis (CFTR mutation in Caucasians resulting in fat-soluble vitamin deficiency and mucous plugs) |
Degeneration of dorsal column nerves | Tabes dorsalis (tertiary syphilis) |
Depigmentation of neurons in substantia nigra | Parkinson's disease (basal ganglia disorder: rigidity, resting tremor, bradykinesia) |
Desquamated epithelial casts in sputum | Curschmann's spirals (bronchial asthma; can result in whorled mucous plugs) |
Disarrayed granulosa cells in eosinophilic fluid | Call-Exner bodies (granulosa-theca cell tumor of ovary) |
Dysplastic squamous cervical cells with nuclear enlargement and hyperchomasia | Koilocytes (HPV: predisposes to cervical cancer) |
Enlarged cells with intranuclear inclusion bodies | "Owl's-eye" appearance of CMV |
Enlarged thyroid cells with ground-glass nuclei | "Orphan Annie" eye nuclei (papillary carcinoma of the thyroid) |
Eosinophilic cytoplasmic inclusion in liver cells | Mallory bodies (alcoholic liver disease) |
Eosinophilic cytoplasmic inclusion in nerve cells | Lewy body (Parkinson's disease) |
Eosinophilic globule in liver | Councilman body (toxic or viral hepatitis, often yellow fever) |
Eosinophilic inclusion bodies in cytoplasm of hippocampal nerve cells | Rabies virus (Lyssavirus) |
Extracellular amyloid deposition in gray matter of brain | Senile plaques (Alzheimer's disease) |
Giant B cells with bilobed nuclei with prominent inclusions ("owl's eye") | Reed-Sternberg cells (Hodgkin's lymphoma) |
Glomerulus-like structure surrounding vessel in germ cells | Schiller-Duval bodies (yolk sac tumor) |
"Hair-on-end" (crew-cut) appearance on x-ray | beta-thalassemia, sickle cell anemia (extramedullary hematopoiesis) |
hCG elevated | Choriocarcinoma, hydatidiform mole (occurs with or without embryo) |
Heart nodules (inflammatory) | Aschoff bodies (rheumatic fever) |
Heterophile antibodies | Infectious mononucleosis (EBV) |
Hexagonal, double-pointed, needle-like crystals in bronchial secretions | Bronchial asthma (Charcot-Leyden crystals: eosinophilic granules) |
High level of D-dimers | DVT, pulmonary embolism, DIC |
"Honeycomb lung" on x-ray | Interstitial fibrosis |
Hypersegmented neutrophils | Megaloblastic anemia (B12, folate deficiency) |
Hypochomic, microcytic anemia | Iron deficiency anemia, lead poisoning, thalassemia (HbF sometimes present) |
Increased alpha-fetoprotein in amniotic fluid/ maternal serum | Anencephaly, spina bifida (neural tube defects) |
Increased uric acid levels | Gout, Lesch-Nyhan syndrome, myeloproliferative disorders, loop and thiazide diuretics |
Intranuclear eosinophilic droplet-like bodies | Cowdry type A bodies (HSV or yellow fever) |
Iron-containing nodules in alveolar septum | Ferruginous bodies (asbestosis: increased chance of mesothelioma) |
Large lysosomal vesicles in phagocytes, immunocompromised | Chediak-Higashi disease (failure of phagolysosome formation) |
Low serum ceruloplasmin | Wilson's disease (hepatolenticular degeneration) |
"Lumpy-bumpy" appearance of glomeruli on immunofluorescence | Poststreptococcal glomerulonephritis |
Lytic ("hole-punched") bone lesions on x-ray | Multiple myeloma |
Mammary gland ("blue-domed") cyst | Fibrocystic change of the breast |
Monoclonal antibody spike | 1. Multiple myeloma (called the M protein; usally IgG or IgA) 2. Monoclonal gammopathy of undetermined significance (MGUS) 3. Waldenstrom's (M protein = IgM) macroglobulinemia |
Monoclonal globulin protein in blood/urine | Bence Jones proteins (multiple myeloma [kappa or lambda Ig light chains in urine]), Waldenstrom's (IgM) |
Mucin-filled cell with peripheral nucleus | Signet cell (gastric carcinoma) |
Narrowing of bowel lumen on barium radiograph | "String sign" (Crohn's disease) |
Needle-shaped, negatively birefringent crystals | Gout (hyperuricemia) |
Nodular hyaline deposits in glomeruli | Kimmelstiel-Wilson nodules (diabetic nephropathy) |
"Nutmeg" appearance of liver | Chronic passive congestion of liver due to right heart failure |
"Onion-skin" periosteal reaction | Ewing's sarcoma (malignant round-cell tumor) |
Periosteum raised from bone, creating triangular area | Codman's triangle on x-ray (osteosarcoma, Ewing's sarcoma, pyogenic osteomyelitis) |
Podocyte fusion on EM | Minimal change disease (child with nephrotic syndrome) |
Polished, "ivory-like" appearance of bone at cartilage erosion | Eburnation (osteoarthritis resulting in body sclerosis) |
Protein aggregates in neurons from hyperphosphorylation of protein tau | Neurofibrillary tangles (Alzheimer's disease and CJD) |
Pseudopalisade tumor cell arrangement | Glioblastoma multiforme |
RBC casts in urine | Acute glomerulonephritis |
Rectangular, crystal-like inclusions in Leydig cells | Reinke crystals (Leydig cell tumor) |
Renal epithelial casts in urine | Acute toxic/ viral nephrosis |
Rhomboid crystals, positively birefringent | Pseudogout (calcium pyrophosphate dihydrate) |
Rib notching | Coarctation of the aorta |
Sheets of medium-sized lymphoid cells ("starry sky" appearance on histology) | Burkitt's lymphoma (t[8:14] c-myc activation, associated with EBV) |
Silver-staining spherical aggregation of tau proteins in neurons | Pick bodies (Pick's disease: progressive dementia, similar to Alzheimer's) |
Small granulomatous lesions in lungs (can calcify) | Ghon focus (primary TB: Mycobacterium bacilli) |
Small, round RBC inclusions | Heinz bodies (G6PD deficiency, alpha-thalassemia, chronic liver disease) |
"Soap bubble" on x-ray | Giant cell tumor of bone (generally benign) |
"Spikes" on basement membrane, "dome-like" endothelial deposits | Membranous Glomerulonephritis (may progress to nephrotic syndrome) |
Stacks of red blood cells | Rouleaux formation (high ESR: multiple myeloma) |
Stippled vaginal epithelial cells | "Clue cells" (Gardnerella vaginalis) |
"Tennis-racket"-shaped cytoplasmic organelles (EM) in Langerhans cells | Birbeck granules (histiocytosis X: eosinophilic granuloma) |
Thrombi made of white/ red layers | Lines of Zahn (arterial thrombus, layers of platelets/RBCs) |
"Thumb sign" on lateral x-ray | Epiglottitis (Haemophilus influenzae) |
Thyroid-like appearance of kidney | Chronic bacterial pyelonephritis |
"Tram-track" appearance on LM | Membranoproliferative glomerulonephritis |
Triglyceride accumulation in liver cell vacuoles | Fatty liver disease (alcoholic or metabolic syndrome) |
WBCs that looked "smudged" | CLL (almost always B cells; affects the elderly) |
"Wire loop" glomerular appearance on LM | Lupus nephropathy |
Yellow CSF | Xanthochromia (subarachnoid hemorrhage) |
Created by:
megankirch
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