Antiviral HIV Pharm Word Scramble
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Question | Answer |
Life cycle of HIV ? | * binds to CD4+ or CCR5 --> into membrane --> reverse transcrition to make DS DNA --> put RNA in to be into cells |
Antiretroviral drug classes ? | * Nucleoside analogs (NRTIs or nukes) ----Nonnucleoside reverse transcriptase inhibitors (NNRTIs or non-nukes) ----Protease inhibitors (PIs) ----Integrase inhibitors ----Fusion inhibitors ----Entry inhibitors – CCR5 antagonists |
Usu initial combo ? | * 2 nukes + 1 PI or II or NNRTI |
Nucleoside analogs ? | * Lamivudine ---Zidovudine (AZT) ---Stavudine ---Didanosine |
Protease Inhibitors (PIs) ? | * Ritonavir (RTV) ---Indinavir ---Fosamprenavir ---Nelfinavir ---Saquinavir |
Nonnucleoside RT Inhibitors (NNRTIs) ? | * Efavirenz* ----Nevirapine |
Fusion inhibitor ? | * Enfuvirtide |
Entry Inhibitor – CCR5 antagonist ? | * Maraviroc |
Integrase inhibitor ? | * Raltegravir |
Nucleoside analog MOA ? | * incorporates itself as a triphosphate in to the viral DNA to stop viral replication |
Nucleoside analogs Side Effects ? | * minimal drug/drug interactions..... * Black Box Warning --> Lactic acidosis with hepatic steatosis ...... * Zidovudine - bone marrow depression = anemia |
Preferred in pregnant pts ? | * Zidovudine |
Nonnucleoside Reverse transcriptase Inhibitors(NNRTIs) MOA ? | * Same target….but binds to unique site that causes a confirmational change in enzyme so it doesn't work ..... * Bind directly to HIV-RT and are direct acting |
NNRTIs – Advantages ? | * Efavirenz - 1 pill a day..... * Nevirapine - safe in pregnancy |
NNRTIs – Disadvantages ? | * Efavirenz - neuropsych effects, teratogenic,use p450, tons of drud/drug interactions ..... * Nevirapine - hypersensitivity rash and hepatitis |
Protease inhibitors MOA ? | * Competitive inhibition of viral protease, Preventing immature virions from becoming mature |
Addition of ritonavir to Lopinavir ? | * makes Lopinavir a multiple dose a day drug to a one day dosed.... RTV is often used with other PIs to boost them |
PI Drug Interactions ? | * Eliminated by hepatic metabolism (CYP3A4) so watch in using other drugs that inhibit or induce it |
Toxicity of PIs ? | * GI issues , hepatotoxicity , lipodystroophy (moves fat to other places) , hyperlipidemia , and insulin resistance |
Integrase inhibitor MOA ? | * Blocks HIV integrase from inserting viral genome into host cell DNA..... *given injection SubQ |
Fusion inhibitor MOA ? | * Blocks the entry of HIV-1 into CD4+ cells. ---Binds gp41 subunit HIV envelope glycoprotein |
Fusion inhibitor Side Effects ? | * * Also see little wasp sting reactions where it is injected |
Entry inhibitor MOA ? | * Binds CCR5 and blocks the HIV gp120 from associating with the receptor. HIV is then unable to bind and enter cells .... * need to do receptor tests bc if HIV binds to other ones, this drug won't work, only on CCR5...... |
Created by:
thamrick800
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