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BIO201 - Ch 5 - Integumentary System - Marieb/Hoehn - Rio Salado

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Answer
Skin is composed of 2 regions.   Epidermis & dermis.  
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The __ is composed of epithelial cells & is outermost shield of body.   Epidermis.  
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The __ makes up the bulk of skin.   Dermis.  
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The dermis is made up of __.   Fibrous connective tissue.  
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Vascularized layer of skin.   Dermis layer  
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How do nutrients reach the epidermis?   Diffusing through tissue fluid from blood vessels in dermis.  
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Subcutaneous tissue just deep to skin.   Hypodermis layer.  
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Is not really part of skin but shares in protective functions.   Hypodermis  
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Another name for the hypodermis is __.   Superficial fascia  
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The superficial fascia (hypodermis) is __.   Superficial to connective tissue wrapping (fascia) of skeletal muscles.  
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They hypodermis layer contains __ tissue.   Adipose tissue.  
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The role of the hypodermis is?   Anchors skin to muscles, but is loose enough to slide.  
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The fatty composition of the hypodermis acts as __ & __.   Shock absorber & insulator.  
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Which layer thickens when we gain weight?   Hypodermis because of adipose tissue there.  
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The epidermis layer is made of __.   Keratinized stratified squamous epithelium.  
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The epidermis has __ cell types and __ to __ distinct layers.   4 cell types & 4-5 layers.  
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Most epidermal cells are __.   Keratinocytes.  
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Keratin   Helps give epidermis its protective properties.  
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Keratinocytes   Produce keratin & are tightly connected.  
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4 Types of cells in epidermis are __.   Keratinocytes, melanocytes, Merkel, & Langerhans' Cells.  
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Keratinocytes arise in the deepest epidermis called __.   Stratum basale.  
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Keratinocytes undergo almost continuous __.   Mitosis  
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We have a new epideris every __ days.   25-45 days.  
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Melanocytes   Spider-shaped epithelial cells - make melanin.  
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Melanocytes are found __.   In deepest layer of epidermis.  
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Melanin accumulates in __.   Melanosomes.  
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Melanosomes   Membrane-bound granules that store melanin.  
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Melanin is taken up by __.   Keratinocytes  
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Langerhans' cells   Star-shaped phagocytes - help in immune sys - form network.  
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Merkel cells   Associated w/merkel disk & nerve endings.  
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Merkel disk   Sensory receptor for touch.  
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Langerhans' cells - aka __.   Epidermal dendric cells.  
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Thick skin has __ layers.   5  
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Which layer is absent in "thin" skin?   Stratum Lucidum  
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Name the 5 skin layers acronym.   "Children Love Grammy's Special Brownies!"  
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Skin layers from top to bottom are __?   Corneum, Lucidum, Granulosum, Spinosum, Basale.  
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Which skin layer is known as the "horny layer"?   Stratum Corneum  
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Stratum Corneum   3/4 of epidermal thickness - Keratin - Glycolipids waterproof the layer.  
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Which skin layer is waterproofed by glycolipids?   Stratum Corneum.  
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Stratum Lucidum   "Clear Layer" - flat dead keratinocytes - parallel arrays of keratin filaments.  
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Which layer of epidermis is called the "clear layer"?   Stratum Lucidum because of the the clear, flat, dead, keratinocytes.  
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What granules are found in the Granulosum layer?   Keratohyaline & lamellated granules.  
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Above which layer are cells unable to receive nutrition?   Stratum Granulosum  
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Where will you find clear dead keratinocytes?   In the Stratum Lucidum.  
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Stratum Spinosum   "Prickly Layer" - web-like intermediate filaments abundant in this level.  
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Langerhans' cells are abundant in the __ layer.   The Stratum Spinosum.  
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Stratum Basale   "Basal layers" - Deepest - attached to dermis - "stratum germinativum.  
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Which epidermal layer has rapid division of keratinocytes?   Stratum Basale/Stratum germinativum.  
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Keratohyaline Granules   Help form keratin in upper layers.  
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Lamellated Granules   "Plated" - contain waterproofing glycolipid.  
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Above which layer are epidermal cells not nurished?   Granulosum Layer  
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Which cells are joined by desmosomes?   Keratinocytes  
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Which layer has miotic stem cells?   Basale Layer  
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Which skin region is called our "hide"?   Dermis.  
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Dermis Layer   Lower skin region - flexible connective tissue - innervated & vascularized.  
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Name the two dermis layers.   Papillary (superficial) & reticular (deeper) layer.  
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Papillary Layer   Thin areolar conn. tissue - "peglike" projections.  
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Papill   "Nipple".  
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Dermal Papillae contain __.   Capillary loops, nerve endings, & messner's corpuscles.  
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Dermal Ridges   Mounds of dermal tissue on which papillae lie.  
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Epidermal Ridges   Lie atop dermal ridges & enhance gripping ability.  
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Where do you find epidermal ridges?   Fingers & feet.  
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Fingerprints are caused by?   Films of sweat secreted along epidermal ridges.  
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Reticular Layer   80% of dermis - deep - dense irregular conn. tiss. - Nurished by cutaneous plexus.  
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Cleavage/Tension Lines   Less dense regions in dermis - lines that run longitudinally in skin.  
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Flexure Lines   Dermal folds near or at joints.  
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Striae   Stretch marks - "Streaks"  
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3 Pigments that give skin its color are?   Melanin, carotene, & hemoglobin.  
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Melanin   Polymer of tyrosine amino acids.  
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Ultraviolet radiation destroys __ stores.   Folate - needed for DNA synthesis.  
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Carotene   Yellow/orange pigment - accumulates in corneum.  
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Cyanosis   Turning blue from lack of oxygen.  
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Erythema indicates?   "Turning red" - fever, hypertension, inflammation or allergy.  
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Pallor/blanching indicates?   Fear, anemia, low blood pressure.  
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Bronzing indicates?   Hypofunction of adrenal cortex.  
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Hematomoas   Clotted blood masses.  
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What must form before a skin appendage can grow?   Epithelial bud  
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What stimulates epithelial bud growth?   Reduced production of cadherin - breaks cell connections.  
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Sudoriferous Gland   Sweat gland - 3 million.  
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2 kinds of sweat glands are?   Eccrine & apocrine  
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Eccrine Sweat Glands   "Merocrine" - Simple, coiled, tubular gland - opens to a pore.  
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Sweat is?   Hypotonic filtrate of blood released by exocytosis. 99% h2O.  
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Dermicidin   Microbe-killing peptide in sweat.  
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pH of sweat?   Acidic - 4-5  
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Sweating is regulated by?   Sympathetic Nervous System  
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Apocrine Sweat Glands   Misnomer - actually secretes by exocytosis - In axillary & genital - body odor.  
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What glands cause body odor?   Apocrine Sweat Glands  
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Ceruminous Glands   Earwax - Cerumen secretions.  
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Sebuceous Gland   Oil gland - simple, branched, alveolar, holcrine.  
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The secretion of sebum is stimulated by __.   Sex Hormones - androgens  
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Seborrhea   "Cradel Cap"  
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Pili   Hair - hard keratin - keratinized  
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Red hair is colored by __.   Iron-containing pigment trichosiderin.  
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Arrector Pili   Smooth muscle cells around hair follicle - makes goose bumps  
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2 types of hair are?   Vellus & terminal hair  
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Vellus Hair   Fine - body hair  
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Terminal Hair   Coarser, longer hair - pubic, axillary - response to sex hormones.  
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Alopecia   Baldness  
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Hirsutism   Excessive hormones  
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Nail Matrix   Responsible for nail growth.  
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Skin's 3 types of barriers.   Chemical, physical & melanin  
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Acid mantle   Low pH of skin that retards bacterial multiplication.  
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Human defensin   Natural antibiotics secreted by skin - punches holes in bacteria.  
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Cathelicidins   Protective peptide secreted by wounded skin - good against Strep-A  
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Physical/Mechanical Barriers   Provided by continuity of skin, harness of keratinized cells, & glycolipids.  
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Biological Barriers   Langerhans' cells in epidermis, macrophages in dermis, & DNA.  
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How does DNA protect the body?   Electrons in DNA absorb UV radiation & turn it into heat.  
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Basal Cell Carcinoma   Most common skin cancer - 99% curable w/surgery.  
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Cutaneous Sensory Receptors   Exteroceptors - Meissner's corpuscle, Merkel discs, & Pacinian.  
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Metaboloic Functions of Skin   Synthesizes Vit. D, disarm cancer chemicals, activate steroid hormones.  
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Fas   Protein that causes cell suicide.  
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"ABCD" for Melanoma Recognition   "A"ssymetry, "B"order irregularity, "C"olor, "D"iameter.  
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"Rule of 9's"   Divides body into 11 areas - each 9% total plus 1% genital.  
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Partial-Thickness Burns   1st & 2nd Degree Burns  
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Full-Thickness Burns   3rd Degree Burns - Entire skin layers burned.  
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Eschar   Burned Skin.  
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Burns are considered critical when?   1. Over 25% are 2nd degree, 2) Over 10% are 3rd degree & 3) Facial, hands/feet have 3rd degree.  
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Epidermis, dermis & hypodermis derrived from?   Mesoderm  
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Lanugo Coat   Furry coat on fetus.  
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Vernix Caseosa   Cheesy-like coating on newborn.  
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Matrix Metalloproteinases   Enzymes that degrade collagen.  
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Decubitus Ulcer   Localized ulceration of skin due to lack of blood supply.  
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Epidermolysis bullosa (EB)   Hereditary disorders of keratin, collagen, or basement membrane - lack of cohesion between skin & mucosa. "Touch-me-nots".  
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Impetigo   Raised lesions around mouth & nose - staph infection.  
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Mongolian Spot   Blue-black spot in sacral region.  
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Porphyria   Alergic to sun - Lesions form - gums degerate & teeth prominent - vampire tales?  
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Sensations of touch & pressure picked up in which layer?   Dermis  
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Skin surface markings that reflect tight dermal attachments are?   Flexure Lines  
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The most dangerous skin cancer affects __ cells.   Melanocytes  
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The outtermost sheath of hair follicles are __.   Connective Root Sheath  
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The __ sweat glands are fairly unimportant in thermoregulation.   Apocrine  
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The destruction of the matrix of a hair bulb would result in its ability to __.   Grow hair  
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__ Must be activiated in the skin to enhance calcium metabolism.   Vitamin D  
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Bedsores are called __.   Decubitus ulcers  
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Addison Disease   Bronzing of skin - adrenal cortex is hypoactive.  
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Portion of hair w/in follicle is __.   Root  
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Epithelial Membrane   Simple organ - epithelial sheet bound to connective tissue proper.  
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__ membranes line closed ventral cavity of body.   Serous membranes  
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3 examples of serous membranes.   Peritoneums, pericardia & plurae  
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Mucus membranes are comprised of __.   Epithelial cells resting on a layer of loose connective tissue (lamina propria).  
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__ line all cavities that open to the body exterior.   Mucosa  
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In most cases, mucosa are "__" membranes.   "Wet"  
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Serous membranes are also __ membranes.   Epithelial  
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In serous membranes the __ layer lines a body cavity.   Parietal layer  
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In serous membranes __ layer covers the outside of the organs in a cavity.   Visceral  
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__ membranes line body cavities that are closed to the exterior.   Serous  
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Which serous membranes open to the exterior?   Female peritoneal cavity & dorsal body cavity  
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__ membranes line interior of blood vessels & the heart.   Serous  
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The entire wall of capillaries are composed of __.   Serosa  
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__ membranes are composed entirely of connective tissue.   Synovial  
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