BIO201 - Ch 5 - Integumentary System - Marieb/Hoehn - Rio Salado
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Skin is composed of 2 regions. | Epidermis & dermis.
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The __ is composed of epithelial cells & is outermost shield of body. | Epidermis.
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The __ makes up the bulk of skin. | Dermis.
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The dermis is made up of __. | Fibrous connective tissue.
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Vascularized layer of skin. | Dermis layer
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How do nutrients reach the epidermis? | Diffusing through tissue fluid from blood vessels in dermis.
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Subcutaneous tissue just deep to skin. | Hypodermis layer.
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Is not really part of skin but shares in protective functions. | Hypodermis
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Another name for the hypodermis is __. | Superficial fascia
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The superficial fascia (hypodermis) is __. | Superficial to connective tissue wrapping (fascia) of skeletal muscles.
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They hypodermis layer contains __ tissue. | Adipose tissue.
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The role of the hypodermis is? | Anchors skin to muscles, but is loose enough to slide.
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The fatty composition of the hypodermis acts as __ & __. | Shock absorber & insulator.
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Which layer thickens when we gain weight? | Hypodermis because of adipose tissue there.
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The epidermis layer is made of __. | Keratinized stratified squamous epithelium.
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The epidermis has __ cell types and __ to __ distinct layers. | 4 cell types & 4-5 layers.
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Most epidermal cells are __. | Keratinocytes.
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Keratin | Helps give epidermis its protective properties.
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Keratinocytes | Produce keratin & are tightly connected.
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4 Types of cells in epidermis are __. | Keratinocytes, melanocytes, Merkel, & Langerhans' Cells.
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Keratinocytes arise in the deepest epidermis called __. | Stratum basale.
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Keratinocytes undergo almost continuous __. | Mitosis
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We have a new epideris every __ days. | 25-45 days.
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Melanocytes | Spider-shaped epithelial cells - make melanin.
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Melanocytes are found __. | In deepest layer of epidermis.
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Melanin accumulates in __. | Melanosomes.
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Melanosomes | Membrane-bound granules that store melanin.
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Melanin is taken up by __. | Keratinocytes
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Langerhans' cells | Star-shaped phagocytes - help in immune sys - form network.
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Merkel cells | Associated w/merkel disk & nerve endings.
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Merkel disk | Sensory receptor for touch.
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Langerhans' cells - aka __. | Epidermal dendric cells.
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Thick skin has __ layers. | 5
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Which layer is absent in "thin" skin? | Stratum Lucidum
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Name the 5 skin layers acronym. | "Children Love Grammy's Special Brownies!"
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Skin layers from top to bottom are __? | Corneum, Lucidum, Granulosum, Spinosum, Basale.
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Which skin layer is known as the "horny layer"? | Stratum Corneum
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Stratum Corneum | 3/4 of epidermal thickness - Keratin - Glycolipids waterproof the layer.
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Which skin layer is waterproofed by glycolipids? | Stratum Corneum.
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Stratum Lucidum | "Clear Layer" - flat dead keratinocytes - parallel arrays of keratin filaments.
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Which layer of epidermis is called the "clear layer"? | Stratum Lucidum because of the the clear, flat, dead, keratinocytes.
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What granules are found in the Granulosum layer? | Keratohyaline & lamellated granules.
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Above which layer are cells unable to receive nutrition? | Stratum Granulosum
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Where will you find clear dead keratinocytes? | In the Stratum Lucidum.
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Stratum Spinosum | "Prickly Layer" - web-like intermediate filaments abundant in this level.
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Langerhans' cells are abundant in the __ layer. | The Stratum Spinosum.
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Stratum Basale | "Basal layers" - Deepest - attached to dermis - "stratum germinativum.
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Which epidermal layer has rapid division of keratinocytes? | Stratum Basale/Stratum germinativum.
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Keratohyaline Granules | Help form keratin in upper layers.
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Lamellated Granules | "Plated" - contain waterproofing glycolipid.
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Above which layer are epidermal cells not nurished? | Granulosum Layer
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Which cells are joined by desmosomes? | Keratinocytes
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Which layer has miotic stem cells? | Basale Layer
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Which skin region is called our "hide"? | Dermis.
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Dermis Layer | Lower skin region - flexible connective tissue - innervated & vascularized.
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Name the two dermis layers. | Papillary (superficial) & reticular (deeper) layer.
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Papillary Layer | Thin areolar conn. tissue - "peglike" projections.
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Papill | "Nipple".
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Dermal Papillae contain __. | Capillary loops, nerve endings, & messner's corpuscles.
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Dermal Ridges | Mounds of dermal tissue on which papillae lie.
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Epidermal Ridges | Lie atop dermal ridges & enhance gripping ability.
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Where do you find epidermal ridges? | Fingers & feet.
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Fingerprints are caused by? | Films of sweat secreted along epidermal ridges.
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Reticular Layer | 80% of dermis - deep - dense irregular conn. tiss. - Nurished by cutaneous plexus.
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Cleavage/Tension Lines | Less dense regions in dermis - lines that run longitudinally in skin.
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Flexure Lines | Dermal folds near or at joints.
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Striae | Stretch marks - "Streaks"
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3 Pigments that give skin its color are? | Melanin, carotene, & hemoglobin.
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Melanin | Polymer of tyrosine amino acids.
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Ultraviolet radiation destroys __ stores. | Folate - needed for DNA synthesis.
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Carotene | Yellow/orange pigment - accumulates in corneum.
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Cyanosis | Turning blue from lack of oxygen.
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Erythema indicates? | "Turning red" - fever, hypertension, inflammation or allergy.
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Pallor/blanching indicates? | Fear, anemia, low blood pressure.
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Bronzing indicates? | Hypofunction of adrenal cortex.
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Hematomoas | Clotted blood masses.
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What must form before a skin appendage can grow? | Epithelial bud
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What stimulates epithelial bud growth? | Reduced production of cadherin - breaks cell connections.
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Sudoriferous Gland | Sweat gland - 3 million.
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2 kinds of sweat glands are? | Eccrine & apocrine
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Eccrine Sweat Glands | "Merocrine" - Simple, coiled, tubular gland - opens to a pore.
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Sweat is? | Hypotonic filtrate of blood released by exocytosis. 99% h2O.
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Dermicidin | Microbe-killing peptide in sweat.
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pH of sweat? | Acidic - 4-5
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Sweating is regulated by? | Sympathetic Nervous System
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Apocrine Sweat Glands | Misnomer - actually secretes by exocytosis - In axillary & genital - body odor.
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What glands cause body odor? | Apocrine Sweat Glands
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Ceruminous Glands | Earwax - Cerumen secretions.
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Sebuceous Gland | Oil gland - simple, branched, alveolar, holcrine.
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The secretion of sebum is stimulated by __. | Sex Hormones - androgens
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Seborrhea | "Cradel Cap"
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Pili | Hair - hard keratin - keratinized
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Red hair is colored by __. | Iron-containing pigment trichosiderin.
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Arrector Pili | Smooth muscle cells around hair follicle - makes goose bumps
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2 types of hair are? | Vellus & terminal hair
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Vellus Hair | Fine - body hair
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Terminal Hair | Coarser, longer hair - pubic, axillary - response to sex hormones.
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Alopecia | Baldness
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Hirsutism | Excessive hormones
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Nail Matrix | Responsible for nail growth.
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Skin's 3 types of barriers. | Chemical, physical & melanin
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Acid mantle | Low pH of skin that retards bacterial multiplication.
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Human defensin | Natural antibiotics secreted by skin - punches holes in bacteria.
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Cathelicidins | Protective peptide secreted by wounded skin - good against Strep-A
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Physical/Mechanical Barriers | Provided by continuity of skin, harness of keratinized cells, & glycolipids.
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Biological Barriers | Langerhans' cells in epidermis, macrophages in dermis, & DNA.
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How does DNA protect the body? | Electrons in DNA absorb UV radiation & turn it into heat.
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Basal Cell Carcinoma | Most common skin cancer - 99% curable w/surgery.
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Cutaneous Sensory Receptors | Exteroceptors - Meissner's corpuscle, Merkel discs, & Pacinian.
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Metaboloic Functions of Skin | Synthesizes Vit. D, disarm cancer chemicals, activate steroid hormones.
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Fas | Protein that causes cell suicide.
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"ABCD" for Melanoma Recognition | "A"ssymetry, "B"order irregularity, "C"olor, "D"iameter.
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"Rule of 9's" | Divides body into 11 areas - each 9% total plus 1% genital.
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Partial-Thickness Burns | 1st & 2nd Degree Burns
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Full-Thickness Burns | 3rd Degree Burns - Entire skin layers burned.
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Eschar | Burned Skin.
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Burns are considered critical when? | 1. Over 25% are 2nd degree, 2) Over 10% are 3rd degree & 3) Facial, hands/feet have 3rd degree.
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Epidermis, dermis & hypodermis derrived from? | Mesoderm
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Lanugo Coat | Furry coat on fetus.
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Vernix Caseosa | Cheesy-like coating on newborn.
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Matrix Metalloproteinases | Enzymes that degrade collagen.
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Decubitus Ulcer | Localized ulceration of skin due to lack of blood supply.
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Epidermolysis bullosa (EB) | Hereditary disorders of keratin, collagen, or basement membrane - lack of cohesion between skin & mucosa. "Touch-me-nots".
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Impetigo | Raised lesions around mouth & nose - staph infection.
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Mongolian Spot | Blue-black spot in sacral region.
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Porphyria | Alergic to sun - Lesions form - gums degerate & teeth prominent - vampire tales?
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Sensations of touch & pressure picked up in which layer? | Dermis
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Skin surface markings that reflect tight dermal attachments are? | Flexure Lines
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The most dangerous skin cancer affects __ cells. | Melanocytes
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The outtermost sheath of hair follicles are __. | Connective Root Sheath
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The __ sweat glands are fairly unimportant in thermoregulation. | Apocrine
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The destruction of the matrix of a hair bulb would result in its ability to __. | Grow hair
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__ Must be activiated in the skin to enhance calcium metabolism. | Vitamin D
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Bedsores are called __. | Decubitus ulcers
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Addison Disease | Bronzing of skin - adrenal cortex is hypoactive.
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Portion of hair w/in follicle is __. | Root
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Epithelial Membrane | Simple organ - epithelial sheet bound to connective tissue proper.
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__ membranes line closed ventral cavity of body. | Serous membranes
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3 examples of serous membranes. | Peritoneums, pericardia & plurae
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Mucus membranes are comprised of __. | Epithelial cells resting on a layer of loose connective tissue (lamina propria).
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__ line all cavities that open to the body exterior. | Mucosa
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In most cases, mucosa are "__" membranes. | "Wet"
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Serous membranes are also __ membranes. | Epithelial
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In serous membranes the __ layer lines a body cavity. | Parietal layer
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In serous membranes __ layer covers the outside of the organs in a cavity. | Visceral
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__ membranes line body cavities that are closed to the exterior. | Serous
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Which serous membranes open to the exterior? | Female peritoneal cavity & dorsal body cavity
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__ membranes line interior of blood vessels & the heart. | Serous
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The entire wall of capillaries are composed of __. | Serosa
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__ membranes are composed entirely of connective tissue. | Synovial
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