Reversible cellular changes and accumulations
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| What are three ways that abnormal cellular accumulation can happen? | 1. Abnormal metabolism (fatty LV) 2. Def of critical enzymes t breakdown substances (accumulates in lysosomes) 3. Inability to degrade phagocytosed particles (carbon pigment accumulation)
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| Where is fatty change most often seen? | the Liver
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| What is the most common etiology of accumulation in the Liver? | Alcohol
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| What is the pathogenesis of lipid accumulation in the Liver? | 1. Increased synthesis of triglycerides 2. Decreased mobilization of triglycerides (protein malnutrition)
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| What would a liver with lipid accumulation look like to the naked eye? | enlarged, yellow, and greasy
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| What is the etiology of lipid accumulation in the heart? | prolonged hypoxia; toxic myocardia
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| What would a heart look like with accumulation to the naked eye? | soft, flabby; yellow bands alternating w/ normal red brown uninvolved bands
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| In atherosclerosis cholesterol accumulates where? | Smooth muscle cells and macrophages
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| In hyperlipidemia cholesterol accumulates where? | sub epithelial connective tissue--> yellowish plaque; commonly around the eyes
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| In foci of cell injury lipid debris are what? | Phagocytosed--> lipid-laden macrophages (foam)
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courtney.marie23
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