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Pathology Ch. 3

Reversible cellular changes and accumulations

What are three ways that abnormal cellular accumulation can happen? 1. Abnormal metabolism (fatty LV) 2. Def of critical enzymes t breakdown substances (accumulates in lysosomes) 3. Inability to degrade phagocytosed particles (carbon pigment accumulation)
Where is fatty change most often seen? the Liver
What is the most common etiology of accumulation in the Liver? Alcohol
What is the pathogenesis of lipid accumulation in the Liver? 1. Increased synthesis of triglycerides 2. Decreased mobilization of triglycerides (protein malnutrition)
What would a liver with lipid accumulation look like to the naked eye? enlarged, yellow, and greasy
What is the etiology of lipid accumulation in the heart? prolonged hypoxia; toxic myocardia
What would a heart look like with accumulation to the naked eye? soft, flabby; yellow bands alternating w/ normal red brown uninvolved bands
In atherosclerosis cholesterol accumulates where? Smooth muscle cells and macrophages
In hyperlipidemia cholesterol accumulates where? sub epithelial connective tissue--> yellowish plaque; commonly around the eyes
In foci of cell injury lipid debris are what? Phagocytosed--> lipid-laden macrophages (foam)
Created by: courtney.marie23



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