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skin, bones, muscles, joints

Quiz yourself by thinking what should be in each of the black spaces below before clicking on it to display the answer.
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Question
Answer
Layers of epidermis   stratum basale, spinosum, granulosum, lucidum, corneum  
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Post-mitotic layer of epidermis   stratum granulosum  
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layer of epidermis found only in skin that is very thick   stratum lucidum  
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layer of epidermis with squamous cells and no nuclei or other organelles   stratum lucidum  
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Attach to desmosomes   tonofibrils  
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Hold cells of stratum spinosum together   spiny projections  
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Cells that make up stratum spinosum   prickle cells  
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Contains the vascular system in the skin   dermis  
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Connects skin to underlying tissue   hypodermis  
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Main cell of the stratum basale   keratinocyte  
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Attaches basale to basement membrane   hemidesmosomes  
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Sensor cells in stratum basale   merkel cells  
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Levels of the epidermis most prone to cancer   stratum basale and stratum spinosum  
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Begins vitamin D synthesis   keratinocytes  
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Layers of the dermis   reticular and papillary  
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Dense irregular connective tissue in the dermis   Reticular layer  
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Areolar (loose) connective tissue in the dermis   Papillary layer  
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Contains Meissner's corpuscles   dermal papilla  
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Contains Pacinian corpuscles   Reticular layer of dermis  
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downward folds of the epidermis   rete ridges  
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upward projections of the dermis   dermal papilla  
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Enable friction to pick up small things   rete ridges  
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3 layers of hair   cortex, medulla, cuticle  
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Phase of hair growth that takes weeks to years   active phase  
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phase of hair growth that is 1-3 months then replaces old hair   resting phase  
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phase where hair matrix of cells die   regressive phase  
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sweat gland with watery secretions   merocrine  
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sweat gland with viscid secretion   apocrine  
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gland that helps with thermoregulation   merocrine  
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gland with stem cells   holocrine  
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gland with bigger lumen   aprocrine  
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gland that secretes by exocytosis   merocrine  
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gland that destroys the whole cell then secretes   holocrine  
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cancer that originates in the spinosum   squamous cell carcinoma  
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most common and least malignant cancer   basal cell carcinoma  
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slow growing cancer   basal cell carcinoma  
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most dangerous cancer because it is highly metastatic   melanoma  
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cancer caused by environmental factors   squamous cell carcinoma  
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cancer that appears as a lesion   squamous cell carcinoma  
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cancer that originates in stratum spinosum   squamous cell carcinoma  
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Cancer that appears as a brown/black patch   melanoma  
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Estimates the volume of fluid lost in burns   Rule of Nines  
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How long is burned skin sterile?   24 hours  
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Burn where only the epidermis is damaged   first degree burn  
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Burn that involves the dermis and epidermis; skin grafting necessary   3rd degree burn  
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Burn that is like first degree but with blisters   2nd degree burn  
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Silicone epidermis bound to spongy dermal layer with collagen and ground cartilage   synthetic skin  
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cartilage with a high water content   skeletal cartilage  
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3 types of skeletal cartilage   fibrocartilage, elastic cartilage, hyaline cartilage  
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Most common skeletal cartilage   hyaline  
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cartilage with collagen and elastic fibers   elastic cartilage  
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Growth from within   interstitial growth  
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Only skeletal cartilage with no perichondrium   fibrocartilage  
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Cartilage in nasal septum, trachea, ends of rubs   hyaline  
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Growth from edges   appositional  
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Collagen fibers are oriented in the direction of functional stress   fibrocartilage  
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Growth where chondroblasts in periosteum secrete a new matrix   appositional growth  
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Growth where chondrocytes divide to secrete new matrix   interstitial growth  
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Connected with skeleton by being in intevertebral discs   fibrocartilage  
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Bones in the skull, vertebral columns, and ribs   axial skeleton  
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Bones of upper and lower limbs   appendicular skeleton  
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Supports the weight of the upper body   pelvic girdle  
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Permits a wide range of motion   pectoral girdle  
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Site of leg attachment   pelvic girdle  
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Middle/shaft of bone   diaphysis  
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Plate that is usually from adult bone   epiphyseal plate  
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Marrow in adults   yellow  
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3 types of vertebrae   cervical, thoracic, lumbar  
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How many cervical vertebrae?   7  
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how many thoracic vertebrae?   12  
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How many lumbar vertebrae?   5  
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Vertical channels in bone that makes arteries and veins go through   Haversian canals  
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Horizontal channels that connect haversian canals   Volkmann's Canal  
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Connects lacunae to each other   canaliculi  
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Partial osteon   interstitial lamella  
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Spicules that make up spongy bone   trabeculae  
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Align lines of stress and help bone resist stress   trabeculae  
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25% of total bone organic material   collagen  
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Mineral component of bone   hypoxyapetite  
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Matured bone is 65%:   mineralized matrix  
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Provides tensile strength and flexibility   fibrous component  
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Trigger for bone crystallization   interaction of collagen fibers with GAGs of matrix material  
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Intramembranous ossification begins with:   mesenchyme  
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Endochondral ossification begins with:   hyaline cartilage  
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Ossification in long bones   endochondral ossification  
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Ossification in flat bones   intramembranous ossification  
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Ossification that goes straight to osteoblasts   intramembranous ossification  
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ossification that goes from chondroblasts to osteoblasts   endrochondral ossification  
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ossification surrounded by periosteum   intramembranous ossification  
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covers bone ends and articulations   hyaline cartilage  
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cells that have to die before osteoblasts come in during endochondral ossification   chondroblasts  
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Most important stimulus of epiphyseal plate   growth hormone  
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induce epiphyseal plates to completely ossify   estrogen and testosterone  
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Modulates growth hormone   T3 & T4  
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Growth in thickness of bone by:   appositional growth  
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Osteogenic layer of periosteum has:   osteoblasts  
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Released if blood calcium is too high   PTH  
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released if blood calcium is too low   calcitonin  
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Released from thyroid gland to regeulate calcium   calcitonin  
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Law that proves bones remodel because of mechanical stress   Wolffs law  
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Converts callus into bone in bone repair   osteoblasts  
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Increase at fracture site will increase bone growth:   electrical stimulus  
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How does electrical stimulus increase bone growth?   partially prevents PTH from stimulating osteoclasts  
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Ossification that is replacing cartilage with bone   Endochondral ossification  
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Biodegradable ceramic substance known as TCP   artificial bone  
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Used from human cadavers in bone repair   crushed bone  
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Caused by insufficient calcium or vitamin D   Rickets  
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Disease caused by excessive and abnormal bone resorption and formation   Paget's disease  
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Primary bone   woven bone  
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secondary bone   compact bone  
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Abnormally high woven bone to compact bone   Paget's disease  
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Bone disease that occurs at any age because of immobility   Disuse osteoporosis  
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Drugs that slow how much bone is dissolved   Anti-resorptive drugs  
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How often is the entire skeleton replaced   Every 10 years  
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Used for treatment of skeletal defects   crushed bone  
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Looks at bone density to diagnose osteoporosis earlier   DEXA  
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Age of peak bone mass   18 years old  
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Bone disease with unknown cause but linked to a viral infection   Paget's  
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4 hormones that regulate calcium   PTH, calcitonin, Vitamin D, Calcium  
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Slow how much bone gets dissolved   Anti-resorptive drugs  
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Class of anti-resorptives   biphosphates  
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Prevents further bone loss and increases bone density   biphosphates  
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Gets into osteoclast and causes it to self-destruct   biphosphate  
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Induces osteoclasts to dissolve bone   PTH  
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Inhibits collagen synthesis by osteoblasts   PTH  
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Increases calcium absorption in the body   PTH  
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Pathway of vitamin D   sun>skin (vitamin D3)>liver(calcidiol)>kidney(calcitriol)  
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Calcitriol acts as a:   hormone  
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Acts directly on the small intestine to boost absorption of calcium   Vitamin D  
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Increases calcium resorption (release) from skeleton   calcitriol  
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acts by binding to RANKL and stimulates differentiation into osteoclasts   calcitriol  
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Causes reabsorption of calcium by kidneys   Calcitriol  
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Macrophages that get differentiated   osteoclasts  
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Govern production of osteoclasts using 3 signaling molecules   osteoblasts  
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Induces macrophages to multiply   stimulating factor  
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protein that binds to macrophages inducing them to form osteoclasts   RANKL  
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attaches to RANKL so it won't bind to a macrophage   osteoprotegerin  
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Enhances osteoprotegerin   estrogen  
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Prolongs the life of osteoblasts   estrogen  
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Only occur between bones of the skull   sutures  
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Joints with no joint cavity   fibrous joints  
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Articulation edges completely filled by very short connective tissue fibers that penetrate the bone   sutures  
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Suture at border of parietal bones   serrate  
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suture between temporal and parietal bones   lap suture  
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suture in palatine process of maxilla   plane  
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Arrangement that allows infant's head to pass through birth canal   free-floating bones skull separated by sutures  
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Premature fusing of the sutures   craniosynostosis  
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Union of 2 or more bones to form single bones   synostosis  
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Types of fibrous joints   sutures, sydesmoses, gomphoses  
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Fibrous joint in which bones are connected by a ligament   syndesmoses  
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Fibrous joint with longer fibers   syndesmoses  
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Fibrous connection like a nail or a bolt with short peridontal ligament   gomphoses  
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movement of gomphoses   amphiarthrotic  
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slightly moveable joint   amphiarthrotic  
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immovable joint   synarthrotic  
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freely movable joints   diarthrotic  
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Diaphysis growing is called   synchondroses  
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Lack a joint cavity   cartilaginous joints  
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movement of cartilaginous joints   amphiarthrotic  
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types of cartilaginous joints   synchondroses and symphyses  
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Means growing together   symphysis  
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Becomes ossified and immovable (synarthrotic) when bone growth ends   synchondroses  
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Articular surfaces of bone are covered with   hyaline cartilage  
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Function of symphysis   strength and flexibility  
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Located predominantly in limbs   synovial joints  
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Filled with synovial fluid   joint cavity  
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joint enclosed by double-layered articular capsule   synovial joint  
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In synovial joints, comes from filtration of blood plasma   synovial fluid  
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Makes synovial fluid viscous   synovial membrane cells secrete hyaluronic acid  
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Makes synovial fluid slippery   albumin  
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Warms synovial fluid   exercise  
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Forces synovial fluid from cartilages when joint is suppressed by movement   weeping lubrication  
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Contains phagocytic cells that rid the joint cavity of cellular debrus and nourish cartilage   synovial fluid  
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layers of periosteum   fibrous layer and osteogenic layer  
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layer of periosteum containing osteoblasts   osteogenic layer  
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Bone growth in width b   appositional growth  
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Fibrous sacs lined with synovial membrane   Bursa  
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Contains thin film of synovial fluid and is common where ligaments, etc rub bone   Bursa  
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Elongated bursa that completely wrap around tendon subjected to friction   tendon sheaths  
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discs or wedges of fibrocartilage that separate articular surfaces of bone   menisci  
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divide synovial cavity into 2 separate cavities   menisci  
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absorbs shock and pressure, improves fit between bones, and stabilizes joints   menisci  
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Most menisci injuries occur _________ and are irreparable   in avascular zones  
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Loss of as little as 10% of meniscus can lead to:   degenerative arthritis  
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Treatment of choice for torn menisci   arthroscopy  
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Stability of joint depends on:   nature of articular surface and number & position of ligaments  
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What kind of sockets are best for stability?   deep sockets like the hip  
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low levels of contractile activity in relaxed muscle that keeps the muscles healthy and ready to react to stimuli   muscle tone  
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Most important stabilizing factor   muscle tendons that cross the joint  
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Monitor position of joints and maintains muscle tone   articular capsule and ligaments  
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Supplies articular capsule and ligaments   sensory nerve endings  
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Muscles always in what state   somewhat contractive  
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Every muscle is attached to the bone by at least ____ points   2  
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Attached to bone that does not move   origin  
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attached to bone that moves   insertion  
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What happens to insertion and origin when muscles contract   insertion moves toward the origin  
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Movement of every synovial joint   diarthrotic (freely movable)  
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Classes of synovial joints   plane, hinge, pivot, saddle, ball & socket  
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Synovial joint with flat articular surfaces   Plane joint  
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Synovial joint in tarsals/carpals   plane joint  
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synovial joint that permits flexion and extension   hinge joint  
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synovial joint that is in knee and elbow   hinge joint  
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synovial joint that allows rotation   pivot joint  
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synovial joint that includes the axis and atlas   pivot joint  
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synovial joint with concave and convex articular surface shapes   saddle joint  
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synovial joint in thumbs   saddle joint  
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Synovial joint: articular surfaces fit together concave to convex   saddle joint  
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most freely moving synovial joint   ball and socket  
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three bones of the elbow   ulna, radius, humerus  
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joint between humerus and ulna   humeroulnar  
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joint between humerus and radius   humeroradial  
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joint between radius and ulna   radioulnar  
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lateral epicondylitis   tennis elbow  
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medial epicondylitis   golfer's elbow  
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can be caused by heavy work lifting at the elbow or repetitive movements at the wrist   tennis elbow  
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symptom is pain on the lateral epicondyl   tennis elbow  
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Tennis elbow treatment   ice, brace, stretches, steriod injections, surgery  
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Tennis elbow surgery   common extensor origin released from lateral epicondyle  
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Freely movable joint that has sacrificed stability for mobility   shoulder joint  
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Head of humerus is in:   glenoid cavity of scapula  
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3 bones of the shoulder   humerus (upper arm), scapula (shoulder blade), clavicle (collar bone)  
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shoulder joint replacement surgery is also called   shoulder arthroplasty  
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4 muscles and their tendons in rotator cuff   subscapalaris, supra spinatus, infra spinatus, teres minor  
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formed by articulation of spherical head of femur with deep cupped acebatabulum of coxal bone   hip joint  
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Provides most of the stability of a hip joint   deep socket that encloses the femoral head & the strong ligaments  
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contains an artery that takes arterial blood to head of femur   intracapsular ligament  
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largest most complex joint in the body   knee joint  
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4 bones of knee joint   tibia, femur, patella, fibula  
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2 joints in knee   femopatellar and tibiofemoral joint  
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joint in the knee that is a plane joint   femopatellar joint  
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joint in the knee that is a hinge joint   tibiofemoral joint  
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Intermediate between patella and lower end of femur   femopatellar joint  
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between femoral condyles above and c-shaped menisci of tibia below   tibiofemoral joint  
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at least ____ bursae associated with the knee   12  
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Knee muscles that go across the knee joint   quads and hamstrings  
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major stabilizing ligaments of the knee   ACL and PCL  
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Hold joints together in the knee   ligaments  
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Determining presence or absence of blood within joint can help diagnose ______ injury   ACL  
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initial treatment of ACL injury   ice, anti-inflammatories, physical therapy  
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Most common type of ACL reconstruction   harvesting the central third of the patellar tendon with a bone block at each end of the tendon graft  
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Tissue most vulnerable to injury   cartilaginous growth centers  
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Increases traction stress on growth centers during growth spurt   bones grow faster than tendon-muscle unit  
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chronic traction & stress at tibial tubercle apophysis due to repetitive activity and tight quads   osgood-schlatter injury  
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using a patellar strap can relieve pain from:   osgood schlatter injury  
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leads to cartilage swelling and cortical bone fragmentation   osgood schlatter injury  
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ligaments reiforcing joints are stretched and torn   sprain  
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common sprain sites   lumbar region of spine, ankle, and knee  
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Why is ligament repair slow   because ligaments are poorly vascularized  
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Repair for completely ruptured ligaments   surgery  
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implanted in torn ligament to form supporting mesh   carbon fibers  
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causes cartilage tearing   cartilage subjected to high pressure or twisting motion simultaneously  
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Why does cartilage stay torn   it is avascular and can't get sufficient nourishment  
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occurs when bones are forced out of normal position at a joint   dislocation  
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inflammation of bursa or tendon sheath caused by excessive stress friction or bacterial infection   bursitis/tendonitis  
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most wide spread crippling disease in US   arthritis  
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may result in formation of bony spurs due to increased friction   arthritis  
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acute arthritis usually caused by & treated with:   bacterial invasion, antibiotics  
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non-inflammatory type of arthritis, chronic arthritis   osteoarthritis  
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Caused by degeneration of joint over time through wear and tear   chronic arthritis  
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osteoarthritis not common in:   shoulder  
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crunching noise made by affected joints   creptitus  
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drugs that block the enzyme that creates the pain   NSAIDs  
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drugs that work together to treat chronic arthritis. "synergy"   motrin+tylenol  
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Arthritis that affects 3x as many women as men   Rheumetoid arthritis  
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autoimmune disease with suspected cause strep bacteria   rheumatoid arthritis  
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Arthritis that attacks the synovial membrane   rheumatoid arthrits  
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Blood cells and swollen membranes release chemicals into synovial fluid that break down or damage joint tissues   rheumatoid arthritis  
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systemic disease: can show up in other organs   rheumatoid arthritis  
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excessive amount of uric acids deposited as urate crystals in soft tissues   gout  
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arthritis more common in males   gout  
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Genetic factors in these diseases:   gout, rheumatoid arthritis, osteoporsis  
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cells that participate in every activity that requires movement   muscle cells  
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3 types of muscle   skeletal, cardiac, smooth  
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generates 3/4 heat for muscles   from body by muscle action  
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elongated and called fibers   muscle cells  
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immature muscle cell   myoblast  
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largest of muscle cell types   skeletal muscle  
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Muscle must rest after short periods of activity   skeletal  
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multinucleated muscle(s)   skeletal  
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uninucleated muscle(s)   cardiac, smooth  
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Makes up skeletal muscle:   muscle fibers, connective tissue, blood vessels, and nerve fibers  
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connective tissue that wraps each individual muscle fiber   endomysium  
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connective tissue that wraps bundles of muscle fibers (fasicles)   perimysium  
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connective tissue that wraps the whole muscle   epimysium  
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covers entire muscle and is located over the layer of epimysium   fascia  
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Muscle attachment where epimysium is fused to periosteum or perochondrium   direct muscle attachment  
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muscle attachment where muscle fascia extends beyond muscle as a rope-like tendon that anchors muscle to bone, cartilage, or another fascia   indirect muscle attachment  
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Fascicle arrangement: long axis of fascicle rubs with longitudinal axis of muscle   parallel  
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fascicle arrangement: fascicles are short and attach obliquely to central tendon running length of muscle   pinnate  
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Fascicles attach to one side of tendon   unipinnate  
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fascicles attach to central tendon opposite sides   bipinnate  
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fascicles attach to many tenons   multipinnate  
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fascicle arrangement: fascicles converge toward single tendon   convergent  
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Pectoralis major fascicle arrangement   convergent  
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fascicle arrangement: fascicles arranged in concentric circles   circular  
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In muscle cells, contains large amounds of stored glycogen myoglobin   sarcoplasm  
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80% of cell volume   myofibrils  
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thick filaments   myosin  
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thin filaments   actin  
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contractile proteins   myofilaments  
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filament that looks like a twisted double strand   thin filaments  
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contain active sites for myosin binding   thin filaments (actin)  
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2 regulatory proteins associated with actin   tropomyosin and troponin  
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control myosin-actin interaction   troponin and tropomyosin  
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each muscle fiber contains ___ axon   one  
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Troponin that binds to actin   TnI  
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troponin that binds to tropomyosin   TnT  
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troponin that binds to Ca++   TnC  
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Complex of 3 polypeptides   troponin  
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Align width of muscle cell so it appears striated   myofibrils  
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functional contractile unit of skeletal and cardiac muscle   sarcomere  
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What has to happen to muscles before they contract   innervation  
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normally covers up binding spot on actin filament   tropomyosin  
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binds with troponin to cause tropomyosin to expose actin binding site   calcium  
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stimulates skeletal muscle cells   motor neurons  
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2 types of excitable cells   neurons & muscle cells  
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opens ligand-gated sodium channels   ACh  
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diffusion of Na in cell reduces resting potential at that spot creating:   end plate potential  
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potential reduced to _________ for action potential to be generated in cell   threshold voltage  
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Sarcolemma is restored to initial polarized state   repolarization  
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Restores electrical condition of resting membrane   potassium diffuses from cell  
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Tubules surround each myofibril   sarcoplasmic reticulum  
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Large perpendicular cross channels in SR   terminal cisternae  
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regulate intercellular levels of Ca++   major role of SR  
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Formed at A-I band junction where sarcolemma penetrates the interior of the cell   t tubules  
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sequence of events in which the transmission of an action potential along the sarcolemma leads to contraction   excitation-contraction coupling  
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promotes formation of myosin cross bridges   calcium  
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Production ceases shortly after breathing stops   ATP  
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autoimmune disease that attacks and destroys ACh receptors located on muscle cells   myasthenia gravis  
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Cause of stiffness after death known as rigor mortis   ATP isn't being produced to detach myosin cross bridges  
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Poison that disrupts innervation by blocking ACh from attaching to receptors   curare  
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amount of tension generated by a muscle depends on how stretched or contracted it is before stimulated   length tension relationship  
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monitors and adjusts length of resting muscle to paintain partial contraction   nervous system  
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length of resting muscle to maintain partial contraction   muscle tone  
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Keeps a muscle firm, healthy, and ready to respond to stimulation   muscle tone  
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consists of motor neuron and all muscle cells it controls   motor unit  
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large motor units generate ____ force but ____ control   more;less  
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time between stimulation and time of contraction (everything that happens before contraction place)   latent period  
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time during which the muscle contracts and actin filaments move   period of contraction  
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period in which muscle returns to original length; happens when trying to get myosin head off   period of relaxation  
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Period in which calcium goes to sarcoplasmic reticulum   period of relaxation  
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twitches vary with concentration of:   calcium  
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How does pH affect twitches   weaker  
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If a skeletal muscle is stimulated a second time right after contraction phase, contraction will have higher max tension   treppe  
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Successive stimuli arrive before the relaxation phase has been completed and second twitch is stronger   wave summation  
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wave summation can't happen under:   absolute refractory period  
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Required for wave summation   calcium  
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increasing the stimulation rate until the relaxation phase is eliminated   tetanus  
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Twitch seen in artificial stimulation of a muscle   tetanus  
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force exerted by a contracting muscle on an object   muscle tension  
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force exerted on a muscle by the weight of an object   load  
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muscle tension develops but the load is not moved   isometric  
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muscle tension develops and load is not moved (pushing and muscles are contracting but nothing happens)   isometric tension  
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muscle tension develops and the load is moved   isostonic tension  
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Borrow phosphate groups ATP needs to be made   phosphagen system  
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Respiration that doesnt require oxygen   anaerobic  
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Con of anaerobic respiration   glycolysis is converted to lactic acid when there is no oxygen available  
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Respiration that provides a large amount of ATP but takes longer because of the many steps   aerobic respiration  
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Main factor in muscle fatigue   making enough ATP  
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difference between resting rate of oxygen consumption and elevated rate   oxygen debt  
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muscle with poorly developed SR   smooth muscle  
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tiny invagnations of sarcolemma with calcium inside   caveloae  
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Why do calveolae work   smooth muscle has a large surface area so Ca++ can diffuse into cell from interstitial fluid  
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Muscle that lacks troponin and sarcomeres   smooth muscle  
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Organization of muscle fibers in smooth muscle   sheets of closely apposed fibers  
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cyclic contraction and relaxation of opposing layers allows lumen of organ to alternately constrict   peristalsis-smooth muscle  
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muscles that lack structured neuromuscular junction   smooth  
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innervating nerve fibers that have numerous bulbous endings   varicosities  
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neurotransmitters released in a wide synaptic cleft in general area of smooth muscle cells   diffuse junction  
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makes smooth muscle contractions possible   gap junctions  
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pacemaker cells   auto rhythmic cells  
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calcium interacts with ______ and _____ enzyme that are part of thich filament in smooth muscle contractions   calmodulin  
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why are smooth muscles always ready to contract   lack troponin  
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Smooth muscle contractions   Ca activates calmodulin>activates kinase enzyme>transfers ATP to myosin>myosin interacts with actin (contraction)  
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release neurotransmitters for involuntary muscles   autonomic nerve endings  
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allows hollow organs to fill or expand slowly to accomodate increased internal volume   stress-relaxation response  
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certain smooth muscle fibers divide to increase numbers, like uterus during pregnancy   hyperplasia  
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How can smooth muscle make its own connective tissue   can make collagen and elastic fibers to make CT that surround their fibers  
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