skin, bones, muscles, joints
Quiz yourself by thinking what should be in
each of the black spaces below before clicking
on it to display the answer.
Help!
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Layers of epidermis | stratum basale, spinosum, granulosum, lucidum, corneum
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Post-mitotic layer of epidermis | stratum granulosum
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layer of epidermis found only in skin that is very thick | stratum lucidum
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layer of epidermis with squamous cells and no nuclei or other organelles | stratum lucidum
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Attach to desmosomes | tonofibrils
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Hold cells of stratum spinosum together | spiny projections
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Cells that make up stratum spinosum | prickle cells
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Contains the vascular system in the skin | dermis
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Connects skin to underlying tissue | hypodermis
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Main cell of the stratum basale | keratinocyte
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Attaches basale to basement membrane | hemidesmosomes
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Sensor cells in stratum basale | merkel cells
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Levels of the epidermis most prone to cancer | stratum basale and stratum spinosum
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Begins vitamin D synthesis | keratinocytes
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Layers of the dermis | reticular and papillary
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Dense irregular connective tissue in the dermis | Reticular layer
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Areolar (loose) connective tissue in the dermis | Papillary layer
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Contains Meissner's corpuscles | dermal papilla
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Contains Pacinian corpuscles | Reticular layer of dermis
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downward folds of the epidermis | rete ridges
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upward projections of the dermis | dermal papilla
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Enable friction to pick up small things | rete ridges
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3 layers of hair | cortex, medulla, cuticle
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Phase of hair growth that takes weeks to years | active phase
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phase of hair growth that is 1-3 months then replaces old hair | resting phase
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phase where hair matrix of cells die | regressive phase
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sweat gland with watery secretions | merocrine
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sweat gland with viscid secretion | apocrine
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gland that helps with thermoregulation | merocrine
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gland with stem cells | holocrine
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gland with bigger lumen | aprocrine
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gland that secretes by exocytosis | merocrine
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gland that destroys the whole cell then secretes | holocrine
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cancer that originates in the spinosum | squamous cell carcinoma
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most common and least malignant cancer | basal cell carcinoma
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slow growing cancer | basal cell carcinoma
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most dangerous cancer because it is highly metastatic | melanoma
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cancer caused by environmental factors | squamous cell carcinoma
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cancer that appears as a lesion | squamous cell carcinoma
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cancer that originates in stratum spinosum | squamous cell carcinoma
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Cancer that appears as a brown/black patch | melanoma
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Estimates the volume of fluid lost in burns | Rule of Nines
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How long is burned skin sterile? | 24 hours
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Burn where only the epidermis is damaged | first degree burn
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Burn that involves the dermis and epidermis; skin grafting necessary | 3rd degree burn
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Burn that is like first degree but with blisters | 2nd degree burn
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Silicone epidermis bound to spongy dermal layer with collagen and ground cartilage | synthetic skin
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cartilage with a high water content | skeletal cartilage
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3 types of skeletal cartilage | fibrocartilage, elastic cartilage, hyaline cartilage
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Most common skeletal cartilage | hyaline
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cartilage with collagen and elastic fibers | elastic cartilage
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Growth from within | interstitial growth
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Only skeletal cartilage with no perichondrium | fibrocartilage
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Cartilage in nasal septum, trachea, ends of rubs | hyaline
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Growth from edges | appositional
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Collagen fibers are oriented in the direction of functional stress | fibrocartilage
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Growth where chondroblasts in periosteum secrete a new matrix | appositional growth
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Growth where chondrocytes divide to secrete new matrix | interstitial growth
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Connected with skeleton by being in intevertebral discs | fibrocartilage
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Bones in the skull, vertebral columns, and ribs | axial skeleton
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Bones of upper and lower limbs | appendicular skeleton
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Supports the weight of the upper body | pelvic girdle
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Permits a wide range of motion | pectoral girdle
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Site of leg attachment | pelvic girdle
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Middle/shaft of bone | diaphysis
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Plate that is usually from adult bone | epiphyseal plate
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Marrow in adults | yellow
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3 types of vertebrae | cervical, thoracic, lumbar
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How many cervical vertebrae? | 7
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how many thoracic vertebrae? | 12
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How many lumbar vertebrae? | 5
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Vertical channels in bone that makes arteries and veins go through | Haversian canals
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Horizontal channels that connect haversian canals | Volkmann's Canal
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Connects lacunae to each other | canaliculi
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Partial osteon | interstitial lamella
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Spicules that make up spongy bone | trabeculae
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Align lines of stress and help bone resist stress | trabeculae
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25% of total bone organic material | collagen
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Mineral component of bone | hypoxyapetite
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Matured bone is 65%: | mineralized matrix
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Provides tensile strength and flexibility | fibrous component
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Trigger for bone crystallization | interaction of collagen fibers with GAGs of matrix material
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Intramembranous ossification begins with: | mesenchyme
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Endochondral ossification begins with: | hyaline cartilage
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Ossification in long bones | endochondral ossification
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Ossification in flat bones | intramembranous ossification
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Ossification that goes straight to osteoblasts | intramembranous ossification
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ossification that goes from chondroblasts to osteoblasts | endrochondral ossification
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ossification surrounded by periosteum | intramembranous ossification
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covers bone ends and articulations | hyaline cartilage
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cells that have to die before osteoblasts come in during endochondral ossification | chondroblasts
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Most important stimulus of epiphyseal plate | growth hormone
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induce epiphyseal plates to completely ossify | estrogen and testosterone
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Modulates growth hormone | T3 & T4
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Growth in thickness of bone by: | appositional growth
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Osteogenic layer of periosteum has: | osteoblasts
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Released if blood calcium is too high | PTH
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released if blood calcium is too low | calcitonin
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Released from thyroid gland to regeulate calcium | calcitonin
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Law that proves bones remodel because of mechanical stress | Wolffs law
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Converts callus into bone in bone repair | osteoblasts
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Increase at fracture site will increase bone growth: | electrical stimulus
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How does electrical stimulus increase bone growth? | partially prevents PTH from stimulating osteoclasts
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Ossification that is replacing cartilage with bone | Endochondral ossification
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Biodegradable ceramic substance known as TCP | artificial bone
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Used from human cadavers in bone repair | crushed bone
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Caused by insufficient calcium or vitamin D | Rickets
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Disease caused by excessive and abnormal bone resorption and formation | Paget's disease
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Primary bone | woven bone
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secondary bone | compact bone
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Abnormally high woven bone to compact bone | Paget's disease
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Bone disease that occurs at any age because of immobility | Disuse osteoporosis
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Drugs that slow how much bone is dissolved | Anti-resorptive drugs
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How often is the entire skeleton replaced | Every 10 years
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Used for treatment of skeletal defects | crushed bone
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Looks at bone density to diagnose osteoporosis earlier | DEXA
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Age of peak bone mass | 18 years old
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Bone disease with unknown cause but linked to a viral infection | Paget's
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4 hormones that regulate calcium | PTH, calcitonin, Vitamin D, Calcium
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Slow how much bone gets dissolved | Anti-resorptive drugs
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Class of anti-resorptives | biphosphates
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Prevents further bone loss and increases bone density | biphosphates
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Gets into osteoclast and causes it to self-destruct | biphosphate
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Induces osteoclasts to dissolve bone | PTH
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Inhibits collagen synthesis by osteoblasts | PTH
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Increases calcium absorption in the body | PTH
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Pathway of vitamin D | sun>skin (vitamin D3)>liver(calcidiol)>kidney(calcitriol)
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Calcitriol acts as a: | hormone
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Acts directly on the small intestine to boost absorption of calcium | Vitamin D
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Increases calcium resorption (release) from skeleton | calcitriol
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acts by binding to RANKL and stimulates differentiation into osteoclasts | calcitriol
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Causes reabsorption of calcium by kidneys | Calcitriol
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Macrophages that get differentiated | osteoclasts
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Govern production of osteoclasts using 3 signaling molecules | osteoblasts
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Induces macrophages to multiply | stimulating factor
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protein that binds to macrophages inducing them to form osteoclasts | RANKL
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attaches to RANKL so it won't bind to a macrophage | osteoprotegerin
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Enhances osteoprotegerin | estrogen
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Prolongs the life of osteoblasts | estrogen
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Only occur between bones of the skull | sutures
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Joints with no joint cavity | fibrous joints
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Articulation edges completely filled by very short connective tissue fibers that penetrate the bone | sutures
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Suture at border of parietal bones | serrate
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suture between temporal and parietal bones | lap suture
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suture in palatine process of maxilla | plane
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Arrangement that allows infant's head to pass through birth canal | free-floating bones skull separated by sutures
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Premature fusing of the sutures | craniosynostosis
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Union of 2 or more bones to form single bones | synostosis
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Types of fibrous joints | sutures, sydesmoses, gomphoses
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Fibrous joint in which bones are connected by a ligament | syndesmoses
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Fibrous joint with longer fibers | syndesmoses
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Fibrous connection like a nail or a bolt with short peridontal ligament | gomphoses
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movement of gomphoses | amphiarthrotic
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slightly moveable joint | amphiarthrotic
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immovable joint | synarthrotic
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freely movable joints | diarthrotic
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Diaphysis growing is called | synchondroses
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Lack a joint cavity | cartilaginous joints
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movement of cartilaginous joints | amphiarthrotic
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types of cartilaginous joints | synchondroses and symphyses
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Means growing together | symphysis
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Becomes ossified and immovable (synarthrotic) when bone growth ends | synchondroses
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Articular surfaces of bone are covered with | hyaline cartilage
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Function of symphysis | strength and flexibility
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Located predominantly in limbs | synovial joints
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Filled with synovial fluid | joint cavity
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joint enclosed by double-layered articular capsule | synovial joint
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In synovial joints, comes from filtration of blood plasma | synovial fluid
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Makes synovial fluid viscous | synovial membrane cells secrete hyaluronic acid
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Makes synovial fluid slippery | albumin
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Warms synovial fluid | exercise
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Forces synovial fluid from cartilages when joint is suppressed by movement | weeping lubrication
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Contains phagocytic cells that rid the joint cavity of cellular debrus and nourish cartilage | synovial fluid
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layers of periosteum | fibrous layer and osteogenic layer
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layer of periosteum containing osteoblasts | osteogenic layer
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Bone growth in width b | appositional growth
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Fibrous sacs lined with synovial membrane | Bursa
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Contains thin film of synovial fluid and is common where ligaments, etc rub bone | Bursa
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Elongated bursa that completely wrap around tendon subjected to friction | tendon sheaths
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discs or wedges of fibrocartilage that separate articular surfaces of bone | menisci
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divide synovial cavity into 2 separate cavities | menisci
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absorbs shock and pressure, improves fit between bones, and stabilizes joints | menisci
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Most menisci injuries occur _________ and are irreparable | in avascular zones
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Loss of as little as 10% of meniscus can lead to: | degenerative arthritis
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Treatment of choice for torn menisci | arthroscopy
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Stability of joint depends on: | nature of articular surface and number & position of ligaments
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What kind of sockets are best for stability? | deep sockets like the hip
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low levels of contractile activity in relaxed muscle that keeps the muscles healthy and ready to react to stimuli | muscle tone
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Most important stabilizing factor | muscle tendons that cross the joint
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Monitor position of joints and maintains muscle tone | articular capsule and ligaments
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Supplies articular capsule and ligaments | sensory nerve endings
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Muscles always in what state | somewhat contractive
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Every muscle is attached to the bone by at least ____ points | 2
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Attached to bone that does not move | origin
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attached to bone that moves | insertion
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What happens to insertion and origin when muscles contract | insertion moves toward the origin
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Movement of every synovial joint | diarthrotic (freely movable)
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Classes of synovial joints | plane, hinge, pivot, saddle, ball & socket
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Synovial joint with flat articular surfaces | Plane joint
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Synovial joint in tarsals/carpals | plane joint
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synovial joint that permits flexion and extension | hinge joint
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synovial joint that is in knee and elbow | hinge joint
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synovial joint that allows rotation | pivot joint
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synovial joint that includes the axis and atlas | pivot joint
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synovial joint with concave and convex articular surface shapes | saddle joint
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synovial joint in thumbs | saddle joint
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Synovial joint: articular surfaces fit together concave to convex | saddle joint
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most freely moving synovial joint | ball and socket
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three bones of the elbow | ulna, radius, humerus
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joint between humerus and ulna | humeroulnar
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joint between humerus and radius | humeroradial
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joint between radius and ulna | radioulnar
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lateral epicondylitis | tennis elbow
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medial epicondylitis | golfer's elbow
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can be caused by heavy work lifting at the elbow or repetitive movements at the wrist | tennis elbow
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symptom is pain on the lateral epicondyl | tennis elbow
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Tennis elbow treatment | ice, brace, stretches, steriod injections, surgery
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Tennis elbow surgery | common extensor origin released from lateral epicondyle
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Freely movable joint that has sacrificed stability for mobility | shoulder joint
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Head of humerus is in: | glenoid cavity of scapula
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3 bones of the shoulder | humerus (upper arm), scapula (shoulder blade), clavicle (collar bone)
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shoulder joint replacement surgery is also called | shoulder arthroplasty
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4 muscles and their tendons in rotator cuff | subscapalaris, supra spinatus, infra spinatus, teres minor
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formed by articulation of spherical head of femur with deep cupped acebatabulum of coxal bone | hip joint
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Provides most of the stability of a hip joint | deep socket that encloses the femoral head & the strong ligaments
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contains an artery that takes arterial blood to head of femur | intracapsular ligament
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largest most complex joint in the body | knee joint
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4 bones of knee joint | tibia, femur, patella, fibula
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2 joints in knee | femopatellar and tibiofemoral joint
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joint in the knee that is a plane joint | femopatellar joint
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joint in the knee that is a hinge joint | tibiofemoral joint
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Intermediate between patella and lower end of femur | femopatellar joint
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between femoral condyles above and c-shaped menisci of tibia below | tibiofemoral joint
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at least ____ bursae associated with the knee | 12
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Knee muscles that go across the knee joint | quads and hamstrings
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major stabilizing ligaments of the knee | ACL and PCL
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Hold joints together in the knee | ligaments
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Determining presence or absence of blood within joint can help diagnose ______ injury | ACL
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initial treatment of ACL injury | ice, anti-inflammatories, physical therapy
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|
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Most common type of ACL reconstruction | harvesting the central third of the patellar tendon with a bone block at each end of the tendon graft
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Tissue most vulnerable to injury | cartilaginous growth centers
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Increases traction stress on growth centers during growth spurt | bones grow faster than tendon-muscle unit
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chronic traction & stress at tibial tubercle apophysis due to repetitive activity and tight quads | osgood-schlatter injury
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||||
using a patellar strap can relieve pain from: | osgood schlatter injury
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||||
leads to cartilage swelling and cortical bone fragmentation | osgood schlatter injury
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ligaments reiforcing joints are stretched and torn | sprain
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common sprain sites | lumbar region of spine, ankle, and knee
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Why is ligament repair slow | because ligaments are poorly vascularized
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|
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Repair for completely ruptured ligaments | surgery
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|
||||
implanted in torn ligament to form supporting mesh | carbon fibers
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|
||||
causes cartilage tearing | cartilage subjected to high pressure or twisting motion simultaneously
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|
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Why does cartilage stay torn | it is avascular and can't get sufficient nourishment
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|
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occurs when bones are forced out of normal position at a joint | dislocation
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|
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inflammation of bursa or tendon sheath caused by excessive stress friction or bacterial infection | bursitis/tendonitis
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|
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most wide spread crippling disease in US | arthritis
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|
||||
may result in formation of bony spurs due to increased friction | arthritis
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|
||||
acute arthritis usually caused by & treated with: | bacterial invasion, antibiotics
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|
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non-inflammatory type of arthritis, chronic arthritis | osteoarthritis
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|
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Caused by degeneration of joint over time through wear and tear | chronic arthritis
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|
||||
osteoarthritis not common in: | shoulder
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|
||||
crunching noise made by affected joints | creptitus
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|
||||
drugs that block the enzyme that creates the pain | NSAIDs
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|
||||
drugs that work together to treat chronic arthritis. "synergy" | motrin+tylenol
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|
||||
Arthritis that affects 3x as many women as men | Rheumetoid arthritis
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|
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autoimmune disease with suspected cause strep bacteria | rheumatoid arthritis
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|
||||
Arthritis that attacks the synovial membrane | rheumatoid arthrits
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|
||||
Blood cells and swollen membranes release chemicals into synovial fluid that break down or damage joint tissues | rheumatoid arthritis
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systemic disease: can show up in other organs | rheumatoid arthritis
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|
||||
excessive amount of uric acids deposited as urate crystals in soft tissues | gout
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|
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arthritis more common in males | gout
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Genetic factors in these diseases: | gout, rheumatoid arthritis, osteoporsis
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cells that participate in every activity that requires movement | muscle cells
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3 types of muscle | skeletal, cardiac, smooth
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generates 3/4 heat for muscles | from body by muscle action
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elongated and called fibers | muscle cells
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immature muscle cell | myoblast
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largest of muscle cell types | skeletal muscle
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Muscle must rest after short periods of activity | skeletal
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multinucleated muscle(s) | skeletal
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uninucleated muscle(s) | cardiac, smooth
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Makes up skeletal muscle: | muscle fibers, connective tissue, blood vessels, and nerve fibers
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|
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connective tissue that wraps each individual muscle fiber | endomysium
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connective tissue that wraps bundles of muscle fibers (fasicles) | perimysium
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connective tissue that wraps the whole muscle | epimysium
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covers entire muscle and is located over the layer of epimysium | fascia
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||||
Muscle attachment where epimysium is fused to periosteum or perochondrium | direct muscle attachment
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muscle attachment where muscle fascia extends beyond muscle as a rope-like tendon that anchors muscle to bone, cartilage, or another fascia | indirect muscle attachment
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|
||||
Fascicle arrangement: long axis of fascicle rubs with longitudinal axis of muscle | parallel
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|
||||
fascicle arrangement: fascicles are short and attach obliquely to central tendon running length of muscle | pinnate
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|
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Fascicles attach to one side of tendon | unipinnate
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fascicles attach to central tendon opposite sides | bipinnate
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|
||||
fascicles attach to many tenons | multipinnate
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|
||||
fascicle arrangement: fascicles converge toward single tendon | convergent
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Pectoralis major fascicle arrangement | convergent
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fascicle arrangement: fascicles arranged in concentric circles | circular
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In muscle cells, contains large amounds of stored glycogen myoglobin | sarcoplasm
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80% of cell volume | myofibrils
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thick filaments | myosin
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thin filaments | actin
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contractile proteins | myofilaments
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filament that looks like a twisted double strand | thin filaments
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contain active sites for myosin binding | thin filaments (actin)
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2 regulatory proteins associated with actin | tropomyosin and troponin
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control myosin-actin interaction | troponin and tropomyosin
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each muscle fiber contains ___ axon | one
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Troponin that binds to actin | TnI
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troponin that binds to tropomyosin | TnT
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troponin that binds to Ca++ | TnC
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Complex of 3 polypeptides | troponin
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Align width of muscle cell so it appears striated | myofibrils
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functional contractile unit of skeletal and cardiac muscle | sarcomere
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What has to happen to muscles before they contract | innervation
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normally covers up binding spot on actin filament | tropomyosin
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binds with troponin to cause tropomyosin to expose actin binding site | calcium
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stimulates skeletal muscle cells | motor neurons
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2 types of excitable cells | neurons & muscle cells
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opens ligand-gated sodium channels | ACh
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diffusion of Na in cell reduces resting potential at that spot creating: | end plate potential
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potential reduced to _________ for action potential to be generated in cell | threshold voltage
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Sarcolemma is restored to initial polarized state | repolarization
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Restores electrical condition of resting membrane | potassium diffuses from cell
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Tubules surround each myofibril | sarcoplasmic reticulum
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Large perpendicular cross channels in SR | terminal cisternae
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regulate intercellular levels of Ca++ | major role of SR
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Formed at A-I band junction where sarcolemma penetrates the interior of the cell | t tubules
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sequence of events in which the transmission of an action potential along the sarcolemma leads to contraction | excitation-contraction coupling
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promotes formation of myosin cross bridges | calcium
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|
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Production ceases shortly after breathing stops | ATP
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|
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autoimmune disease that attacks and destroys ACh receptors located on muscle cells | myasthenia gravis
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|
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Cause of stiffness after death known as rigor mortis | ATP isn't being produced to detach myosin cross bridges
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|
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Poison that disrupts innervation by blocking ACh from attaching to receptors | curare
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|
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amount of tension generated by a muscle depends on how stretched or contracted it is before stimulated | length tension relationship
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|
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monitors and adjusts length of resting muscle to paintain partial contraction | nervous system
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length of resting muscle to maintain partial contraction | muscle tone
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Keeps a muscle firm, healthy, and ready to respond to stimulation | muscle tone
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consists of motor neuron and all muscle cells it controls | motor unit
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large motor units generate ____ force but ____ control | more;less
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time between stimulation and time of contraction (everything that happens before contraction place) | latent period
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|
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time during which the muscle contracts and actin filaments move | period of contraction
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|
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period in which muscle returns to original length; happens when trying to get myosin head off | period of relaxation
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|
||||
Period in which calcium goes to sarcoplasmic reticulum | period of relaxation
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|
||||
twitches vary with concentration of: | calcium
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|
||||
How does pH affect twitches | weaker
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|
||||
If a skeletal muscle is stimulated a second time right after contraction phase, contraction will have higher max tension | treppe
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|
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Successive stimuli arrive before the relaxation phase has been completed and second twitch is stronger | wave summation
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|
||||
wave summation can't happen under: | absolute refractory period
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|
||||
Required for wave summation | calcium
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|
||||
increasing the stimulation rate until the relaxation phase is eliminated | tetanus
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|
||||
Twitch seen in artificial stimulation of a muscle | tetanus
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|
||||
force exerted by a contracting muscle on an object | muscle tension
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|
||||
force exerted on a muscle by the weight of an object | load
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|
||||
muscle tension develops but the load is not moved | isometric
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|
||||
muscle tension develops and load is not moved (pushing and muscles are contracting but nothing happens) | isometric tension
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|
||||
muscle tension develops and the load is moved | isostonic tension
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|
||||
Borrow phosphate groups ATP needs to be made | phosphagen system
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|
||||
Respiration that doesnt require oxygen | anaerobic
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|
||||
Con of anaerobic respiration | glycolysis is converted to lactic acid when there is no oxygen available
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|
||||
Respiration that provides a large amount of ATP but takes longer because of the many steps | aerobic respiration
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|
||||
Main factor in muscle fatigue | making enough ATP
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|
||||
difference between resting rate of oxygen consumption and elevated rate | oxygen debt
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|
||||
muscle with poorly developed SR | smooth muscle
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|
||||
tiny invagnations of sarcolemma with calcium inside | caveloae
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|
||||
Why do calveolae work | smooth muscle has a large surface area so Ca++ can diffuse into cell from interstitial fluid
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|
||||
Muscle that lacks troponin and sarcomeres | smooth muscle
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|
||||
Organization of muscle fibers in smooth muscle | sheets of closely apposed fibers
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|
||||
cyclic contraction and relaxation of opposing layers allows lumen of organ to alternately constrict | peristalsis-smooth muscle
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|
||||
muscles that lack structured neuromuscular junction | smooth
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|
||||
innervating nerve fibers that have numerous bulbous endings | varicosities
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|
||||
neurotransmitters released in a wide synaptic cleft in general area of smooth muscle cells | diffuse junction
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|
||||
makes smooth muscle contractions possible | gap junctions
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|
||||
pacemaker cells | auto rhythmic cells
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|
||||
calcium interacts with ______ and _____ enzyme that are part of thich filament in smooth muscle contractions | calmodulin
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|
||||
why are smooth muscles always ready to contract | lack troponin
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|
||||
Smooth muscle contractions | Ca activates calmodulin>activates kinase enzyme>transfers ATP to myosin>myosin interacts with actin (contraction)
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|
||||
release neurotransmitters for involuntary muscles | autonomic nerve endings
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|
||||
allows hollow organs to fill or expand slowly to accomodate increased internal volume | stress-relaxation response
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|
||||
certain smooth muscle fibers divide to increase numbers, like uterus during pregnancy | hyperplasia
🗑
|
||||
How can smooth muscle make its own connective tissue | can make collagen and elastic fibers to make CT that surround their fibers
🗑
|
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