Pattern-Recognition Approach to Peripheral Neuropathy
Quiz yourself by thinking what should be in
each of the black spaces below before clicking
on it to display the answer.
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| Symmetric proximal and distal weakness with sensory loss | GBS, CIDP
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| Symmetric distal weakness with sensory loss | Drug-induced, toxic, and metabolic neuropathies; hereditary neuropathies; amyloidosis
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| Asymmetric distal weakness with sensory loss - multiple nerves | Vasculitis; HHNPP; infections such as leprosy, Lyme disease, sarcoidosis, and HIV
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| Asymmetric distal weakness with sensory loss - single nerve | Compressive mononeuropathy and radiculopathy
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| Asymmetric distal weakness without sensory loss | Motor neuron disease, multifocal motor neuropathy
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| Asymmetric proximal and distal weakness with sensory loss | Polyradiculopathy or plexopathy, meningeal carcinomatosis or lymphomatosis, HNPP, hereditary neuropathies
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| Symmetric sensory loss without weakness | Crytogenic sensory polyneuropathy; metabolic, drug-induced, or toxic neuropathies; leprosy
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| Asymmetric proprioceptive sensory loss without weakness | Sensory neuronopathies (ganglionopathies); consider paraneoplastic, Sjogren syndrome, vitamin B6 toxicity, HIV-related sensory neuronopathies, cis-platinum toxicity
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| Autonomic symptoms and signs | Diabetes mellitus, amyloidosis, GBS, vincristine, porphyria, HIV-related autonomic neuropathy, idiopathic pandysautonomia
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Created by:
megankirch
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