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of a long bone

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Answer
Longitudinal Growth   endochondral ossification at epiphyseal plates  
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Zone of Reserve Cartilage   next to epiphysis; irregularly scattered small chondrocytes; chondrocytes here anchor the epiphyseal plate to the epiphysis  
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Zone of Proliferating Cartilage   larger chondrocytes stacked like coins are seen; these chondrocytes undergo mitosis to make new chondrocytes causing expansion of the plate  
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Zone of Hypertrophic Cartilage   even larger chondorcytes occur in columns; here chondrocytes mature  
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Zone of Calcified Matrix   a few layers, mostly dead cells; osteoclasts break it down; osteoblasts from diphysis lay down bone with osteocytes trapped inside --the metaphysis is the region where calcified matrix is replaced by bone to form the epiphyseal line  
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Lengthwise Growth   evidence is the epiphyseal line 16-18 years of life- 20-25 is when epiphyseal cartilage is replaced by bone  
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Circumferential Bone Growth   intramembranous ossification; periosteal osteoblasts deposit new bone on the periosteal surface of the diaphysis; endosteal osteoclasts break down old bone (marrow cavity enlarges and minderal ions are released into the blood)  
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Created by: sc26
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