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Bone Growth

of a long bone

Longitudinal Growth endochondral ossification at epiphyseal plates
Zone of Reserve Cartilage next to epiphysis; irregularly scattered small chondrocytes; chondrocytes here anchor the epiphyseal plate to the epiphysis
Zone of Proliferating Cartilage larger chondrocytes stacked like coins are seen; these chondrocytes undergo mitosis to make new chondrocytes causing expansion of the plate
Zone of Hypertrophic Cartilage even larger chondorcytes occur in columns; here chondrocytes mature
Zone of Calcified Matrix a few layers, mostly dead cells; osteoclasts break it down; osteoblasts from diphysis lay down bone with osteocytes trapped inside --the metaphysis is the region where calcified matrix is replaced by bone to form the epiphyseal line
Lengthwise Growth evidence is the epiphyseal line 16-18 years of life- 20-25 is when epiphyseal cartilage is replaced by bone
Circumferential Bone Growth intramembranous ossification; periosteal osteoblasts deposit new bone on the periosteal surface of the diaphysis; endosteal osteoclasts break down old bone (marrow cavity enlarges and minderal ions are released into the blood)
Created by: sc26