Physiology and Pharmacology
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| show | Flux = diffusion constant x area x conc difference/thickness
Henry's law states the conc = a x pressure
Flux = d x a x area/thickness x pressure difference
D = d x a x area/thickness
Flux = D x pressure difference
D is 250 ml/min/kPa for O2
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| show | Blood comes into equilibrium with alveolar gas
Doubling diffusion capacity wont alter amount of gas exchanged
Doubling blood flow will double amount of gas exchanges
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| show | Partial pressure gradient remains essentially constant along capillary
Doubling blood flow wont change the amount of gas exchanged
Doubling diffusion capacity will double exchange
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| show | Diffusing capacity - larger = more likely to equilibrate
Speed of chemical reaction with blood
Solubility in blood B - larger D, larger B and less likely to get equilibrium as need to move more
Blood flow - faster flow less time to equilibrate
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| Inert gases | show 🗑
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| CO2 and O2 | show 🗑
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| show | Solubility in membrane greater than in blood
Diffusion limited
Can be used to measure diffusing capacity of lung as this affects rate of exchange
Measure gas uptake, conc in alveoli and venous blood
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| Speed of chemical reaction | show 🗑
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