Busy. Please wait.
Log in with Clever
or

show password
Forgot Password?

Don't have an account?  Sign up 
Sign up using Clever
or

Username is available taken
show password

Your email address is only used to allow you to reset your password. See our Privacy Policy and Terms of Service.


Already a StudyStack user? Log In

Reset Password
Enter the associated with your account, and we'll email you a link to reset your password.

Physiology and Pharmacology

Quiz yourself by thinking what should be in each of the black spaces below before clicking on it to display the answer.
        Help!  

Question
Answer
show Solute exchange -nutrition of tissue ad hormone/drug delivery - uses diffusion along conc gradient obeying Fick's law Fluid exchange - regulation of plasma and interstitial fluid volume - by bulk flow due to pressure gradients obeying starlings principle  
🗑
Classes of capillaries   show
🗑
show Provides a tortuous pathway for small hydrophobic solutes Interactions of proteins embedded in membranes forms a tight barrier between cells Not continuous - small gaps allow formation of narrow channels  
🗑
show Blocks protein access to the intercellular cleft Transmembrane proteins conjugated to sugar molecules Water and small molecules can move Proteins are repelled - 4-5nm gaps too small Hyaluronidase (released by macrophages) destroys this in inflammation  
🗑
Vesicle transport   show
🗑
Types of solutes   show
🗑
show Solute flux is proportional to diffusion coefficient, surface area and conc difference but inversely proportional to thickness Permeability is the diffusion flux/(area of membrane x conc difference) Diffusion flux = Permeability x area x conc difference  
🗑
show Increased blood flow Reduced interstitial concentration Reduce capillary permeability e.g. in response to shear stress Recruitment of capillaries  
🗑
show Less steep decay in luminal concentration - faster replenishment Lower interstitial conc Maintains concentration difference Increased flow increases shear stress that increases permeability  
🗑
Recruitment of capillaries   show
🗑
show A feature of lymphatic disorder, cardiac failure, renal failure, pleural effusions, peritoneal swelling and joint effusions Dysregulation of fluid exchange leads to accumulation  
🗑
Fluid absorption   show
🗑
show Cannulated artery of dog leg Injected saline or serum into the muscle With saline dilution of blood was seen Serum produced no change - proteins cannot be reabsorbed and maintain water in interstitial fluid  
🗑
What affects flow   show
🗑
show Flow = LpA[(Pc-Pi)-sigma(Pip-Pii)] Lp = hydraulic conductance of endothelium A = wall area Sigma = osmotic reflection coefficient (capillary is leaky so only a fraction of osmotic pressure is exerted)  
🗑
Medical importance of sigma   show
🗑
show Usually favour filtration and formation of lymph Increased imbalance causes oedema e.g. pulmonary oedema or mitral stenosis (due to increase in Pc or decrease in Pip) If blood pressure falls e.g. haemorrhage these favour absorption (Pc reduced)  
🗑
Causes of excessive capillary filtration   show
🗑


   

Review the information in the table. When you are ready to quiz yourself you can hide individual columns or the entire table. Then you can click on the empty cells to reveal the answer. Try to recall what will be displayed before clicking the empty cell.
 
To hide a column, click on the column name.
 
To hide the entire table, click on the "Hide All" button.
 
You may also shuffle the rows of the table by clicking on the "Shuffle" button.
 
Or sort by any of the columns using the down arrow next to any column heading.
If you know all the data on any row, you can temporarily remove it by tapping the trash can to the right of the row.

 
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.

  Normal Size     Small Size show me how
Popular Medical sets