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Physiology and Pharmacology

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Question
Answer
Cardiac innervation   show
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show Sympathetic - faster heart rate, faster conduction velocity, stronger contraction and faster relaxation Parasympathetic - slower heart rate, slower conduction velocity - may innervate ventricles but limited evidence  
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show Mainly on If, Ica and Ik - these control heart rate Increases these to give a faster pacemaker, upstroke and recovery  
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show Can activate K channels, causing hyperpolarisation Antagonises the sympathetic NS and opens IKACh, reducing heart rate and hyperpolarising membrane potential  
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show Lack of stabilising Ik - more positive and alterable resting potential Stabilised by IKACh Early pacemaker current - If Late pacemaker current - IcaT Upstroke - IcaL Recovery - Ik  
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Effect of beta receptors   show
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Effect of muscarinic receptors   show
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Positive ionotropic effects of sympathetic nerve stimulation   show
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Mechanism of beta adrenoreceptor stimulation   show
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Ionotropic effects of sympathetic nerve stimulation   show
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Evidence that IcaL is altered by PKA   show
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Role of protein phosphatase 2A   show
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show Frank starling mechanism Increase in venous return in exercise increases ventricular stretch This increases stroke volume and cardiac output  
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Roles of pharmacological compounds   show
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Targets for inotropic agents   show
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