Gastroenterology
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show | Diarrhea (often bloody); Fatigue (poss rel to anemia, not nec); wt loss; anorexia; N/V; crampy abdominal pain (d/t obstructive sx?)
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show | Any part of GI tract (most commonly terminal ileum); skip lesions; transmural
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Features of UC | show 🗑
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Specific clinical features of UC | show 🗑
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show | fistula: abscesses; more common at anus; strictures of the intestine; CRC risk increased if > 1/3 colon involved; smoking & CD: bad
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show | may involve any area; usu eye, skin, liver, and joints (arthralgias, AS)
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EIM: arthralgia Type 1: | show 🗑
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EIM: arthralgia Type 2: | show 🗑
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Primary sclerosing cholangitis (PSC) | show 🗑
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show | erythema nodosum; sx of Crohn dz. May require steroids
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Pyoderma gangrenosum | show 🗑
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IBD eye complications | show 🗑
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show | infxs diarrhea; ischemia (elderly, PVD, thrombosis); meds (PCN, NSAID, CellCept); diverticular dz; perianal fistula
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show | Combo of endoscopy, histology, radiography, labs & clinical data; Colonoscopy with ileal intubation & bx (should see chronic colitis/enteritis); Small bowel follow-through, enteroclysis (+/- CT), MR enterography
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show | often anemic (Fe def & chronic dz), leukocytosis, elevated CRP (CD); DO NOT ORDER serologies (ASCA, Cbir, OmpC & Crohns; p-ANCA & UC)
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Genl principles of tx of IBD | show 🗑
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show | ≤5 BM/day; no sx systemic toxicity; normal ESR
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show | >5 BM/day and <10lb wt loss; no sx systemic toxicity
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IBD tx options | show 🗑
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6MP/AZA MOA: | show 🗑
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show | CD/UC colitis >1/3 colon: colonoscopies starting 8 yrs from sx onset; q1-3 years; if comorbid PSC: immed start annual colonoscopy; FH also inc CRC risk
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show | necessitate colectomy.
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show | necessitate segmental resection in CD (try to avoid surg if poss in CD)
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show | frequent UTIs/pneumaturia (fistula to bladder); High fever/abd mass (abscess, liver abscess); severe abd pain (perf); N/V (obstruction); severe rectal pain (perirectal abscess)
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Managing IBD flares | show 🗑
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Granulomas on bx are highly suggestive of: | show 🗑
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show | thickened, matted bowel loops, intra-abdominal abscess
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show | Hourly BMs; toxic appearance, fever, tachy, Hct <25; 10-20lb wt loss
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Test of choice for UC | show 🗑
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Contraindicated in eval of acute UC: | show 🗑
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UC treatment | show 🗑
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UC tx if intractable: | show 🗑
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IBD and smoking | show 🗑
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Crohn Dz findings | show 🗑
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show | wide spectrum of necrotic inflam; IBD tx, topical tx, or poss colectomy; DO NOT Bx
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IBD eye complications | show 🗑
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IBD colon ca risk/surveillance | show 🗑
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Pseudopolyps in CD: | show 🗑
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Koilonychia = | show 🗑
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