Immunoglobulins, T-cells, Hypersensitivity Reactions
Quiz yourself by thinking what should be in
each of the black spaces below before clicking
on it to display the answer.
Help!
|
|
||||
|---|---|---|---|---|---|
| IgM | The first antibody produced in response to an antigen. Fixes complement. Does not cross the placenta.
🗑
|
||||
| IgG | The primary antibody in the secondary response (second-exposure). Opsonizes (coats) bacteria, fixes complement, thereby destroying the bacteria. Crosses the placenta.
🗑
|
||||
| IgA | Found in mucosal secretions (upper respiratory tract, genitourinary tract). Engages pathogens outside the body. Aggregated form activates the alternative pathway of complement activation only.
🗑
|
||||
| IgE | Mediates Type I hypersensitivity reaction by binding to antigens and the surface of mast cells and basophils, stimulating the release of histamine. Levels often elevated in helminth infections.
🗑
|
||||
| IgD | Membrane IgD is part of the functional B cell receptor on mature B cells.
🗑
|
||||
| Type I hypersensitivity reaction | Results from IgE-mediated release of inflammatory molecules such as histamine from mast cells and basophils, can manifest as an asthma attack, a local wheal-and-flare, or anaphylaxis.
🗑
|
||||
| Type 2 hypersensitivity reaction | Antibody and complement mediated, is cytotoxic in nature and occurs in autoimmune hemolytic anemia, Graves' disease, and myasthenia gravis.
🗑
|
||||
| Type 3 hypersensitivity reaction | Caused by immune complex deposition and subsequent complement activation, may be a complication of IV administration of antigenic medications (penicillin).
🗑
|
||||
| Type 4 hypersensitivity reaction | Cell mediated, results in a delayed (24 to 48 hour) response. It is mediated by T cells. Examples include transplant rejection, TB skin test, and contact dermatitis (poison ivy).
🗑
|
||||
| Tc cells (cytotoxic cells) | Executors of the cell-mediated arm of the acquired immune system.
🗑
|
||||
| Th cells (T-helper cells) | Coordinators of the acquired immune system. They decide whether to attack an invader with a predominantly cell-mediated or humoral (antibody-mediated) attack.
🗑
|
||||
| Th1 cells | Stimulate the cell-mediated arm of the acquired immune system by secreting IL-2 and λ-interferon, which stimulate the action of macrophages and Tc cells.
🗑
|
||||
| Th2 cells | Stimulate the humoral (antibody-mediated) arm of the acquired immune system by secreting IL-4 and IL-5, which stimulate B cells to make antibodies.
🗑
|
Review the information in the table. When you are ready to quiz yourself you can hide individual columns or the entire table. Then you can click on the empty cells to reveal the answer. Try to recall what will be displayed before clicking the empty cell.
To hide a column, click on the column name.
To hide the entire table, click on the "Hide All" button.
You may also shuffle the rows of the table by clicking on the "Shuffle" button.
Or sort by any of the columns using the down arrow next to any column heading.
If you know all the data on any row, you can temporarily remove it by tapping the trash can to the right of the row.
To hide a column, click on the column name.
To hide the entire table, click on the "Hide All" button.
You may also shuffle the rows of the table by clicking on the "Shuffle" button.
Or sort by any of the columns using the down arrow next to any column heading.
If you know all the data on any row, you can temporarily remove it by tapping the trash can to the right of the row.
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.
Normal Size Small Size show me how
Normal Size Small Size show me how
Created by:
golfspy
Popular Medical sets