Hemoglobin Disorders
Quiz yourself by thinking what should be in
each of the black spaces below before clicking
on it to display the answer.
Help!
|
|
||||
|---|---|---|---|---|---|
| What is Thalassemia? List three consequences from Thalassemia. | DIsorders resulting in underproduction of hemoglobin chains.
3 consequences:
1) Microcytic anemia,
2) Hypochromia,
3) ineffective erythropoiesis
🗑
|
||||
| Two types of Thalassemia | 1 - Alpha Thalassemia
2 - Beta Thalassemia
🗑
|
||||
| Three categories of Beta Thalassemia and its presentation. | 1 - Beta Thalassemia trait -> Increased HbA2 chain (A2 = alpha and delta chains)
2 - Beta Thalassemia intermedia -> Mixture of HbA2 and HbF
3 - Beta Thalassemia major = Cooley's Anemia -> main Hb is HbF (Fetal Hemoglobin)
🗑
|
||||
| Signs and Symptoms of Beta Thalassemia | 1) Splenomegaly
2) Severe Anemia
3) Bone deformity
4) Organ problems (CHF)
🗑
|
||||
| What do you look for in blood smear that indicates Thalassemia | 1) Target cells
2) Microcytic Anemia
3) Hypochromia
🗑
|
||||
| How many genes regulate alpha chains? | 4
🗑
|
||||
| Types of Alpha Thalassemia | 1) Silent Carrier - missing 1 - normal to mild
2) Trait - missing 2 - mild anemia
3) Hb H - missing 3 - moderate anemia with Hb H (hemoglobin with 4 beta chains)
4) Hydrops Fetalis - missing 4 -Lethal in uterine -> Stillbirth
🗑
|
||||
| What happens to fetus with Hydrops Fetalis? | Missing all alpha chain genes -> Gets Hb Bart's = 4 gamma chain hemoglobin -> Poor transport = tissue hypoxia -> Multiple organ failure -> Massive edema + hypoxic death
🗑
|
||||
| What two diseases fall under Sickle Cell Anemia? | Homozygous Sickle Cell Anemia (SS) + Sickle Beta Thalassemia (Bo)
🗑
|
||||
| When does Sickle Cell Hemoglobins depolymerize? | During de-oxygenated state
🗑
|
||||
| Factors that hemoglobin polymer depend on: | 1) Transit time through microcirculation
2) MCHC - dehydration can increase depolymerization
3) Amount of HbF in the cell - more HbF leads to less depolymerized Hbs
🗑
|
||||
| What does Howell Jolly Bodies indicate? | Howell Jolly Bodies are fragments of nucleus that is incompletely removed due to defect of the spleen.
🗑
|
||||
| List the treatments for Sickle Cell Disease | Hydration and Pain Control,
Folate,
Penicillin,
Hydroxyurea - increases HbF,
🗑
|
||||
| What is the name of the drug used for pain prevention in SCD? | Crizanlizumab (Criz)
🗑
|
Review the information in the table. When you are ready to quiz yourself you can hide individual columns or the entire table. Then you can click on the empty cells to reveal the answer. Try to recall what will be displayed before clicking the empty cell.
To hide a column, click on the column name.
To hide the entire table, click on the "Hide All" button.
You may also shuffle the rows of the table by clicking on the "Shuffle" button.
Or sort by any of the columns using the down arrow next to any column heading.
If you know all the data on any row, you can temporarily remove it by tapping the trash can to the right of the row.
To hide a column, click on the column name.
To hide the entire table, click on the "Hide All" button.
You may also shuffle the rows of the table by clicking on the "Shuffle" button.
Or sort by any of the columns using the down arrow next to any column heading.
If you know all the data on any row, you can temporarily remove it by tapping the trash can to the right of the row.
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.
Normal Size Small Size show me how
Normal Size Small Size show me how
Created by:
soobyung92
Popular Medical sets