FA Classic Findings
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Actinic keratosis | Often precedes squamous cell carcinoma
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Addison’s disease | 1° adrenocortical deficiency
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Albright’s syndrome | Polyostotic fibrous dysplasia, precocious puberty, café-au-lait spots, short stature, young girls
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Albuminocytologic dissociation | Guillain-Barré (↑ protein in CSF with only modest ↑ in cell count)
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Alport’s syndrome | Hereditary nephritis with nerve deafness
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Anti–basement membrane antibodies | Goodpasture’s syndrome
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Anticentromere antibodies | Scleroderma (CREST)
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Anti-double-stranded DNA antibodies (ANA antibodies) | SLE (type III hypersensitivity)
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Anti–epithelial cell antibodies | Pemphigus vulgaris
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Antigliadin antibodies | Celiac disease
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Antihistone antibodies | Drug-induced SLE
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Anti-IgG antibodies | Rheumatoid arthritis
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Antimitochondrial antibodies | 1° biliary cirrhosis
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Antineutrophil antibodies | Vasculitis
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Antiplatelet antibodies | Idiopathic thrombocytopenic purpura
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Arachnodactyly | Marfan’s syndrome
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Argyll Robertson pupil | Neurosyphilis
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Arnold-Chiari malformation | Cerebellar tonsillar herniation
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Aschoff bodies | Rheumatic fever
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Atrophy of the mammillary bodies | Wernicke’s encephalopathy
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Auer rods | Acute myelogenous leukemia (especially the promyelocytic type)
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Autosplenectomy | Sickle cell anemia
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Babinski’s sign | UMN lesion
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Baker’s cyst in popliteal fossa | Rheumatoid arthritis
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Bamboo spine on x-ray | Ankylosing spondylitis
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Bartter’s syndrome | Hyperreninemia
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Basophilic stippling of RBCs | Lead poisoning
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Becker’s muscular dystrophy | Defective dystrophin; less severe than Duchenne’s
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Bell’s palsy | LMN CN VII palsy
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Bence Jones proteins | Multiple myeloma (kappa or lambda Ig light chains in urine), Waldenström’s macroglobulinemia (IgM)
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Berger’s disease | IgA nephropathy
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Bernard-Soulier disease | Defect in platelet adhesion
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Bilateral hilar adenopathy, uveitis | Sarcoidosis
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Birbeck granules on EM | Histiocytosis X (eosinophilic granuloma)
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Bloody tap on LP | Subarachnoid hemorrhage
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Blue bloater | Chronic bronchitis
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Blue sclera | Osteogenesis imperfecta
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Blue-domed cysts | Fibrocystic change of the breast
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Boot-shaped heart on x-ray | Tetralogy of Fallot; RVH
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Bouchard’s nodes | Osteoarthritis (PIP swelling 2° to osteophytes)
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Boutonnière deformity | Rheumatoid arthritis
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Branching rods in oral infection | Actinomyces israelii
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Brown tumor of bone | Hemorrhage causes brown color of osteolytic cysts: 1. Hyperparathyroidism 2. Osteitis fibrosa cystica (von Recklinghausen’s disease)
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Bruton’s disease | X-linked agammaglobulinemia
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Budd-Chiari syndrome | Posthepatic venous thrombosis
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Buerger’s disease | Small/medium-artery vasculitis
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Burkitt’s lymphoma | 8:14 translocation; associated with EBV; “starry sky” appearance on histology
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Burton’s lines | Lead poisoning
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Café-au-lait spots on skin | Neurofibromatosis
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Caisson disease | Gas emboli
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Calf pseudohypertrophy | Duchenne’s muscular dystrophy
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Call-Exner bodies | Granulosa-theca cell tumor of the ovary
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c-ANCA, p-ANCA | Wegener’s granulomatosis, microscopic polyangiitis
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Cardiomegaly with apical atrophy | Chagas’ disease
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Cerebriform nuclei | Mycosis fungoides (cutaneous T-cell lymphoma)
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Chagas’ disease | Trypanosome infection
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Chancre | 1° syphilis (not painful)
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Chancroid | Haemophilus ducreyi (painful)
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Charcot’s triad | Multiple sclerosis (nystagmus, intention tremor, scanning speech), cholangitis (jaundice, RUQ pain, fever)
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Charcot-Leyden crystals | Bronchial asthma (eosinophil membranes)
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Chédiak-Higashi disease | Phagocyte deficiency
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Cherry-red spot on macula | Tay-Sachs, Niemann-Pick disease, central retinal artery occlusion
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Cheyne-Stokes respirations | Central apnea in CHF and ↑ intracranial pressure
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“Chocolate cysts” | Endometriosis (frequently involves both ovaries)
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Chronic atrophic gastritis | Predisposition to gastric carcinoma
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Chvostek’s sign | Hypocalcemia (facial muscle spasm upon tapping)
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Clear cell adenocarcinoma of the vagina | DES exposure in utero
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Clue cells | Gardnerella vaginitis
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Codman’s triangle on x-ray | Osteosarcoma
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Cold agglutinins | Mycoplasma pneumoniae, infectious mononucleosis
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Cold intolerance | Hypothyroidism
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Condylomata lata | 2° syphilis
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Continuous machinery murmur | Patent ductus arteriosus
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Cori’s disease | Debranching enzyme deficiency
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Cotton-wool spots | Chronic hypertension
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Cough, conjunctivitis, coryza + fever | Measles
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Councilman bodies | Toxic or viral hepatitis
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Cowdry type A bodies | Herpesvirus
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Crescents in Bowman’s capsule | Rapidly progressive crescentic glomerulonephritis
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Crigler-Najjar syndrome | Congenital unconjugated hyperbilirubinemia
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Curling’s ulcer | Acute gastric ulcer associated with severe burns
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Currant-jelly sputum | Klebsiella
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Curschmann’s spirals | Bronchial asthma (whorled mucous plugs)
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Cushing’s ulcer | Acute gastric ulcer associated with CNS injury
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D-dimers | DIC
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Depigmentation of neurons in substantia nigra | Parkinson’s disease (basal ganglia disorder––rigidity, resting tremor, bradykinesia)
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Dermatitis, dementia, diarrhea | Pellagra (niacin, vitamin B3 deficiency)
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Diabetes insipidus + exophthalmos + lesions of skull | Hand-Schüller-Christian disease
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Dog or cat bite | Pasteurella multocida
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Donovan bodies | Granuloma inguinale
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Dressler’s syndrome | Post-MI fibrinous pericarditis
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Dubin-Johnson syndrome | Congenital conjugated hyperbilirubinemia (black liver)
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Duchenne’s muscular dystrophy | Deleted dystrophin gene (X-linked recessive)
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Eburnation | Osteoarthritis (polished, ivory-like appearance of bone)
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Edwards’ syndrome | Trisomy 18 associated with rocker-bottom feet, low-set ears, heart disease
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Eisenmenger’s complex | Late cyanosis shunt (uncorrected L → R shunt becomes R → L shunt)
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Elastic skin | Ehlers-Danlos syndrome
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Erb-Duchenne palsy | Superior trunk (C5–C6) brachial plexus injury (“waiter’s tip”)
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Erythema chronicum migrans | Lyme disease
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Fanconi’s syndrome | Proximal tubular reabsorption defect
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“Fat, female, forty, and fertile” | Acute cholecystitis
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Fatty liver | Alcoholism
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Ferruginous bodies | Asbestosis
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Gardner’s syndrome | Colon polyps with osteomas and soft tissue tumors
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Gaucher’s disease | Glucocerebrosidase deficiency
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Ghon focus | 1° TB
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Gilbert’s syndrome | Benign congenital unconjugated hyperbilirubinemia
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Glanzmann’s thrombasthenia | Defect in platelet aggregation
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Goodpasture’s syndrome | Autoantibodies against alveolar and glomerular basement membrane proteins
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Gowers’ maneuver | Duchenne’s (use of patient’s arms to help legs pick self off the floor)
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Guillain-Barré syndrome | Idiopathic polyneuritis
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“Hair-on-end” (crew-cut) | β-thalassemia, sickle cell anemia (extramedullary hematopoiesis)
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appearance on x-ray |
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Hand-Schüller-Christian disease | Chronic progressive histiocytosis
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HbF | Thalassemia major
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HbS | Sickle cell anemia
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hCG elevated | Choriocarcinoma, hydatidiform mole (occurs with and without embryo)
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Heberden’s nodes | Osteoarthritis (DIP swelling 2° to osteophytes)
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Heinz bodies | G6PD deficiency
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Henoch-Schönlein purpura | Hypersensitivity vasculitis associated with hemorrhagic urticaria and URIs
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Heterophil antibodies | Infectious mononucleosis (EBV)
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High-output cardiac failure | Wet beriberi (thiamine, vitamin B1 deficiency)
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(dilated cardiomyopathy) |
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HLA-B27 | Reiter’s syndrome, ankylosing spondylitis
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HLA-DR3 or -DR4 | Diabetes mellitus type 1 (caused by autoimmune destruction of β cells)
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Horner’s syndrome | Ptosis, miosis, and anhidrosis
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Howell-Jolly bodies | Splenectomy (or nonfunctional spleen)
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Huntington’s disease | Caudate degeneration (autosomal dominant)
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Hyperphagia + hypersexuality + hyperorality + hyperdocility | Klüver-Bucy syndrome (amygdala)
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Hyperpigmentation of skin | 1° adrenal insufficiency (Addison’s disease)
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Hypersegmented neutrophils | Macrocytic anemia
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Hypertension + hypokalemia | Conn’s syndrome
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Hypochromic microcytosis | Iron deficiency anemia, lead poisoning
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Increased α-fetoprotein in amniotic fluid/maternal serum | Anencephaly, spina bifida (neural tube defects)
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Increased uric acid levels | Gout, Lesch-Nyhan syndrome, myeloproliferative disorders, loop and thiazide diuretics
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Intussusception | Adenovirus (causes hyperplasia of Peyer’s patches)
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Janeway lesions | Endocarditis
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Jarisch-Herxheimer reaction | Syphilis––overaggressive treatment of an asymptomatic patient that causes symptoms due to rapid lysis
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Job’s syndrome | Neutrophil chemotaxis abnormality
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Kaposi’s sarcoma | AIDS in MSM (men who have sex with men)
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Kartagener’s syndrome | Dynein defect
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Kayser-Fleischer rings | Wilson’s disease
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Keratin pearls | Squamous cell carcinoma
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Kimmelstiel-Wilson nodules | Diabetic nephropathy
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Klüver-Bucy syndrome | Bilateral amygdala lesions
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Koilocytes | HPV
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Koplik spots | Measles
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Krukenberg tumor | Gastric adenocarcinoma with ovarian metastases
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Kussmaul hyperpnea | Diabetic ketoacidosis
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Lens dislocation + aortic dissection + joint hyperflexibility | Marfan’s syndrome (fibrillin deficit)
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Lesch-Nyhan syndrome | HGPRT deficiency
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Lewy bodies | Parkinson’s disease
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Libman-Sacks disease | Endocarditis associated with SLE
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Lines of Zahn | Arterial thrombus
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Lisch nodules | Neurofibromatosis (von Recklinghausen’s disease)
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Low serum ceruloplasmin | Wilson’s disease
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Lucid interval | Epidural hematoma
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“Lumpy-bumpy” appearance of | Poststreptococcal glomerulonephritis
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glomeruli on immunofluorescence |
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Lytic bone lesions on x-ray | Multiple myeloma
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Mallory bodies | Alcoholic liver disease
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Mallory-Weiss syndrome | Esophagogastric lacerations
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McArdle’s disease | Muscle phosphorylase deficiency
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McBurney’s sign | Appendicitis
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MLF syndrome (INO) | Multiple sclerosis
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Monoclonal antibody spike | Multiple myeloma (called the M protein; usually IgG or IgA), MGUS (monoclonal
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gammopathy of undetermined significance), Waldenström’s (M protein = IgM)
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macroglobulinemia
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Myxedema | Hypothyroidism
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Necrotizing vasculitis (lungs) and | Wegener’s and Goodpasture’s (hemoptysis and glomerular disease)
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necrotizing glomerulonephritis |
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Needle-shaped, negatively | Gout
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birefringent crystals |
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Negri bodies | Rabies
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Nephritis + cataracts + hearing loss | Alport’s syndrome
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Neurofibrillary tangles | Alzheimer’s disease
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Niemann-Pick disease | Sphingomyelinase deficiency
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No lactation postpartum | Sheehan’s syndrome (pituitary infarction)
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Nutmeg liver | CHF
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Occupational exposure to asbestos | Malignant mesothelioma
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“Orphan Annie” nuclei | Papillary carcinoma of the thyroid
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Osler’s nodes | Endocarditis
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Owl’s eye | CMV
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Painless jaundice | Pancreatic cancer (head)
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Palpable purpura on legs and buttocks | Henoch-Schönlein purpura
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Pancoast’s tumor | Bronchogenic apical tumor associated with Horner’s syndrome
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Pannus | Rheumatoid arthritis
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Parkinson’s disease | Nigrostriatal dopamine depletion
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Periosteal elevation on x-ray | Pyogenic osteomyelitis
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Peutz-Jeghers syndrome | Benign polyposis
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“Pink puffer” | Emphysema (centroacinar [smoking], panacinar [α1-antitrypsin deficiency])
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“Smudge cell” | CLL
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“Strawberry tongue” | Scarlet fever
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“Tram-track” appearance on LM | Membranoproliferative glomerulonephritis
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“Wire loop” appearance on LM | Lupus nephropathy
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“Worst headache of my life” | Berry aneurysm––associated with adult polycystic kidney disease
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Philadelphia chromosome (bcr-abl ) | CML (may sometimes be associated with AML)
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Pick bodies | Pick’s disease
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Pick’s disease | Progressive dementia, similar to Alzheimer’s
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Plummer-Vinson syndrome | Esophageal webs with iron deficiency anemia
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Podagra | Gout (MP joint of hallux)
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Podocyte fusion | Minimal change disease
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Polyneuropathy preceded by GI or respiratory infection | Guillain-Barré syndrome
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Polyneuropathy, cardiac pathology, and edema | Dry beriberi (thiamine, vitamin B1 deficiency)
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Pompe’s disease | Lysosomal glucosidase deficiency associated with cardiomegaly
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Port-wine stain | Hemangioma
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Positive anterior “drawer sign” | Anterior cruciate ligament injury
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Pott’s disease | Vertebral tuberculosis
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Pseudopalisade tumor cell arrangement | Glioblastoma multiforme
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Pseudorosettes | Ewing’s sarcoma
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Ptosis, miosis, anhidrosis | Horner’s syndrome (Pancoast’s tumor)
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Rash on palms and soles | 2° syphilis, Rocky Mountain spotted fever
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Raynaud’s syndrome | Recurrent vasospasm in extremities
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RBC casts in urine | Acute glomerulonephritis
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Recurrent pulmonary Pseudomonas and S. aureus infections | Cystic fibrosis
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Red urine in the morning | Paroxysmal nocturnal hemoglobinuria
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Reed-Sternberg cells | Hodgkin’s lymphoma
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Reid index (increased) | Chronic bronchitis
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Reinke crystals | Leydig cell tumor
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Reiter’s syndrome | Urethritis, conjunctivitis, arthritis
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Renal cell carcinoma + cavernous hemangiomas + adenomas | von Hippel–Lindau disease
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Renal epithelial casts in urine | Acute toxic/viral nephrosis
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Rhomboid crystals, positively birefringent | Pseudogout
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Rib notching | Coarctation of aorta
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Roth’s spots in retina | Endocarditis
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Rotor’s syndrome | Congenital conjugated hyperbilirubinemia
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Rouleaux formation (RBCs) | Multiple myeloma
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S3 | Left-to-right shunt (VSD, PDA, ASD), mitral regurgitation, LV failure (CHF)
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S4 | Aortic stenosis, hypertrophic subaortic stenosis
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Schiller-Duval bodies | Yolk sac tumor
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Senile plaques | Alzheimer’s disease
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Sézary syndrome | Cutaneous T-cell lymphoma
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Sheehan’s syndrome | Postpartum pituitary necrosis
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Shwartzman reaction | Neisseria meningitidis
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Signet-ring cells | Gastric carcinoma
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Simian crease | Down syndrome
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Sipple’s syndrome | MEN type IIa
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Sjögren’s syndrome | Dry eyes, dry mouth, arthritis
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Skip lesions | Crohn’s
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Slapped cheeks | Erythema infectiosum (fifth disease)
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Smith antigen | SLE
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Soap bubble on x-ray | Giant cell tumor of bone
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Spike and dome on EM | Membranous glomerulonephritis
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Spitz nevus | Benign juvenile melanoma
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Splinter hemorrhages in fingernails | Endocarditis
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Starry-sky pattern | Burkitt’s lymphoma
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Streaky ovaries | Turner’s syndrome
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String sign on x-ray | Crohn’s disease
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Subepithelial humps on EM | Poststreptococcal glomerulonephritis
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Suboccipital lymphadenopathy | Rubella
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Sulfur granules | Actinomyces israelii
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Swollen gums, bruising, poor wound healing, anemia | Scurvy (ascorbic acid, vitamin C deficiency)––vitamin C is necessary for hydroxylation of proline and lysine in collagen synthesis
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Systolic ejection murmur (crescendo-decrescendo) | Aortic valve stenosis
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t(14;18) | Follicular lymphomas (bcl-2 activation)
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t(8;14) | Burkitt’s lymphoma (c-myc activation)
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t(9;22) | Philadelphia chromosome, CML (bcr-abl hybrid)
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Tabes dorsalis | 3° syphilis
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Tendon xanthomas (classically Achilles) | Familial hypercholesterolemia
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Thumb sign on lateral x-ray | Epiglottitis (Haemophilus influenzae)
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Thyroidization of kidney | Chronic bacterial pyelonephritis
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Tophi | Gout
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Trousseau’s sign | Visceral cancer, pancreatic adenocarcinoma (migratory thrombophlebitis), hypocalcemia (carpal spasm)
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Virchow’s node | Left supraclavicular node enlargement from metastatic carcinoma of the stomach
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Virchow’s triad | Pulmonary embolism (triad = blood stasis, endothelial damage, hypercoagulation)
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von Recklinghausen’s disease | Neurofibromatosis with café-au-lait spots
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von Recklinghausen’s disease of bone | Osteitis fibrosa cystica (“brown tumor”)
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Wallenberg’s syndrome | PICA thrombosis
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Waterhouse-Friderichsen syndrome | Adrenal hemorrhage associated with meningococcemia
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Waxy casts | Chronic end-stage renal disease
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WBC casts in urine | Acute pyelonephritis
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WBCs in urine | Acute cystitis
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Wermer’s syndrome | MEN type I
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Whipple’s disease | Malabsorption syndrome caused by Tropheryma whippelii
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Wilson’s disease | Hepatolenticular degeneration
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Xanthochromia (CSF) | Subarachnoid hemorrhage
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Xerostomia + arthritis + keratoconjunctivitis sicca | Sjögren’s syndrome
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Zenker’s diverticulum | Upper GI diverticulum
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Zollinger-Ellison syndrome | Gastrin-secreting tumor associated with ulcers
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Review the information in the table. When you are ready to quiz yourself you can hide individual columns or the entire table. Then you can click on the empty cells to reveal the answer. Try to recall what will be displayed before clicking the empty cell.
To hide a column, click on the column name.
To hide the entire table, click on the "Hide All" button.
You may also shuffle the rows of the table by clicking on the "Shuffle" button.
Or sort by any of the columns using the down arrow next to any column heading.
If you know all the data on any row, you can temporarily remove it by tapping the trash can to the right of the row.
To hide a column, click on the column name.
To hide the entire table, click on the "Hide All" button.
You may also shuffle the rows of the table by clicking on the "Shuffle" button.
Or sort by any of the columns using the down arrow next to any column heading.
If you know all the data on any row, you can temporarily remove it by tapping the trash can to the right of the row.
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Created by:
megankirch
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