ABIM NEP Intoxicants & Poisonings
Quiz yourself by thinking what should be in
each of the black spaces below before clicking
on it to display the answer.
Help!
|
|
||||
|---|---|---|---|---|---|
| Initial eval of pt with suspected intoxication/poisoning? | ABG, co-oximetry carboxyhemoglobin & methemoglobinemia, lytes (need AG), lactate and ketone levels, serum osmolality, tox screen
🗑
|
||||
| Charcoal lavage is useful for? | salicylates, phenobarbital, Theophylline, digoxin, phenytoin, carbamazepine, SR meds, drugs and slow G.I. motility (anti-cholinergics)… NOT for TCA.
🗑
|
||||
| Alkalinizing urine help intoxication by? | Best for salicylate and barbiturates. Promotes elimination of weak acid. Usu done with forced diuresis resulting in higher urine flow rate and reduced drug concentration that lowers gradient for reabsorption.
🗑
|
||||
| Useful antidote for acetaminophen? | - n-acetylcysteine
🗑
|
||||
| Useful antidote for carbon monoxide? | hyperbaric oxygen
🗑
|
||||
| Useful antidote for cyanide? | sodium thiosulfate
🗑
|
||||
| Useful antidote for digoxin? | Fab fragment
🗑
|
||||
| Useful antidote for methanol or ethylene glycol? |
🗑
|
||||
| Useful antidote for benzodiazepines? | flumazenil
🗑
|
||||
| Useful antidote for opiates? | naloxone
🗑
|
||||
| RRT vs HD for drug clearance? | HD is first line d/t higher clearance, but often us CRRT later to prevent rebound.
🗑
|
||||
| When is plasma exchange useful for drug clearance? | remove toxins from plasma only: amanita mushroom, digoxin, snake venom, cisplatin, biologics, cholinesterase with organophosphate poisoning. BUT does not affect acid-base or lytes.
🗑
|
||||
| Indications for dialysis in Lithium intoxication? | level > 4mmol/L; < 4 assoc w/ severe CNS symptoms, Low GFR, hemodynamic instability, level not falling in 12 hours. Level < 2.5 requires HD if lithium level rising for ESRD.
🗑
|
||||
| Dialysis prescription for lithium intoxication? | HD x 4 hrs (use pressers if needed), expect rebound and either dialyze again or start CRRT
🗑
|
||||
| Changes in the putamen assoc with _______ intoxication? | methanol
🗑
|
||||
| Renal effects of long term anabolic steroids? | FSGS
🗑
|
||||
| Drug associated with ANCA-vasculitis? | cocaine cut w levamisole. (usu MPO-ANCA ++ but half also PR3 +). Often develop low level auto immune ag.
🗑
|
||||
| Metformin causes ___ acidosis. | type B lactic acidosis, pH usu 6.75 and LA lvl 19!. Biguanides cause LA by impairing hepatic mitochondrial fcn.
🗑
|
||||
| Treatment of metformin induced lactic acidosis? | Rapidly reversed with iHD then CRRT to prevent rebound. Poorly protein bound. Alkalinization + loop diuretic useful for mild cases.
🗑
|
||||
| treatment of dabigatran OD? | Idarucizumab (Praxbind) is specific reversal agent, humanized Fab fragment. iHD partially useful followed by CRRT to manage rebound..
🗑
|
||||
| Melamine and the kidney | An organic nitrogenous compound deliberately added to milk to falsely elevate protein content, resulting in radiolucent stones, impaired renal function and growth
🗑
|
||||
| Environmental toxins causing albuminuria? | phthalates, bisphenol (BPA), dioxins, polychlorinated biphenyls (PCBs).
🗑
|
||||
| Toluene aka glue sniffing renal effects? | RTA, hypoK,hypophos, AKI, hematuria, sterile pyuria, proteinuria.
🗑
|
Review the information in the table. When you are ready to quiz yourself you can hide individual columns or the entire table. Then you can click on the empty cells to reveal the answer. Try to recall what will be displayed before clicking the empty cell.
To hide a column, click on the column name.
To hide the entire table, click on the "Hide All" button.
You may also shuffle the rows of the table by clicking on the "Shuffle" button.
Or sort by any of the columns using the down arrow next to any column heading.
If you know all the data on any row, you can temporarily remove it by tapping the trash can to the right of the row.
To hide a column, click on the column name.
To hide the entire table, click on the "Hide All" button.
You may also shuffle the rows of the table by clicking on the "Shuffle" button.
Or sort by any of the columns using the down arrow next to any column heading.
If you know all the data on any row, you can temporarily remove it by tapping the trash can to the right of the row.
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.
Normal Size Small Size show me how
Normal Size Small Size show me how
Created by:
ka1usg
Popular Medical sets