NSAIDs lecture notes
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| What is the mechanism of action of Aspirin? | It irreversity inhibits COX1 and COX2, thereby inhibiting PGI2(prostacyclin), PGE2(prostaglandins) and TXA2(THromboxane)
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| What is the clinical use of aspirin in low doses? | <300mg/day: dereases platelet aggregation
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| What is the clinical use of aspirin in intermediate doses? | 300-2400mg/day:antipyretic and analgesic
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| What is the clincial use of aspirin in high dosage? | anti-inflammatory
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| What are some of the side effects of aspirin? | Gastric upset, chronic use can lead to renal failure, interstitial nephritis and upper GI bleeding, Reyes syndrome.
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| What does PGI2(prostacyclin) do? | decreases platelet aggregation, vasodilation, decreases uterine tone
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| What does PGE2(prostaglandins) do? | decreases vascular tone, increases pain, uterine tone, and temperature
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| What does TXA2(Thromboxane) do? | Increases platelet aggregation and causes vasoconstriction
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| Name some of the traditional NSAIDs? | Ibuprofen, naproxen, indomethacin, ketorolac, diclofenac
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| What are the clinical uses of NSAIDs? | Antipyretic, analgesic, anti-inflammatory. Indomethacin is used to close a PDA.
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| What are the side effects of NSAIDs? | AntRenal damage, GI distress, ulcers, aplastic anemia
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| What is the name of the COX-2 inhibitor? | celecoxib
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| Is celecoxib better than aspirin in it's antiplatelet effect? | No
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| What is the MOA of celecoxib? | Inhibits COX-2 which is found on in inflammatory cells/vascular endothelium. Spares COX-1 which maintains the gastric mucosa - thus doesn't have the corrosive effects of other NSAIDS on the GI.
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| What is the usage of celecoxib? | RA and OA
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| What are the side effects of celecoxib? | increases risk of thrombosis, sulfa allergy, less toxicity to GI muosa
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