endonchondral ossification (major form)
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what bone of the body originate as hyaline cartilage | endochondral ossification
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what bone replaces the cartilage | endochondral ossification
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cartilage and chondrocytes in the shaft enlarges in what bones? | long bones
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in long bones the matrix is reduced to | small struts
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calcified struts isolate the ___ in long bones | chondrocytes
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chondrocytes die and disintegrate in | long bones
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bone formation occurs first on the __ | shaft surface
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cells of the innter layer of the cartilage covering (perichondrium) differentiate into what? | osteoblasts
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new blood vessels penetrate the cartilage to the ___ | central region
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what forms an ossification center within the bone? | new osteoblasts
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spongy bone spreads towards ___ | the end
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as the bone enlarges, osteoclasts erode the ___ | trabeculae
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secondary ossification centers from in the ___ | epiphyses
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epiphyses becomes filled with ___ | spongy bone
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a thin cap of the original cartilage remains exposed on the ends is called what? | articular cartilage
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at a metaphysis, a narrow cartilaginous region called the ___ separates the epiphysis from the diaphysis. | epiphyseal cartilage
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growth in length occurs from the ___ | epiphyseal cartilage
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cell division produces new cartilage, but at the border with diaphysis, older cartilage is broken down by invading osteoclasts (replaced with bone and medullary cavity expands) | epiphyseal cartilage
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as long as the epiphyseal cartilage continues to grow the bone will continue to ___ | grow in length
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