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2113L McKinney

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Term
Definition
plasma membrane / cell membrane   physical boundary separates the extracellular fluid surrounding the cell from the cell interior. Regulates movement of ions, molecules & other substances into & out of cell.  
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extracellular fluid   fluid outside the cell  
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nucleus   central structure that encases and proects the chromosomes; controls protein synthesis, gene action, cell division, metabolic rate  
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organelles   all internal structures  
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cytoplasm   volume inside the plasma membrane but outside the nucleus. Made up of solid components; organelles except nucleus; suspended in liquid - cytosol  
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cytosol   just the liquid part of cytoplasm  
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nonmembranous organelles   directly exposed to cytosol: ribosomes; microvilli; centrioles; cytoskeleton; cilia; and flagella  
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membranous organelles   enclosed in phospholipid membrane that isolates them from cytosol: nucleus; endoplasmic reticulum; Golgi apparatus; lysosomes; peroxisomes, mitochondria  
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microvilli   small folds in the plasma membrane that increase the surface area of the cell to absorb extracellular material, nutrients, at a greater rate  
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centrioles   paired organelles composed of microtubules which are small hollow tubes made of the protein tubulin; if cell division: replicate; one pair migrates to each pole of cell radiating spindle fibers from each that pull chromosomes of nucleus apart  
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centrosome   area surrounding the pair of centrioles in a cell. Cell not dividing: one pair; dividing cell: replicates - 2 pair.  
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cytoskeleton   made from microtubules; structural support and anchors organelles  
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cilia   short hair-like projections that extend from the plasma membrane. Common to respiratory and reproductive systems  
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flagellum   single, long projection for locomotion. Spermatozoon is the only human cell with it.  
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Ribosomes   direct protein synthesis; consists of 1 large & 1 small subunit that clamp around mRNA molecule to coordinate protein synthesis  
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Free ribosomes   occur in the cytoplasm  
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Fixed ribosomes   attached to the endoplasmic reticulum  
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chromatin   uncoiled chromosomes consisting of DNA and protein molecules; responsible for dark appearance of nucleus in stained specimen  
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nuclear envelope   surrounds the nuclear material; contains pores through which instruction molecules from nucleus pass into cytosol  
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nucleolus   produces ribosomal RNA molecules for the creation of ribosomes; darker stained region inside nucleus  
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Endoplasmic reticulum   surrounds the nucleus; functions in the synthesis of organic molecules, transport of materials within cell, storage of molecules. Materials may pass into Golgi apparatus for transport out of cell  
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rough ER   has ribosomes attached to surface; proteins produced in ribosomes on outer surface enter and assume the complex folded shape of ER.  
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Smooth ER   lacks ribosomes; involved in synthesis of many organic molecules such as cholesterol and phospholipids. in reproductive cells, it produces sex hormones; in liver cells synthesizes & stores glycogen; muscle & nerve cells - stores Ca++  
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Golgi apparatus   series of flattened saccules adjoining the ER; ER may pass protein molecules in transport vesicles here for modification & secretion; cell products such as mucus are synthesized, packaged and secreted by this  
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exocytosis   process where small secretory vesicles pinch off the saccules of the Golgi apparatus, fuse with the plasma membrane, then rupture; release contents into extracellular fluid. Phospholipid membranes of empty vesicles contribute to renewal of plasma membrane  
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lysosomes   vesicles produced by Golgi apparatus; filled with powerful enzymes that digest worn-out cell components & destroy microbes; some dissolved material is used to rebuild organelles. White blood cells trap bacteria & release these to digest bacteria  
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peroxisomes   vesicles filled with enzymes that break down fatty acids and other organic molecules; metabolize H2O2 - hydrogen peroxide into oxygen and water  
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mitochondria   produce useful energy; is wrapped in double layer phospholipid membrane. Inner layer is fingerlike (cristae). Metabolic enzymes passed along cristae to produce ATP. Muscles & nerve have many of these. Mature red blood cells lack & have low metabolic rate  
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mitosis   chromatin in the nucleus condenses into chromosomes & is equally divided between the two forming cells. each daughter cell has 23 pairs of chromosomes  
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cytokinesis   occurs toward end of mitosis; separates the cytoplasm to produce the two daughter cells  
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Interphase   most of the time cell is not dividing and is in interphase: carries out various functions and prepares for division; nucleus visible & darker nucleolus; G0 phase, G1 phase, S phase; G2 phase  
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G0 phase   cell performs its specialized functions; is not preparing to divide (interphase)  
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G1 phase   protein synthesis, growth, replication of organelles, including the centriole pair (interphase)  
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S phase   replication of DNA; afterward each chromosome is double stranded and consists of two chromatids; 1 chromatid is original strand, other is an identical copy. Chromatids held together by centromere (interphase)  
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G2 phase   another time for protein synthesis; by now replication of the centriole pair is complete  
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M phase   is the time of mitosis, nuclear material divides. Prophases; metaphase; anaphase; telophase  
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Prophase   chromosomes visible in nucleus; chromosomes start long & disorganized; nuclear envelope breaks down; chromosomes shorten, go to center; 2 centriole pairs start go opposite sides ; microtubules fan as spindle fibers from centrioles across cell. (mitosis)  
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Metaphase   chromosomes line up in middle at metaphase plate; spindle fibers across cell pole-to-pole & attach to centromeres of chromosomes; (mitosis)  
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Anaphase   separation of chromosomes! spindle fibers pull apart chromatids of chromosome, drag to opposite poles; individual chromatids = chromosomes; cleavage furrow develops; plasma membrane pinches; cytokinesis end of this phase (mitosis)  
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Telophase   cytokinesis partitions cytoplasm of cell; mitosis nears completion; each batch of chromosomes unwinds inside new nuclear envelope; each daughter has set organelles & nucleus with complete set of genes; daughter cells begin in interphase (mitosis)  
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