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Zoo141 (Uno) Study Guide

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Term
Definition
Epimysium   dense layer of collagen fibers surrounding entire skeletal muscle  
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Perimysium   fibrous layer that divides the skeletal muscle into fascicles (bundles of skeletal muscle fibers  
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Endomysium   delicate connective tissue surrounding individual muscle fibers  
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Tendon   bundle of collagenous connective tissue attaching muscle to bone  
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Aponeurosis   broad sheet of collagenous connective tissue attaching muscle to bone  
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Development of skeletal muscle fibers   myoblasts fuse into large multinucleate cells, which differentiate into skeletal muscle fibers (some myoblasts remain undifferentiated, as myosatellite cells)  
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Sarcolemma   plasma membrane  
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Sarcoplasm   cytoplasm  
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Myofibrils   bundles of protein filaments called myofilaments, which contain repeating functional unit called sarcomeres a. thin filaments: composed primarily of actin b. thick filaments: composed primarily of myosin  
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Transverse tubules (T tubules)   carry electrical activity from sarcolemma into cell interior  
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Sarcoplasmic reticulum (SR)   -carry electrical activity from sarcolemma into cell interior -stores and releases calcium, to start muscle contraction a. terminal cisternae = expanded chambers that contact T tubule, forming triad  
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A band   contains the entire width of the thick filaments  
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H band   contains the part of the thick filaments that does not overlap the thin filaments  
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I band   contains the part of the thin filaments that does not overlap the thick filaments  
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M line   connect the central portion of each thick filament  
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Z line   marks boundary between adjacent sarcomeres; consists of actinin proteins  
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G-actin (globular actin)   contains active sites that bind to myosin  
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F-actin (filamentous actin)   twisted strand composed of two rows of G-actin molecules  
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Nebulin   holds the F-actin strand together  
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Tropomyosin   strands that cover the active sites on G-actin  
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Troponin   has three subunits, that bind to tropomyosin, G-actin, and calcium  
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Myosin   has head that binds to thin filaments, and tail  
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Titin   forms core of thick filament  
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Structure of Neuromuscular   intercellular connection between muscle fiber and neuron  
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Synaptic Terminal of Neuron   contains vesicles filled with Ach  
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Motor End Plate of Muscle Fiber   has deep creases called junctional folds  
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Synaptic Cleft   space containing AChE (enzyme that breaks down ACh)  
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Latent Period   action potential sweeps across sarcolemma, SR releases Ca ions  
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Contraction Phase   tension rises to peak, as cross-bridge interactions occur  
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Relaxation Phase   tension decreases, as Ca levels fall, tropomyosin covers the active sites on actin, and myosin is blocked from binding to actin  
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Motor Unit   all the muscle fibers controlled by a single motor neuron  
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Isometric Contraction   muscle contraction without change in length  
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Isotonic contraction   muscle length changes during contraction a. concentric contraction: muscle shortens during contraction b. eccentric contraction: muscle lengthens during contraction  
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Sources of energy stored in a typical muscle fiber   1. ATP 2. Creatine Phosphate (CP) 3. Glycogen  
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ATP production in resting muscle   1. more than enough oxygen available for mitochondria 2. primary energy sources: glucose and fatty acids from blood enter mitochondria 3. surplus of ATP used to convert creatine to creatine phosphate, and glucose to glycogen  
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ATP production in muscle at peak activity levels   1. not enough oxygen available for mitochondria 2. primary energy sources: glucose from stored glycogen -> glycolysis (lactic acid also produced)  
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