Zoo141 (Uno) Study Guide
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Epimysium | dense layer of collagen fibers surrounding entire skeletal muscle
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Perimysium | fibrous layer that divides the skeletal muscle into fascicles (bundles of skeletal muscle fibers
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Endomysium | delicate connective tissue surrounding individual muscle fibers
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Tendon | bundle of collagenous connective tissue attaching muscle to bone
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Aponeurosis | broad sheet of collagenous connective tissue attaching muscle to bone
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Development of skeletal muscle fibers | myoblasts fuse into large multinucleate cells, which differentiate into skeletal muscle fibers (some myoblasts remain undifferentiated, as myosatellite cells)
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Sarcolemma | plasma membrane
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Sarcoplasm | cytoplasm
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Myofibrils | bundles of protein filaments called myofilaments, which contain repeating functional unit called sarcomeres
a. thin filaments: composed primarily of actin
b. thick filaments: composed primarily of myosin
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Transverse tubules (T tubules) | carry electrical activity from sarcolemma into cell interior
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Sarcoplasmic reticulum (SR) | -carry electrical activity from sarcolemma into cell interior
-stores and releases calcium, to start muscle contraction
a. terminal cisternae = expanded chambers that contact T tubule, forming triad
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A band | contains the entire width of the thick filaments
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H band | contains the part of the thick filaments that does not overlap the thin filaments
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I band | contains the part of the thin filaments that does not overlap the thick filaments
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M line | connect the central portion of each thick filament
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Z line | marks boundary between adjacent sarcomeres; consists of actinin proteins
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G-actin (globular actin) | contains active sites that bind to myosin
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F-actin (filamentous actin) | twisted strand composed of two rows of G-actin molecules
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Nebulin | holds the F-actin strand together
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Tropomyosin | strands that cover the active sites on G-actin
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Troponin | has three subunits, that bind to tropomyosin, G-actin, and calcium
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Myosin | has head that binds to thin filaments, and tail
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Titin | forms core of thick filament
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Structure of Neuromuscular | intercellular connection between muscle fiber and neuron
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Synaptic Terminal of Neuron | contains vesicles filled with Ach
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Motor End Plate of Muscle Fiber | has deep creases called junctional folds
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Synaptic Cleft | space containing AChE (enzyme that breaks down ACh)
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Latent Period | action potential sweeps across sarcolemma, SR releases Ca ions
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Contraction Phase | tension rises to peak, as cross-bridge interactions occur
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Relaxation Phase | tension decreases, as Ca levels fall, tropomyosin covers the active sites on actin, and myosin is blocked from binding to actin
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Motor Unit | all the muscle fibers controlled by a single motor neuron
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Isometric Contraction | muscle contraction without change in length
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Isotonic contraction | muscle length changes during contraction
a. concentric contraction: muscle shortens during contraction
b. eccentric contraction: muscle lengthens during contraction
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Sources of energy stored in a typical muscle fiber | 1. ATP
2. Creatine Phosphate (CP)
3. Glycogen
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ATP production in resting muscle | 1. more than enough oxygen available for mitochondria
2. primary energy sources: glucose and fatty acids from blood enter mitochondria
3. surplus of ATP used to convert creatine to creatine phosphate, and glucose to glycogen
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ATP production in muscle at peak activity levels | 1. not enough oxygen available for mitochondria
2. primary energy sources: glucose from stored glycogen -> glycolysis (lactic acid also produced)
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