Immunobullous Diseases
Quiz yourself by thinking what should be in
each of the black spaces below before clicking
on it to display the answer.
Help!
|
|
||||
|---|---|---|---|---|---|
| Skin Immune System (SIS) components ? | * Langerhans cells -- Keratinocytes -- T and B lymphocytes -- Macrophages -- Mast cells and other cell types
🗑
|
||||
| What are the role of the Langerhans Cells in the SIS ? | * Dendritic shaped cells that help in Antigen Presentation to T-Cells to activate the adaptive immune response...... * They are good at presenting bc they have MHC Class I & II, CD40, CAMs, and B7
🗑
|
||||
| What is the role of keratinocytes in the immunologic/inflammatory skin response ? | * Become activated, and respond by producing PG's and Pro-Inflam cyotkines (TNF, IL-1,6,8)
🗑
|
||||
| **Immunobullous Diseases** | **ALL have Blisters from Antibodies that Immunofluorescence
🗑
|
||||
| Intraepidermal Immunobullous Diseases = ? | * Pemphigus (most serious of the diseases)
🗑
|
||||
| Subepidermal Immunobullous Diseases = ? | * Bullous Pemphigoid (from IgG and complement)
.....* Epidermolysis bullosa acquisita – (assoc. with IBD).... * Dermatitis herpetiformis (IgA and Celiac Disease)
🗑
|
||||
| Pemphigus basics = ? | * See high in the Mediterranean and Jewish pop..... * Is the only epidermal one.... * See blisters on the skin and mucous membranes
🗑
|
||||
| Pemphigus MoA = ? | * Autoantibodies against keratinocyte antigens, components of the desmosomes
🗑
|
||||
| The 2 Types of Pemphigus = ? | * Pemphigus vulgaris = More severe and see on Skin AND Mucous membranes..... * Pemphigus foliaceus = skin issues and are a little more superficial blisters that involve autoantibodies are against Dsg1, NOT 1 and 3 like Vulgaris
🗑
|
||||
| What Immunofluorescence will show ? | * Greenish IgG fluorescence with a "Chicken Wire" appearance
🗑
|
||||
| Bullous Pemphigoid = ? | * subepidermal IgG and complement cause this ... * Don't pop as easily like Pemhigus.... * NO Oral involvement ... * See Large Tense blisters
🗑
|
||||
| Bullous Pemphigoid MoA = ? | * Antibody against keratinocyte antigens (specifically BPAG2 and BPAG1)
🗑
|
||||
| Bullous pemphigoid Immunofluorescence will show ? | * IgG immunoreactants to the ROOF(epidermal side) of the blister cavity
🗑
|
||||
| Dermatitis Herpetiformis basics = ? | * Intensely pruritic vesicles and see NO mucousal involvement.... * Lesions may appear as grouped symmetrically vesicles..... * Associated with CELIAC Disease, so if you see these, check for gluten insensitivity
🗑
|
||||
| Immunofluorescence of Dermatitis Herpetiformis = ? | * IgA deposits at dermal-epidermal junction and see a good number of neutrophils
🗑
|
||||
| Epidermolysis bullosa acquisita (EBA) = ? | * subepidermal blistering disease usually presenting in 4th to 6th decade.... * MoA = Target antigen is type VII collagen
🗑
|
||||
| Immunofluorescence of EBA = ? | * See fluorescence of the FLOOR (roof = bullous pemp.) b/c of the main target, which is Type VII collagen
🗑
|
||||
| Some Other Bullous Diseases = ? | * Mucous membrane pemphigoid -- Pemphigoid gestationis (pregnant ppl) -- Linear IgA bullous disease (similar to Derm. Herpat., but is NOT associated with Celiac Disease)
🗑
|
||||
| One that is most fatal if left untreated = ? | * Pemphigus, bc of sepsis
🗑
|
Review the information in the table. When you are ready to quiz yourself you can hide individual columns or the entire table. Then you can click on the empty cells to reveal the answer. Try to recall what will be displayed before clicking the empty cell.
To hide a column, click on the column name.
To hide the entire table, click on the "Hide All" button.
You may also shuffle the rows of the table by clicking on the "Shuffle" button.
Or sort by any of the columns using the down arrow next to any column heading.
If you know all the data on any row, you can temporarily remove it by tapping the trash can to the right of the row.
To hide a column, click on the column name.
To hide the entire table, click on the "Hide All" button.
You may also shuffle the rows of the table by clicking on the "Shuffle" button.
Or sort by any of the columns using the down arrow next to any column heading.
If you know all the data on any row, you can temporarily remove it by tapping the trash can to the right of the row.
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.
Normal Size Small Size show me how
Normal Size Small Size show me how
Created by:
thamrick800
Popular Medical sets