Ovarian Pathology
Quiz yourself by thinking what should be in
each of the black spaces below before clicking
on it to display the answer.
Help!
|
|
||||
|---|---|---|---|---|---|
| Cysts lined with an inner layer of granulosa cells and outer layer of theca internal cells that form during ovulation that are under < 3 cm ? | * cystic follicles
🗑
|
||||
| Over > 3 cm and over 3 cm WITH Luteinization ? | * follicular cysts .... * + LH = Luteal Cyst
🗑
|
||||
| Polycystic Ovarian Disease ? | * Numerous cystic follicles or follicle cyst, often associated with oligomenorrhea
.... * women have anovulation, obesity, and hirsutism
🗑
|
||||
| Polycystic Ovarian Disease & Cortical Stromal Hyperplasia Gross Morphology ? | * PCOS = see numerous clear, shiny cysts.... * Cortical = stromal prolif, with no cysts
🗑
|
||||
| Ovarian Tumors overview ? | * mostly benign and usu in younger women..... * Malignant Ovarian Cancer = less incidence than vaginal/cerival, but when we get it, it is WAY more deadly
🗑
|
||||
| Surface Epithelial-Stromal Tumor types and basics ? | * based on Differentiaion: Serous - Mucinous - endometrioid
....* and on extent of proliferation: Benign (adenoma), Borderline, and Malignant (adenocarcinoma)
🗑
|
||||
| Further classified based on cystic and/or fibrous features ? | * cystadenoma /cystadenocarcinoma (with cystic structures) --- cystadenofibroma (cyst and fibrous areas)--- adenofibroma (predominantly fibrous areas)
🗑
|
||||
| Surface epithelial tumors theory ? | * the derivation of mullerian epithelial tumors is the transformation of coelomic epithelium, which then incorporated into ovarian development and repro. development
🗑
|
||||
| Serous tumors = ? | * Most common malignant ovarian tumor, BUT most are benign or borderline.... * This is a BILATERAL OVARIAN tumor
🗑
|
||||
| Malignant Serous Tumors = ? | * Low grade = associated with serous borderline tumor mutations in KRAS and BRAF and RARE p53 mutation....... * High Grade = arise De Novo, mutations in BRCA1 and 2, with a COMMON p53 mutation
🗑
|
||||
| Reduces risk of Malignant Serous Tumors ? | * women over 40 who have taken oral contraceptives and have undergone tubal ligation have reduced risk
🗑
|
||||
| Mucinous Tumors ? | * Gross = looks like a dried sponge.... * UNILATERAL and are less common than serous, and happens in middle of life (NOT young).... * Have KRAS Mutations..... * gelatinous fluid... * Cysts are lined by tall, columnar epithelial cells with apical mucin
🗑
|
||||
| Pseudomyxoma peritonei = ? | * Clinical condition defined by extensive mucinous ascites, cystic epithelial implants on the peritoneal surfaces, adhesions and frequently mucinous tumor involving the ovaries
.... * thought to be cause by mucinous.... *
🗑
|
||||
| If bilat. presentaion of a mucinous tumor = ? | * bilateral presentation of mucinous tumors always requires exclusion of a non-ovarian origin --> Pseudomyxoma Peritonei
🗑
|
||||
| Endometrioid Tumors ? | * BILATERAL (40%) ...* benign and borderline endometrioid tumors.....* Gross = see solidand cystic areas.... * Histo = Tumor consists of tubular glands bearing a close resemblance to benign or malignant endo. –columnar cells secreting mucous onto surface
🗑
|
||||
| SUMMARY of Epithelial Cell Tumors ? | * Bilateral = Serous and Endo..... * Uni. = Mucinous..... * Most common is Serous.... * Serous is the only cuboidal epi, the rest are Columnar... * Mucinous = LARGE/MASSIVE Tumor.... * Age Group for all = 20+ yr olds
🗑
|
||||
| If CA-125 is measured = ? | * most common in serous and endometrioid, but not specific ot bs e Dx off of it, so use other tests..... * We use it once Dx is confirmed to check response to tmt and recurrences
🗑
|
||||
| Clear Cell Adenocarcinoma = ? | * Rare, but see clear cells, and when we see clear cells = really aggressive.... * Only a 65% - 5-year survival rate..... * associated with endometrioid carcinoma
🗑
|
||||
| Cystadenofibroma = ? | * Variants in which the fibrous stromal proliferation is more pronounced than that of the columnar lining epithelium
..... * Small and benign... * Can have Endo, Mucinous, and Serous
🗑
|
||||
| Brenner tumor = ? | * Classified as adenofibroma..... * Epithelial components consists of nests of transitional –type epithelium (epithelial cells resembling those lining the urinary bladder)
🗑
|
||||
| Teratoma basics ? | * Has a Mature Type = benign (has differentiated).... and Immature = is Malignant
🗑
|
||||
| Mature (Benign) Teratoma = ? | * see in YOUNG women of reproductive age..... *associated with inflammatory limbic encephalitis
....... * Tumors arise from an ovum after the first meiotic division
🗑
|
||||
| Immature Malignant Teratomas = ? | * Prepubertal adolescents and young women, mean age (18 yrs)
...... * The Tissue resembles embryonal and immature fetal tissue
..... * Can invade ovarian capsule and mets...* Grade based on % of immature epi found
🗑
|
||||
| Monodermal or Specialized Teratoma = ? | * Rare & Always UNILATERAL - 2 types ..... * Struma ovarii (most common) = has mature thyroid tissue and can cause hyperthy....* Ovarian carcinoid = from intestinal epithelium in ovary (have serotonin syndrome).....* strumal carcinoid- combo of both
🗑
|
||||
| Dysgerminoma = ? | * Ovarian counterpart of seminoma of the testis
..... * in 2nd and 3rd decades of womens life .... * Secretes HCG and may have syncitiotrophoblastic giant cells on histologic exam.... * 96% cure rate... * Common in Turners due to gonadal dysgenesis
🗑
|
||||
| Endodermal Sinus (Yolk Sac) Tumor = ? | * 2nd most common germ cell tumor... * Occurs in KIDS (know this pic.)...... * The tumor is rich in α-fetoprotein and α1 antitrypsin
....* rapidly developing pelvic mass with abdominal pain in children or young women.... * See Schiller-Duval Bodies
🗑
|
||||
| Choriocarcinoma = ? | * placental origin...* Most are mixed.... * See HIGH levels of HCG... * usu. unresponsive to radiation, and often fatal
🗑
|
||||
| The 3 Sex Cord-Stromal tumors ? | * Granulosa-theca cell tumors
--- Fibromas, thecomas and fibrothecomas
--- Sertoli-leydig cell tumors (androblastomas)
🗑
|
||||
| Granulosa-Theca Cell tumors = ? | * In adults we see more bleeding/spotting and even breast cysts..... *In girls, we see precocious puberty.... * Most occur Postmenopausal women....* SEs are from high estrogen production....* High incidence of recurrence...* Biomarker = High INHIBIN lvls
🗑
|
||||
| Morphology of Granulosa-Theca Cell Tumors = ? | * Call-Exner Bodies seen in purple slide, which look like flower looking things
🗑
|
||||
| Tumors arising in the ovarian stroma that are composed of either ? | * Fibroblasts- Fibromas
...... * plump spindle cells with lipid droplets- Thecomas
....... * or maybe Mixed- Fibrothecomas
🗑
|
||||
| Meigs syndrome = ? | * See: ovarian tumor - pleural effusion - ascites .... * when tumor is removed, effusion and ascites goes away
🗑
|
||||
| Morphology of Fibroma and Thecoma ? | * solid/spherical, with an intact ovarian serosa
🗑
|
||||
| Sertoli-Leydig Cell Tumors (Androblastoma) = ? | * In 2nd & 3rd decades..... * Unilat. & may resemble granulosa-theca cell tumors.... * Produce musculinization (the Virulizing Tumor)
.....* Gross: looks like a cross section of an orange....* see tubules w/sertoli cells or leydig cells mixed in stroma
🗑
|
||||
| Metastatic Tumors = ? | * common metastatic tumors in the ovary are derived from tumors of the mullerian origin..... * Most common extramullerian tumors that metastasize to the ovary are carcinomas of breast and GI are pseudomyxoma peritonei and Krukenberg Tumor
🗑
|
||||
| Krukenberg Tumor and Pseudomyxoma Peritonei = ? | * Pseudomyxoma Peritonei = from appendiceal tumors......... * Krukenberg Tumor = bilateral mets to ovary from GI origin, composed of signet-ring cancer cells (gastric cancer)
🗑
|
Review the information in the table. When you are ready to quiz yourself you can hide individual columns or the entire table. Then you can click on the empty cells to reveal the answer. Try to recall what will be displayed before clicking the empty cell.
To hide a column, click on the column name.
To hide the entire table, click on the "Hide All" button.
You may also shuffle the rows of the table by clicking on the "Shuffle" button.
Or sort by any of the columns using the down arrow next to any column heading.
If you know all the data on any row, you can temporarily remove it by tapping the trash can to the right of the row.
To hide a column, click on the column name.
To hide the entire table, click on the "Hide All" button.
You may also shuffle the rows of the table by clicking on the "Shuffle" button.
Or sort by any of the columns using the down arrow next to any column heading.
If you know all the data on any row, you can temporarily remove it by tapping the trash can to the right of the row.
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.
Normal Size Small Size show me how
Normal Size Small Size show me how
Created by:
thamrick800
Popular Medical sets