Salivary Gland Tumors
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| Major Salivary Glands = ? | * Parotid, Submandibular, and Sublingual
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| Minor = ? | * scattered 500-700 in upper aerodigestive tract
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| The Parotid Gland basics ? | * largest gland..... * Facial nerve divides the two lobes, superficial (80%) and deep (20%)..... * Composed almost entirely of serous acinar cells with striated ducts ...... * superficial lobe = most common neoplasm place
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| Submandibular gland basics ? | * Composed of both mucous and serous secretory cells, so see dark and light staining cells....... * 2nd largest gland
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| Sublingual Gland basics ? | *smallest, and produces only mucous..... *
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| Salivary Gland Tumor Basics ? | * Happen more often in the Parotid Gland (benign usu.).... * Sublingual tumors are the least, but when there is one there, it is almost always Malignant
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| Benign Tumors = ? | * Pleomorphic Adenoma -- Warthin Tumor
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| Malignant Tumors = ? | * Mucoepidermoid Carcinoma -- Adenocarcinoma (NOS) -- Acinic Cell Carcinoma
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| Pleomorphic Adenoma basics ? | * benign MIXED tumor, usu in Paortid gland.... * exhibits both epithelial (ductal and nonductal) and mesenchymal (chondroid myxoid and osseous)
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| Pleomorphic Adenoma Histo? | * See well-demarcated tumor with adjacent normal salivary gland parenchyma and also see
epithelial cells and myoepithelial cells within a chondroid matrix bc it is mixed...... *
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| Pleomorphic Adenoma CxSx ? | * Painless, slow grower, and mobile mass ..... * Can reoccur if you miss a piece of it.... * The longer it is there, the higher chance it turns Malignant --> Carcinoma ex pleomorphic adenoma , which is aggressive
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| Warthin Tumor (Papillary Cystadenoma Lymphomatosum) basics ? | * usu. in Parotid Gland, Older Men, and getting one increases with smoking...... * arise from inclusion of salivary tissue and lymphoid tissue
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| Warthin Tumor Histo ? | * Gross - see we cyctic, well encapsulated mass..... * Histo: see epi. with lymphoid elements.... * Double layer of lining cells:; surface palisade of columnar cells with abundant, finely granular, Eo cytoplasm
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| Mucoepidermoid Carcinoma basics ? | * Most common form of primary malignant tumor of the salivary glands..... * T(11;19)(q21;p13) creates a fusion gene of MECT1 and MAML2 genes, to get high cellular prolif.
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| Mucoepidermoid Carcinoma Cx Features ? | * can grow very large (8cm), no capsule, and if high grade tumor = higher recurrence rate and higher mortality rates
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| Mucoepidermoid carcinoma Histo ? | * Mucicarmine stains the mucin pink-red
...... * Cords, sheets or cystic configurations
Of squamous, mucus or intermediate cells
The intermediate cell ectypes have squamous
features with mucus filled vacuoles
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| Adenoid Cystic Carcinoma basics ? | * very uncommon and rare tumor, that invades nerves = CAUSE PAIN....* slow grower, and has HIGH RECURRENCE rates.... * Can Mets after removal yrs after.... * Very LOW survival rates
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| Adenoid Cystic Carcinoma Histo ? | *see lots of glands, cribriform pattern, Spaces between the cells
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| Acinic Cell Carcinoma basics ? | * Composed of cells resembling normal serous acinar cells of salivary glands, and arise mostly in Parotid gland..... * Very RARE to reoccur if resected.... * HIGH survival rate also
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