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Exam 14: HIV/AIDS

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Term
Definition
Acute Retroviral Syndrome   Viral replication occurs during the acute infection period. Seroconversion is the development of antibodies from HIV. These symptoms may last approximately 1 to 2 weeks (sometimes several months).  
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HIV: early infection   (1) The median time between HIV infection and the development of end-stage HIV disease or AIDS in an untreated individual this is anywhere from 10 to 14 years. Asymptomatic.  
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HIV: Early Symptomatic Disease   CD4+ cell count drops below 500 cells/mm3. Idiopathic fevers, night sweats, chronic diarrhea, HA & fatigue. physical exam may reveal persistent generalized lymphadenopathy (PGL).  
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AIDS   end-stage, or terminal phase, of the spectrum of HIV infection.  
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AIDS: Criteria for diagnosis   As HIV progresses, the CD4+ lymphocytes cell count decreases and the ratio of CD4+ to CD8+ cells (T-helper to T-suppressor cells), normally 2 to 1, gradually shifts resulting in more T-suppressor cells.  
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HIV-1   More rapid onset  
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HIV-2   Slower onset.  
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AIDS (Infected person's CD4+ Count)   cell count of < to 200 cells/mm3.  
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HIV: modes of transportation   Unsafe sexual practice. Sharing needles (sharps). Blood transfusion. Vertical transmission.  
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HIV: The three most common modes of transmission are   (1) Anal or vaginal intercourse. (2) Contaminated drug-injecting equipment. (3) Transmission from mother to child.  
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Opportunistic Diseases associated with AIDS: Respiratory   Pneumocystis jiroveci pneumonia (PCP), fever, night sweats, non-productive cough, progressive shortness of breath, pneumonia, malaise, vesicular eruptions on the tracheobronchial mucosa, chest pain, hemoptysis.  
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Opportunistic Diseases associated with AIDS: Integumentary   vesicular eruptions on mouth and perianal area, shingles, Kaposi’s sarcoma, erythematous papules and nodules.  
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Opportunistic Diseases associated with AIDS: Eye   Lesions of the retina, blurred vision, loss of vision, ocular and/or corneal lesions, visual field defects.  
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Opportunistic Diseases associated with AIDS: Gastrointestinal   watery diarrhea, abdominal pain, weight loss, nausea, stomatitis, esophagitis, gastritis, colitis, bloody diarrhea, whitish-yellow patches in mouth, esophagus and GI tract.  
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Opportunistic Diseases associated with AIDS: Neurologic   cognitive dysfunction, motor impairment, fever, headache, seizures, decrease LOC, hemiparesis, mental and motor declines with progressive multifocal leukoencephalopathy, stiff neck, personality changes, aphasia.  
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HIV disease: Pathophysiology   Requires cells for replication. Released into lymphatic system (binds to CD4+lymphocytes). Reproduces quickly.  
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Diagnostic tests for HIV   ELISA or enzyme immunoassay (EIA), antibody tests that detect the presence of HIV antibodies. CD4+ cell monitoring. Viral load monitoring.  
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CD4+ cell monitoring   Tracks progression of HIV disease. Its the best marker for immunodeficiency with HIV. Used in making decisions about drug therapy.  
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