Medical Cell Biology
Quiz yourself by thinking what should be in
each of the black spaces below before clicking
on it to display the answer.
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| Components/character of a cell membrane | show 🗑
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| show | Phosphotidylcholine, phosphotidylserine, phosphotidylethanolamine, phosphotidylinositol, and sphingomyelin
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| Membrane lipids found in the outer leaflet | show 🗑
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| Membrane lipids found in the inner leaflet | show 🗑
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| Which membrane lipid should never be in the outer leafleat | show 🗑
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| Glycolipids | show 🗑
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| show | Help maintain structural integrity of plasma membrane at extrem temperature. Less cholesterol = more fluidity. More cholesterol = more rigid.
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| show | Remodelling or repairing damage from endocytosis, exocytosis, oxidative damage, ROS attacking polyunsaturated fatty acids.
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| Phospholipase A2 (PLA2) | show 🗑
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| PLA2 in arachidonic acid hydrolysis | show 🗑
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| show | aspirin
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| show | PLC generates DAG for signal transduction. GPCR can activate PLC which then leads to the production of DAG and IP3
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| Flippase | show 🗑
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| show | ATP independent. Ca+2 activated. Always flip things from inside to outside. Brings PS on the outer surface
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| What is the consequence of a non functioning Ca+2 ATpase | show 🗑
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| show | minimal PS exposure
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| show | Exposure of PS on outer surface
In case of sickle cell anemia, PS should not be on the outer leaflet. This causes cells to stick together
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| show | Region of cell membrane where lipids and proteins enriched. Decreased membrane cholesterol leads to melting of lipid raft
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| Lipids | show 🗑
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| show | Integral membrane proteins don't flip flop. They can either be single pass or multipass
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| show | Membrane spanning region: hydrophobic. Regions in cytosol and outside cell: hydrophilic. Example glycophorin A
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| Multi-pass integral membrane proteins | show 🗑
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| Peripheral Membrane Protein | show 🗑
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| Diffusion | show 🗑
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| show | Water movement (hyperosmotic, hypoosmotic, iso-osmotic)
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| show | Used for transport of water, leading cause of cataract in children, Integral membrane proteins, Defects can lead to nephrogenic diabetes insipidus, congenital cataracts in children
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| Donnan Effect | show 🗑
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| show | Na+/K+ATpase by pumping out 3 Na+ ions and take 2K+
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| show | Facilitated transport is required when molecules are too large.
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| GLUT | show 🗑
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| show | Primary and Secondary Active transport
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| Primary active transport | show 🗑
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| show | Movement of molecule 1 across a membrane using free energy derived from transport of molecules 2 down the electrochemical gradient; co-transport
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| Primary Active Transport | show 🗑
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| Ouabain and digitalis | show 🗑
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| show | Same direction. Example Na/Glucose (or amino acid)
symport (SGLT)
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| show | Opposite direction. Example: Na/Ca
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| CFTR defect | show 🗑
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