Medical Cell Biology
Quiz yourself by thinking what should be in
each of the black spaces below before clicking
on it to display the answer.
Help!
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| show | Phospholipid bilayer, cholesterol, proteins. Asymmetric
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| Membrane lipids | show 🗑
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| show | Phosphotidylcholine and sphingomyelin
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| Membrane lipids found in the inner leaflet | show 🗑
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| Which membrane lipid should never be in the outer leafleat | show 🗑
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| Glycolipids | show 🗑
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| show | Help maintain structural integrity of plasma membrane at extrem temperature. Less cholesterol = more fluidity. More cholesterol = more rigid.
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| Lipid Turnover | show 🗑
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| Phospholipase A2 (PLA2) | show 🗑
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| show | PLA2 hydrolysis phospholipids --> arachidonic acid. 1) Arachidonic acid --> 5-lipoxygenase --> Leukotrienes 2) Arachidonic acid --> cycloxygenase --> PGH2 --> Prostaglandins and thromboxanes
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| What inhibits the COX enzyme? | show 🗑
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| Phospholipase C | show 🗑
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| Flippase | show 🗑
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| Scramblase | show 🗑
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| What is the consequence of a non functioning Ca+2 ATpase | show 🗑
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| Active scramblase + Flippase | show 🗑
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| show | Exposure of PS on outer surface
In case of sickle cell anemia, PS should not be on the outer leaflet. This causes cells to stick together
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| Lipid Raft | show 🗑
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| show | Cholesterol, sphingolipids, sphingomyelin and glycolipids
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| Integral Membrane Proteins | show 🗑
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| show | Membrane spanning region: hydrophobic. Regions in cytosol and outside cell: hydrophilic. Example glycophorin A
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| show | Includes transporters, ion channels. Membrane spanning regions may include polar or charged amino acids. Example Band 3
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| Peripheral Membrane Protein | show 🗑
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| show | Small, hydrophobic or hydrophilic molecules can diffuse through membrane according to their concentration gradient (N2, O2, EtOH, Urea)
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| show | Water movement (hyperosmotic, hypoosmotic, iso-osmotic)
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| Aquaporins | show 🗑
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| show | The presence of large molecules on one side balances the greater concentration of a certain ion on the other side. Na+ moves in, water follows, cell burst.
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| How is the Donnan Effect balanced? | show 🗑
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| Facilitated Transport | show 🗑
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| show | Facilitated transporter. Used for glucose transport.Pri
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| show | Primary and Secondary Active transport
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| Primary active transport | show 🗑
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| Secondary active transport | show 🗑
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| show | Na/K ATPase. Transport 3 Na+ ions out of cell and 2 K+ ions into cell uses 1 ATP.
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| Ouabain and digitalis | show 🗑
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| Symport | show 🗑
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| show | Opposite direction. Example: Na/Ca
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| CFTR defect | show 🗑
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