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Medical Cell Biology

Quiz yourself by thinking what should be in each of the black spaces below before clicking on it to display the answer.
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Term
Definition
show Phospholipid bilayer, cholesterol, proteins. Asymmetric  
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Membrane lipids   show
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show Phosphotidylcholine and sphingomyelin  
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Membrane lipids found in the inner leaflet   show
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Which membrane lipid should never be in the outer leafleat   show
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Glycolipids   show
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show Help maintain structural integrity of plasma membrane at extrem temperature. Less cholesterol = more fluidity. More cholesterol = more rigid.  
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Lipid Turnover   show
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Phospholipase A2 (PLA2)   show
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show PLA2 hydrolysis phospholipids --> arachidonic acid. 1) Arachidonic acid --> 5-lipoxygenase --> Leukotrienes 2) Arachidonic acid --> cycloxygenase --> PGH2 --> Prostaglandins and thromboxanes  
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What inhibits the COX enzyme?   show
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Phospholipase C   show
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Flippase   show
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Scramblase   show
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What is the consequence of a non functioning Ca+2 ATpase   show
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Active scramblase + Flippase   show
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show Exposure of PS on outer surface In case of sickle cell anemia, PS should not be on the outer leaflet. This causes cells to stick together  
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Lipid Raft   show
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show Cholesterol, sphingolipids, sphingomyelin and glycolipids  
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Integral Membrane Proteins   show
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show Membrane spanning region: hydrophobic. Regions in cytosol and outside cell: hydrophilic. Example glycophorin A  
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show Includes transporters, ion channels. Membrane spanning regions may include polar or charged amino acids. Example Band 3  
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Peripheral Membrane Protein   show
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show Small, hydrophobic or hydrophilic molecules can diffuse through membrane according to their concentration gradient (N2, O2, EtOH, Urea)  
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show Water movement (hyperosmotic, hypoosmotic, iso-osmotic)  
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Aquaporins   show
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show The presence of large molecules on one side balances the greater concentration of a certain ion on the other side. Na+ moves in, water follows, cell burst.  
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How is the Donnan Effect balanced?   show
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Facilitated Transport   show
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show Facilitated transporter. Used for glucose transport.Pri  
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show Primary and Secondary Active transport  
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Primary active transport   show
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Secondary active transport   show
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show Na/K ATPase. Transport 3 Na+ ions out of cell and 2 K+ ions into cell uses 1 ATP.  
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Ouabain and digitalis   show
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Symport   show
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show Opposite direction. Example: Na/Ca  
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CFTR defect   show
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