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Clinical Signs and Symptoms of GI and Respiratory Pathology

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Sign/Symptom
Pathology
Cough of recent origin   Common cold, rhinitis, acute bronchitis, exacerbation of chronic bronchitis or pneumonia (especially if associated with fever)  
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Chronic cough   Asthma (+/- wheezing), COPD, bronchiectasis, cardiac failure, dry in oesophageal reflux and ACE inhibitors.  
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Cough with postnasal drip or headaches   Upper airway cough syndrome  
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Chronic cough with large amounts of purulent sputum   Bronchiectasis  
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Cough that is worse in the morning   COPD  
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Cough that is worse at night   Asthma  
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Small amounts of blood with sputum   Bronchitis  
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Frank blood, history of smoking, hoarseness   Bronchial carcinoma  
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Dyspnoea with wheeze   Aiway obstruction (COPD or asthma).  
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Dyspnoea of sudden onset   Pneumothorax  
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Asterixis   Respiratory: Severe COPD (CO2 retention) GIT: Early stage of chronic liver failure  
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Central cyanosis   COPD, pulmonary embolism, pneumonia  
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Stridor   Anaphylaxis, acute epiglottitis, inhaled foreign body, tumour  
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Clubbing   Respiratory Tract: Lung carcinoma, bronchiectasis, cystic fibrosis, asbestosis. GIT: Cirrhosis, inflammatory bowel disease, coeliac disease  
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Wasting of interosseous muscles and weakness of abduction   Compression of T1 nerve root (apical lung carcinoma)  
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Pulsus paradoxus and tachycardia   Severe asthma  
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Hypertrophic osteoarthropathy   Associated with clubbing - Lung carcinomas and pleural fibromas  
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Nasal polyps   Asthma  
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Engorged turbinates   Allergic conditions  
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Poor dentition   respiratory: Lung abscess, pneumonia GI: Fetor, ulcers  
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Plethora or cyanosis   SVC obstruction  
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Displacement of trachea towards affected side   Upper lobe fibrosis, atelectasis, pneumothorax  
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Displacement of trachea away from affected side   Massive pleural effusion, tension pneumothorax  
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Barrel chest   Severe asthma or emphysema (gas trapping)  
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Pigeon chest   Manifestation of chronic childhood respiratory illness (RSV)  
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Funnel chest   Developmental defect  
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Harrison's sulcus   Severe childhood asthma or rickets (vitamin D deficiency)  
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Kyphocoliosis   Poliomyelitis, Marfan's syndrome  
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Subcutaneous emphysema   Pneumothorax, rupture of oesophagus  
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Reduced chest wall expansion on one side   Lung fibrosis, consolidation, collpase, pleural effusion, pneumothorax  
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Bilateral reduction of chest wall expansion   COPD, diffuse interstitial lung disease  
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Paradoxical movement of chest   Diaphragmatic paralysis  
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Hoover's sign   COPD  
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Increased vocal resonance, fremitus and whispering pectoriloquy   Consolidation  
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Stony dull percussion   Pleural effusion  
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Hyper-resonant percussion   Bowel, pneumothorax, tension pneumothorax  
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Dull percussion   Consolidation, collapsed lung, liver (upper level of dullness at the 5th rib)  
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Bronchial breath sounds   Consolidation  
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Reduction of breath sounds   COPD (especially emphysema), pleural effusion, pneumothorax, pneumonia, large neoplasm and pulmonary collapse  
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High pitched wheezes   Asthma  
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Low-pitched wheezes   COPD  
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Localised, monophonic wheeze   Fixed bronchial obstruction (carcinoma of the lung)  
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Early-inspiratory crackles   COPD  
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Late-inspiratory crackles   Disease confined to alveoli eg. asbestosis  
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Coarse crackles   Bronchiectasis  
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Pleural friction rub   Pleurisy, pneumonia  
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Liver ptosis   Emphysema  
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Facial plethora, cyanosis,inspiratory stridor, elevated JVP   Positive Pemberton's sign - SVC obstruction  
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Peripheral oedema or cyanosis   Cor pulmonale  
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Reduced FEV1 and FVC with FEV1 being disproporitonately low. Reduced FEV1/FVC ratio   Obstructive ventilatory defect  
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Reduced FEV1 and FVC but increased or normal FEV1/FVC ratio   Restrictive ventilatory defect  
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Dull, burning pain in epigastrium that is relieved by foods or antacids. May wake the patient from sleep   Peptic ulcer disease  
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Steady epigastric pain that radiates to the back. Relieved by sitting forwards   Pancreatic pain  
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Severe, constant pain in the epigastrium that shift the right subcostal region.   Cholecystitis  
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Colicky pain in the renal angle that radiates to the groin.   Renal colic  
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Colicky pain with vomiting, constipation and abdominal distension   Bowel obstruction  
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Anorexia and weight loss   Malignancy, depression.  
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Weight loss and increased appetite   Thyrotoxicosis  
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Disturbance of taste   Liver disease  
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Early satiation   Peptic ulcer disease  
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Acute nausea   GIT infections, small bowel obstruction  
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Chronic nausea   Pregnancy, opiates, chemotherapy, alcoholism, gastric outlet obstruction, acute hepatobiliary disease  
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Heartburn and acid regurgitation   GORD, sliding hiatus herniation  
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Dysphagia for solids only   Mechanical obstruction - carcinoma, foreign body, mediastinal tumours  
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Dysphagia for solids and liquids   Neuromuscular - achalasia (progressive), diffuse oesophageal spasms  
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Odynophagia   Infective oesophagitis, peptic ulceration of oesophagus or oesophageal perforation  
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Constipation   Old age, bowel obstruction, codeine, hypothyroidism, pregnancy  
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Passage of mucus   Solitary rectal uler, fistula, IBS, villous adenoma  
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Haematemesis   Gastric ulcers, oesophageal varices, Mallory-Weiss tear (huge due to coughing or vomiting)  
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Maelena   Bleeding from oesophagus, duodenum or stomach, chronic peptic ulceration, right sided colonic bleeding.  
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Haemaochezia   Haemorrhoids, anal fissures  
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Pruritis   Cholestatic liver disease  
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Jaundice, painlessly distended gall bladder   Carcinoma of the head of the pancreas - Courvoiser's Sign  
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Freckle like spots around the mouth and in the oral mucosa   Peutz-Jeghers Syndrome - associated with hamartomatous polyps in colon  
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Generalised skin pigmentation   Haemochromatosis  
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Brown-black velvety elevtaions of the epidermis of the axilla.   Acanthosis nigricans - associated with GI carcinoma  
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Impaired mental state   Hepatic encephalopathy  
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Leuconychia   Hypoalbuminaemia - chronic liver or renal failure.  
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Palmar erythema   Chronic liver disease, pregnancy, thyrotoxicosis, rheumatoid arthritis  
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Pallor or palmar creases and/or conjunctiva   Anaemia - GI blood bloss, malabsorption (folate or B12) or haemolysis (hypersplenism)  
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Ecchymoses   Clotting abnormalities, obstructive jaundice  
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Petechiae   Chronic excessive alcohol consumption, splenomegaly caused by portal hypertension  
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Spider naevi   Cirrhosis, viral hepatitis, pregnancy  
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Yellow sclera   Hyperbilirubinaemia  
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Kayse-Fleisher rings   Wilson's disease  
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Xanthelasma   Hypercholesterolaemia  
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Bilateral parotid enlargement   Alcoholism  
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Unilateral parotid enlargement   Parotid carcinoma, mumps  
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Fetor hepaticus   Severe hepatocellular disease, precomatose condition  
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Leucoplakia   Poor dental hygiene, smoking, alcohol, sepsis, syphilis  
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Glossitis   Deficiences of folate, B12, alcoholism  
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Apthous ulceration   Crohn's disease, Coeliac disease  
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Angular stomatis (cracks at the corners of the mouth)   Deficiences of vitamin B6, B12, folate or iron  
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Candidiasis   Broad spectrum antibiotics, faulty oral hygeinei, iron deficiency, diabetes mellitus  
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Enlarged left supraclavicular node (Virchow's node)   Gastric cancer  
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Gynaecomastia and hair loss   Chronic liver failure, cirrhosis, alcoholism  
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Bulging region of abdomen when patient coughs   Herniation  
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Abdominal distension   Food, faeces, foetus, flatus, tumour or phantom pregnancy  
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Prominent veins - Caput Medusae   Portal hypertension or IVC obstruction  
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Visible peristalsis   Pyloric obstruction  
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Bluish tinge to umbilicus   Cullen's sign - acute haemorrhagic pancreatitis or severe haemaperitoneum  
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Striae   Cushing's syndrome, pregnancy, ascites  
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Guarding, rigidity, rebound tenderness, cross tenderness, pain on coughing, pain on straight leg raising   Peritonitis  
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Murphy's sign   Cholecystitis  
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Hepatomegaly   Metastases, alcoholic liver disease, right heart falure, hepatocellular cancer, haemochromatosis, bilairy obstruction, hepatitis  
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Epigastric pain   Myocardial infarction, peptic ulcer, pancreatitis, biliary colic  
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Left upper quadrant pain   Spleen, renal colic, diverticulitis  
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Periumbilical pain   Irritable bowel disease, ischaemic bowel disease, ruptured AAA, appendicits, gastroenteritis  
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Left lower quadrant pain   Ovarian, ruptured ectopic pregnancy  
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Right lower quadrant pain   Ovarian, appendicitis, ruptured ectopic pregnancy  
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Right upper quadrant pain   Biliary colic, hepatitis, renal colic, diverticulitis  
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Hepatosplenomegaly   Portal hypertension with chronic liver disease, acute viral hepatitis, sarcoidosis, leukaemia  
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Enlarged kidneys   Renal cell carcinoma, polycystic kidney disease, infiltrative disease  
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Palpable, distended bladder   Urinary retention  
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Arterial pulsations > 5cm apart   AAA  
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Dullness on inspiration of spleen   Splenomegaly  
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Suprapubic dullness   Enlarged bladder or pelvic mass  
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Dull percussion of flanks which becomes resonant when patient rolled onto one side   Acites -shifting dullness  
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Loss of liver dullness   Massive hepatic necrosis, perforated bowel  
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High pitched 'tinkling' bowel sounds   Bowel obstruction  
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Absent bowel sounds over 4 minutes   Paralytic ileus  
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Borboryogmi   Diarrhoea  
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Hepatic friction rub   Tumour within the liver, liver abscess, recent liver biopsy, liver infarct  
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Splenic friction rub   Splenic infarct  
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Venous hum   Intrahepatic portal hypertension  
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Renal artery bruits   Renal artery stenosis  
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Steatorrhoea   Malabsorption of fat, severe pancreatic disease  
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Colorectal cancer (rectum)   Fresh blood with faeces  
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Colorectal cancer (left colon)   Tenesmus, faecal urgency, constipation, rectal bleeding  
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Colorectal cancer (right colon)   Usually asymptomatic until systemic features (weight loss, anaemia, fatgiue)  
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Abdominal fullness, vomiting, problems with absorption and digestion in diabetic patients   Gastroparesis due to neuropathy  
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Intermittent dysphagia, regurgitation, a sense of food being stuck in the oesophagus and chest pain   Achalasia (aperistalsis)  
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