USMLE classical findings & associations
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| Actinic keratosis | Precedes squamous cell carcinoma
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| Addison's disease | Primary adrenocortical deficiency
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| Albright's syndrome | Polyostotic fibrous dysplasia- precocious puberty- café-au-lait spots- short stature- young girls
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| Albuminocytologic dissociation | Guillain-Barre - Increased protein in CSF with only modest increase in cell count
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| Alport's syndrome | Hereditary nephritis with nerve deafness
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| Anti-basement membrane Ab | Goodpasture's
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| Anti-centromere Ab | Scleroderma (CREST)
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| Anti-dsDNA Ab (aka ANA Ab) | SLE - Type III hypersensitivity
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| Anti-epithelial cell Ab | Pemphigus vulgaris
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| Anti-gliadin Ab | Celiac
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| Anti-histone Ab | Drug-induced SLE
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| Anti-IgG Ab | RA
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| Anti-mitochondrial Ab | Primary biliary cirrhosis
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| Anti-neutrophil Ab | Vasculitis
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| Anti-platelet Ab | ITP
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| Arachnodactyly | Marfan's
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| Argyll Robertson pupil | Tertiary syphilis (Prostitute pupil) - accomodates but does not react
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| Arnold-Chiari malformation | Cerebellar tonsillar herniation
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| Aschoff bodies | Rheumatic fever
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| Atrophy of the mamillary bodies | Wernicke's encephalopathy
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| Auer rods | AML - Promyelocytic
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| Autosplenectomy | Sickle cell
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| Babinski's sign | UMN lesion
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| Baker's cyst in popliteal fossa | Rheumatoid arthritis
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| "Bamboo spine" on x-ray | Ankylosing spondylitis
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| Bartter's syndrome | Hyperreninemia
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| Basophilic stippling of RBCs | Lead poisoning
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| Becker's muscular dystrophy | Defective dystrophin
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| Becker's muscular dystrophy | Less than Duchenne's
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| Bell's palsy | LMN CN VII palsy
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| Bence-Jones proteins | Multiple myeloma- Waldenstrom's macroglobulinemia - MM = kappa or lambda Ig light chains; WM = IgM
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| Berger's disease | IgA nephropathy
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| Bernard-Soulier disease | Platelet adhesion defect
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| Bilateral hilar adenopathy + uveitis | Sarcoid
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| Birbeck granules on EM | Langerhan's cell histiocytosis (Histiocytosis X) - Tennis racquets
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| Birbeck granules on EM (diseases) | Eosinophilic granuloma- Hand-Schuller-Christian Disease- Letterer-Siwe disease
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| Bloody tap on lumbar puncture | Subarachnoid hemorrhage
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| "Blue bloater" | Chronic bronchitis
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| Blue-domed cysts | Fibrocystic change of the breast
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| Blue sclera | Osteogenesis imperfecta
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| Boot-shaped heart on X-ray | RVH- Tet
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| Bouchard's nodes | Osteoarthritis - PIP
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| Boutonniere deformity | RA
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| Branching rods in oral infection | Actinomyces israelii
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| "Brown tumor" of bone | Hemorrhage - Due to Hyperparathyroidism- osteitis fibrosa cystica (von Recklinghousen's disease)
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| Bruton's disease | X-linked agammaglobulinemia
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| Budd-Chiari syndrome | Posthepatic venous thrombosis
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| Buerger's disease | Small/medium artery vasculitis
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| Burkitt's lymphoma | 8;14 - EBV
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| Burton's lines | Lead poisoning
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| C-ANCA | Wegener's
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| Café-au-lait spots on skin | Neurofibromatosis
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| Caisson disease | Gas emboli
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| Calf pseudohypertrophy | Duchenne
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| Call-Exner bodies | Granulosa-theca cell tumor of the ovary
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| Cardiomegaly with apical atrophy | Chagas disease
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| Cerebriform nuclei | Mycosis fungoides (Sezary syndrome) - Cutaneous T-Cell lymphoma
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| Chagas disease | Trypanosoma Cruzi
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| Chancre | Primary Syphilis - painless lesion
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| Chancroid | Haemophilus ducreyi - painful lesion
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| Charcot's triad | MS--nystagmus- intention tremor- scanning speech; Cholangitis--jaundice- RUQ pain- fever
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| Charcot-Leyden crystals | Bronchial Asthma - Eosinophil membranes
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| Chediak-Higashi disease | Phagocyte deficiency
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| Cherry-red spot on macula | Tay-Sachs- niemann-Pick- central retinal artery occlusion
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| Cheyne-Stokes respirations | Central apnea in CHF and inc. intracranial pressure
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| "Chocolate cysts" | Endometriosis - frequently both ovaries
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| Chronic atrophic gastritis | Gastric carcinoma
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| Chvostek's sign | Hypocalcemia - facial muscle spasm upon tapping
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| Clear cell adenocarcinoma of the vagina | DES exposure in utero
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| Clue cells | Gardnerella vaginitis
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| Codman's triangle on x-ray | Osteosarcoma
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| Cold agglutinins | Mycoplasma pneumoniae; Mono
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| Cold intolerance | Hypothyroidism
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| Condylomata lata | Secondary syphilis - infectious pink or grey patches on skin
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| Continuous machinery murmur | PDA
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| Cori's disease | Debranching enzyme deficiency
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| Cotton-wool spots | Chronic HTN
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| Cough- conjuncitivitis- coryza- & fever | Measles
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| Councilman bodies | Hepatitis - toxic or viral
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| Cowdry type A bodies | Herpesvirus
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| Crescents in Bowman's capsule | Goodpasture
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| Crigler-Najjar syndrome | Congenital unconjugated hyperbilirubinemia
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| Curling's ulcer | Acute gastric ulcer associated with severe burns
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| Currant-jelly sputum | Klebsiella
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| Curschmann's spirals | Bronchial asthma - whorled mucus plugs
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| Cushing's ulcer | Acute gastric ulcer associated with CNS injury
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| D-Dimer | DIC
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| Depigmentation of neurons in substantia nigra | Parkinson's - basal ganglia disorder - rigidity/resting tremor/bradykinesia
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| Dermatitis- demetia- diarrhea | Pellagra - Niacin (B# deficiency)
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| Diabetes Insipidus + exophthalmos + skull lesions | Hand-Schuller-Christian disease
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| Dog or cat bite | Pasteurella multocida
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| Donovan bodies | Granuloma inguinale
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| Dressler's syndrome | Post-MI fibrinous pericarditis
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| Dubin-Johnson syndrome | Congenital conjugated hyperbilirubinemia - black liver
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| Duchenne's muscular dystrophy | Deleted dystrophin gene - X-linked recessive
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| Eburnation | Osteoarthritis - bones become dense and polished (resembling ivory)
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| Edwards' syndrome | Trisomy 18 (rocker-bottom feet - low set ears - heart disease)
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| Eisenmenger's syndrome | Late cyanosis shunt - Reversal of L-->R shunt
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| Elastic skin | Ehlers-Danlos
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| Erythema chronicum migrans | Lyme disease
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| Fanconi's syndrome | Proximal tubular reabsorption defect
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| Fat - female - forty - and fertile | Acute cholecystitis
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| Fatty liver | Alcoholism
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| Ferruginous bodies | Asbestos
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| Gardner's syndrome | Colon polyps with osteomas and soft tissue tumors
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| Gaucher's disease | Glucocerebrosidase deficiency
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| Ghon complex | Primary TB
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| Gilbert's disease | Benign congenital unconjugated hyperbilirubinemia
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| Glanzmann's thrombasthenia | Defect in plt aggregation
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| Goodpasture | Anti-BM
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| Gower's maneuver | Duchenne's (Pt uses arms to help legs pick self up off floor)
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| Guillain-Barre syndrome | Idiopathic polyneuritis
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| "Hair-on-end" appearance on X-ray | B-thalassemia & sickle cell (Extramedullary hematopoiesis)
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| Hand-Schuler-Christian disease | Chronic progressive histiocytosis
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| HbF | Thalassemia major
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| HbS | Sickle cell
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| hCG elevated | Choriocarcinoma- hydatidiform mole
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| Heberden's nodes | Osteoarthritis - DIP
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| Heinz bodies | G6PD deficiency
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| Henoch-Schonlein purpura | Hypersensitivity vasculitis - Assoc with hemorrhagic uticaria and URIs
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| Heterophil Ab | Mono (EBV)
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| High-output cardiac failure (dilated cardiomyopathy) | Wet beriberi (Thiamine B1 deficiency)
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| HLA-B27 | Reiter's syndrome- ankylosing spondylitis
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| HLA-DR3 or HLA-DR4 | DM I
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| Homer-Wright rosettes | Neuroblastoma
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| Honeycomb lung on X-ray | Interstitial fibrosis
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| Horner's syndrome | Ptosis- miosis- anhidrosis
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| Howell-Jolly bodies | Splenectomy
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| Huntington's disease | Caudate degeneration - Auto dominant
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| Hyperphagia + hypersexuality + hyperorality + hyperdocility | Kluver-Bucy sundrome - problem with amygdala
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| Hyperpigmentation of skin | Addison's disease (primary adrenal insufficiency)
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| Hypersegmented neutrophils | Macrocytic anemia
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| HTN + hypokalemia | Conn's syndrome
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| Hypochromic- microcytic anemia | Iron-deficiency anemia- lead poisoning
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| Increased AFP in amniotic fluid/maternal serum | Anencephaly/spina bifida
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| Increased uric acid levels | Gout- Lesch-Nyhan syndrome- myeloproliferative disorders- loop and thiazide diuretics
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| Intussusception | Adenovirus - how? Hyperplasia of peyer's patches
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| Janeway lesions | Endocarditis
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| Jarish-Herxheimer reaction Syphilis - due to overaggressive treatment of an asymptomatic pt --> rapid lysis | (blank)
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| Job's syndrome | Neutrophil chemotaxis abnormality
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| Kaposi's Sarcoma | AIDS in MSM
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| Kartagener's syndrome | Dynein defect
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| Keyser-Fleischer rings | High free copper (decreased ceruloplasmin) - Wilson's disease
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| Keratin pearls | Squamous cell carcinoma
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| Kimmelstiel-Wilson nodules | Diabetic nephropathy
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| Kluver-Bucy syndrome | Bilateral amygdala lesions
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| Koilocytes | HPV
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| Koplik spots | Measles
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| Krukenberg tumor | Gastric adenocarcinoma with ovarian metastases
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| Kussmaul hyperpnea | Diabetic ketoacidosis
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| Lens dislocation + aortic dissection + joint hyperflexibility | Marfan's - Fibrillin gene defect
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| Lesch-Nyhan syndrome | HGPRT - Nucleotide salvage pathway defect
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| Lewy bodies | Parkinson's
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| Libman-Sacks disease | Endocarditis - Assoc with SLE
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| Lines of Zahn | Arterial thrombus
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| Lisch nodules | Neurofibromatosis (von Recklinghausen's disease)
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| Low serum ceruloplasmin | Wilson's disease
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| Lucid interval | Epidural hematoma
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| "Lumpy-bumpy" glomeruli on immunofluorescence | Poststreptococcal glomerulonephritis
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| Lytic bone lesions on X-ray | Multiple Myeloma
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| Mallory bodies | Alcoholic liver disease
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| Mallory-Weiss syndrome | Esophagogastric lacerations
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| McArdle's disease | Muscle phosphorylase deficiency
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| McBurney's sign | Appendicitis
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| MLF syndrome (INO) | MS
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| Monoclonal Ab spike | Multiple Myeloma- MGUS- Waldenstrom's macroglobulinemia - Called "M protein" - IgG and IgA elevated
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| Myxedema | Hypothyroidism
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| Necrotizing vasculitis (lungs) and necrotizing glomerulonephritis | Wegener's and Goodpasture's (hemoptysis and glomerular disease)
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| Needle-shaped- negatively birefringent crystals | Gout
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| Negri bodies | Rabies
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| Nephritis + cataracts + hearing loss | Alport's
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| Neurofibrillary tangles | Alzheimer's
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| Niemann-Pick disease | Sphingomyelinase deficiency
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| No lactation postpartum | Sheehan's syndrome (pit. Infarct)
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| Nutmeg liver | CHF
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| Occupational exposure to asbestos | Malignant mesothelioma
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| "Orphan Annie" nuclei | Papillary carcinoma of the thyroid
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| Osler's nodes | Endocarditis
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| Owl's eye | CMV
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| Painless jaundice | Pancreatic cancer (head)
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| Palpable purpura on legs & buttocks | Henoch-Schonlein purpura
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| P-ANCA | Polyarteritis Nodosa
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| Pancoast's tumor | Superior sulcus tumor (bronchogenic apical tumor) - Horner's syndrome
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| Pannus | Rheumatoid arthritis
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| Parkinson's | Nigrostriatal dopamine depletion
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| Periosteal elevation on X-ray | Pyogenic osteomyelitis
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| Peutz-Jeghers syndrome | Benign polyposis
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| Peyronie's disease | Penile fibrosis
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| Philadelphia chromosome | CML - 9:22- bcr-abl
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| Pick bodies | Pick's disease
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| Pick's disease | Progressive dementia- similar to Alzheimer's
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| "Pink puffer" | Emphysema
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| "Pink puffer" | Centroacinar (smoking)- Panacinar (a-1 antitrypsin def.)
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| Plummer-vinson syndrome | Esophageal webs w/ iron deficiency anemia
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| Podagra | Gout
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| Podagra | Severe pain in MP joint of hallux
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| Podocyte fusion | Minimal change disease
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| Polyneuropathy- cardiac pathology- and edema | Dry beriberi - Thiamine (B1) deficiency
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| Polyneuropathy preceded by GI/Resp infection | Guillain-Barre
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| Pompe's disease | Glucosidase deficiency - Cardiomegaly
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| Port-wine stain | Hemangioma
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| Positive "anterior drawer" sign | ACL injury
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| Pott's disease | Verterbral TB
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| Pseudopalisade tumor cell arrangement | Glioblastoma multiforme
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| Psudorosettes | Ewing's sarcoma
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| Ptosis- miosis- anhidrosis | Horner's syndrome
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| Rash on palms and soles | Secondary syphilis- RMSF
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| Raynaud's syndrome | Recurrent vasospasm in extremities
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| RBC casts in urine | Acute glomerulonephritis
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| Recurrent pulmonary Pseudomonas and S. Aureus infxns | CF
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| Red urine in the morning | Paroxysmal nocturnal hemoglobinuria
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| Reed-Sternberg cells | Hodgkin's
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| Increased Reid index | Chronic bronchitis
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| Reinke crystals | Leydig cell tumor
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| Reiter's syndrome | Urethritis- conjunctivitis- arthritis
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| Renal cell carcinoma + cavernous hemagiomas + adenomas | von Hippel-Lindau disease
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| Renal epithelial casts in urine | Acute toxic/viral nephrosis
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| Rhomboid crystals- positively birefringent | Pseudogout
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| Rib notching | Coarc
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| Roth's spots in retina | Endocarditis
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| Rotor's syndrome | Congenital conjugated hyperbilirubinemia
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| Rouleaux formation | Multiple myeloma
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| Russell bodies | Multiple myeloma
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| S3 | L-->R shunt (VSD- PDA- ASD)- mitral regurg- LV failure (CHF)
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| S4 | Aortic stenosis- hypertrophic subaortic stenosis
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| Schiller-duval bodies | Yolk sac tumor
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| Senile plaques | Alzheimer's
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| Sezary syndrome | Cutaneous T-cell lymphoma
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| Sezary syndrome | Mycosis fungoides
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| Sheehan's syndrome | Postpartum pituitary necrosis
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| Shwartzman reaction | N. meningitidis
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| Signet-ring cells | Gastric carcinoma
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| Simian crease | Down's
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| Sipple's syndrome | MEN type IIa
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| Sjogren's syndrome | Dry eyes- dry mouth- arthritis
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| Skip lesions | Crohn's
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| Slapped cheeks | Erythema infectiosum (fifth disease) -Parvo
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| Smith Ag | SLE
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| Smudge cell | CLL
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| Soap bubble on X-ray | Giant cell tumor of bone
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| Spike and dome on EM | Membranous glomerulonephritis
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| Spitz nevus | Benign juvenile melanoma
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| Splinter hemorrhages in fingernails | Endocarditis
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| Starry-sky pattern | Burkitt's
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| "Strawberry tongue" | Scarlet fever - Strep pyo
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| Streak ovaries | Turner's
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| String sign on X-ray | Crohn's
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| Subepithelial humps on EM | Poststreptococcal glomerulonephritis
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| Suboccipital lymphadenopathy | Rubella
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| Sulfur granules | A. Israelii
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| Swollen gums- bruising- poor wound healing- anemia | Scurvy (ascorbic acid (vit C) deficiency) - Hydroxylation of Pro- Lys in collagen synthesis
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| Systolic ejection murmur (crescendo-decrescendo) | Aortic stenosis
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| t(8;14) | Burkitt's - c-myc
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| t(9;22) | CML - bcr-abl; Philadelphia chromosome
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| t(14;18) | Follicular lymphoma - bcl-2
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| Tabes dorsalis | Tertiary syphilis
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| Tendon xanthomas (clasically achilles) | Familial hypercholesterolemia
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| Thumb sign on lateral X-ray | Epiglottitis - HiB
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| Thyroidization of kidney | Chronic bacterial pyelonephritis
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| Tophi | Gout
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| "Tram-track" appearance on LM | Membranoproliferative glomerulonephritis
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| Trousseau's sign | Visceral cancer- pancreatic adenocarcinoma (migratory thrombophlebitis)- hypocalcemia (carpal spasm)
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| Virchow's node | Left supraclavicular node enlargement from metastatic carcinoma of the stomach
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| Virchow's triad | Due to PE / triad:Blood stasis- endothelial damage- hypercoagulability
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| von Recklinghausen's disease | Neurofibromatosis with café-au-lait spots
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| von Recklinghausen's disease of bone | Osteitis fibrosa cystica - "brown tumor"
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| Wallenberg's syndrome | PICA thrombosis
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| Waterhouse-Friderichsen syndrome | Adrenal hemorrhage associated with meningococcemia
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| Waxy casts | Chronic end-stage renal disease
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| WBC casts in urine | Acute pyelonephritis
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| WBCs in urine | Acute cystitis
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| Wermer's syndrome | MEN type I
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| Whipple's disease | Malabsorption syndrome caused by Tropheryma whippelii
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| Wilson's disease | Hepatolenticular degeneration
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| "Wire loop" appearance on LM | Lupus nephropathy
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| "Worst headache of my life" | Berry aneurysm - assoc with Adult PCKD
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| Xanthochromia (CSF) | Subarachnoid hemorrhage
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| Xerostomia + arthritis + keratocunjunctivitis sicca | Sjogren's
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| Zenker's diverticulum | Upper GI diverticulum
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| Zollinger-Ellison syndrome | Gastrin-secreting tumor
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| Zollinger-Ellison syndrome | Ulcers
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Review the information in the table. When you are ready to quiz yourself you can hide individual columns or the entire table. Then you can click on the empty cells to reveal the answer. Try to recall what will be displayed before clicking the empty cell.
To hide a column, click on the column name.
To hide the entire table, click on the "Hide All" button.
You may also shuffle the rows of the table by clicking on the "Shuffle" button.
Or sort by any of the columns using the down arrow next to any column heading.
If you know all the data on any row, you can temporarily remove it by tapping the trash can to the right of the row.
To hide a column, click on the column name.
To hide the entire table, click on the "Hide All" button.
You may also shuffle the rows of the table by clicking on the "Shuffle" button.
Or sort by any of the columns using the down arrow next to any column heading.
If you know all the data on any row, you can temporarily remove it by tapping the trash can to the right of the row.
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Created by:
milletbrock
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