Diseases of the Myelin
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| show | A disruption of normal myelin causing neurologic disease
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| Definition of dysmyelinating diseases | show 🗑
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| show | Multiple sclerosis
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| What are the clinical forms of MS? | show 🗑
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| Pathologic characteristics of multiple sclerosis plaques | show 🗑
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| show | Relapsing-remitting MS
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| show | Primary progressive MS
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| show | Secondary-progressive MS
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| Common clinical symptoms of relapsing-remitting form of MS | show 🗑
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| What are the type of MS plaques? | show 🗑
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| Histologic characteristics of active MS plaques | show 🗑
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| show | (1)Demyelination with "naked" axons (2)Minimal inflammatory reaction (3)Dense gliosis (4)Periphery of the plaque is hypocellular
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| Histologic characteristics of shadow MS plaques | show 🗑
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| show | (1)Periventricular areas (2)Cortical gray/white matter transition zone (3)Optic nerves, chiasm, tracts (4)Periaqueductal area (5)Cerebellum white matter (6)Cerebellar peduncles (7)Dorsal spinal cord (8)Subpial region of spinal cord (10)Pericentral canal
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| A very aggressive form of MS where the disease progresses rapidly to disability or death. | show 🗑
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| A rare variant of MS characterized by lesions consisting of rings of demyelination alternating with rings of intact myelin. | show 🗑
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| show | High dose steroids
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| show | Interferon Beta (1a and 1b) or Natalizumab.
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| An acute demyelinating disorder characterized by widely scattered small foci of periventricular inflammation and demyelination most frequently associated with antecedent immunization or infection. | show 🗑
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| Most common preceding infections of postinfectious encephalomyelitis | show 🗑
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| Most common preceding vaccinations of postvaccinal encephalomyelitis | show 🗑
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| Biochemical abnormality associated wtih X-linked Adrenoleukodystrophy (ALD) | show 🗑
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| A rare inherited progressive neurologic disease with adrenal insufficiency. | show 🗑
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| The distribution of lesions of X-linked adrenaleukodystrophy | show 🗑
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| show | X-linked adrenaleukodystrophy
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| show | Dysmyelination results from the myelin membrane insability induced by very long chain fatty chain acid (VLCFA) esters while the demyelination is initiated by cyotkines from an inflammatory response.
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| show | (1) very long chain fatty acid esters levels in chorionic villus samples (CVS) (2) needle-like trilaminar bodies in cultured fibroblasts of culture of amniotic fluid cells.
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| show | Bone marrow transplant
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| Treatment options for X-linked adrenoleukodystrophy | show 🗑
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