Pathology of the Liver
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| show | (1) portal veins - venous blood from pancreas, spleen, stomach, small/large intestines (2) hepatic artery - usually supplied by celiac trunk
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| show | Hepatic vein
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| Components of the portal triad | show 🗑
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| Lobule | show 🗑
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| show | Acute hepatitis
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| show | Viral (Hepatitis A, Hepatitis B, Hepatitis C)
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| Inflammation and hepatocyte injury with biochemical or serological evidence of hepatitis for > 6 months | show 🗑
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| Etiology of acute hepatitis | show 🗑
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| (T or F) Hepatitis A is a common etiological agent of chronic hepatitis | show 🗑
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| A common cause of liver disease in the US. Common morphologic findings include: steatosis, hepatocyte necrosis, infiltrates of neutrophils, Mallory hyaline bodies, and sclerosing hyaline necrosis | show 🗑
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| A form of chronic liver disease with morphologic features of steatosis, hepatitis, and firbrosis. A major risk factor is obesity. | show 🗑
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| show | Primary sclerosing cholangitis (PSC)
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| show | Ulcerative colitis
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| show | Alternating strictures and dilatations and beading of intra and extraheptic bile ducts
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| Chronic progressive inflammatory destruction of intrahepatic biliary tract leading to fibrosis and cirrhosis. Primariliy affects middle-aged females. Characterized by the presence of antimitochrondrial antibodies | show 🗑
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| show | (1) Portal chronic inflammatory infiltrate (2) Lymphocyte infiltration of bile duct epithelium (3) Bile duct necrosis and destruction (4) Portal-based non-necrotizing granulomas
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| Chemical agents that are directly toxic to some cellular components of the liver. Causes injury in virtually every exposed individual in a dose-related manner | show 🗑
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| Chemical agents with unpredictable liver toxicity. Produces liver injury in a small proportion of exposed individuals and does not exhibit a dose-related response | show 🗑
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| show | Cirrhosis
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| (T or F) Portal hypertension is a common finding in end-stage liver disease | show 🗑
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| show | False. Cirrhosis is ettiologically non-specific.
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| show | Focal nodular hyperplasia (FNH)
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| show | Focal nodular hyperplasia (FNH)
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| show | Hepatic adenoma
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| show | Hepatic adenomas have a propensity to hemorrhage which can be fatal.
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| Symptoms include abdominal pain, ascites, and hepatomegaly. Lab tests show elevated alpha-fetoprotein (AFP). | show 🗑
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| show | (1) Cirrhosis (2) hepatotrophic viruses (3) hemochromatosis
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| What is the 5-yr survival of hepatocellular carcinoma? | show 🗑
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| show | False. Morphologic features of hepatocelluar carcinoma is nearly indistinguishable from adenocarinoma metastasis to the liver.
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| A variant of hepatocellular carcinoma found in young patients without cirrhosis. Typically has a better prognosis thatn routine hepatocellular carcinoma | show 🗑
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| show | Bile duct hamartoma (von Meyenburg complex)
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| Benign tumor of the bile ducts. | show 🗑
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| A malignant tumor of hte intrahepatic bile cuts. An adenocarcinoma consisting of duct and gland-like structures lined by cuboidal-to-columnar cells with varying degrees of cytologic atypia. Poor prognosis. | show 🗑
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| show | Hemangioma - a benign vascular tumor of the liver
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| show | Angiosarcoma
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| (T or F) Metastases occur with equal prevalence in both cirrohtic and non-cirrhotic livers | show 🗑
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