Question | Answer |
What is kidneys roll in blood pressure? | Increased bp -> increased diuresis and natriuresis -> Decreased BV |
What is pressure diuresis/natriuresis? | A few mm hg increase -> doubles the effect of renal output. |
What is the two primary determinants of the long-term arterial pressure level? | Shifting the equilibrium point. That is to change the intake/outtake level in ren. |
Decribe the arterial pressure in kidney. | CO and peripheral resistant changes while arterial pressure in ren is constant. |
Define hyper tension. | Blood pressure s>135 d>90 |
Hypertension causes? | 1) heart failure and coronary heart disease 2)increased bp-> cerbral infarkt (stroke) 3) increased bp-> hemorrage in ren |
Hypertension is caused by? | Excessive accumulation of extracellular fluid in the body. |
Describe changes in circulary function during volume-loading hypertension! | 1) increased extracellular fluid volume-> increased blood volume -> increased CO -> increased bp actives baroreceptors-> Vasodilatation -> decreased resistance |
Why does kidney failure cause high pressure? | Kidney can't secrete salt -> hypertension |
Salt causes? | 1) Stimulation of thirst center in medulla. |
What is the salts effect on renin-angiotensin system? | Increased salt intake->Increased ECV-> Increased BP-> Decreased renin & angiotensin-> decreased retention of salt and water-> Return of ECV back to normal-> normal BP |
Why does aldesteronism lead to hypertension? | Tumor or patological disorder in adrenal gland -> increase alderone release-> increased salt&water absorbtion ->hypertension |
Describe the renin-angiotensin system! | dec. bp->prerenin (stored in juxta glomeruler cells) ->renin (func. enzym) -> angiotensin-I (have a little vasoconstrion effect)-> angiotensin-II (lungs) |
What does angiotensin-II (prod. lungs) have for effect? | 1)Vasoconstricter (arteriols and little on veins) 2)retention of water & salt (because of renvasoconstrion and better absorbtion) 3) release of aldorone (causes better absorbtion in ren) |