Question | Answer |
Head trauma, disoriented => lucid => coma | Epidural Hematoma |
Lens shaped hemorrhage | Epidural Hematoma |
Concave shped hemorrhage | Subdural Hematoma |
Unilateral facial weakness w/ inability to close eye | Bell palsy (self-limiting) |
Adolescent female w/ HA. +FHx. Severe HA, N/V, photphobia. +/- auras (usu contra to HA) | Migraine HA |
Male, recurrent relapsing HA. Worsened w/ EtOH, Lacrimation, salivation, rhinorrhea | Cluster HA |
Sudden onset thunderclap HA, "worse HA of my life" | Subarachnoid hemorrhage |
>50 yo female w/ HA. Temporal artery tenderness or blindness | Temporal arteritis (Giant cell arteritis). Elevated ESR, get temporal artery biopsy |
Recurrent episodes of vision change, diplopia, weakness & tingling in extremities that resolve | MS |
HA worse in AM w/ focal neuro deficits | Brain Tumor (MC is glioma) |
s/p Fall w/ bilateral LE weakness, urinary and rectal incontinence, decreased rectal tone | Cauda equine syndrome = neurosurgical consult |
Ascending paralysis | GBS |
Paralysis after Campylobacter enteritis | GBS |
Young kid with difficulty standing from seated position. Calf muscle wasting | Muscular dystrophy (weakness begins at pelvic girdle) |
Pediatric with fever or Hx URI with encephalopathy, emesis, hyperactive reflexes, hepatomegaly, elevated liver enzymes | Reye's syndrome from URI/post-flu or aspirin use |
"Ash leaf" hypopigmentation of trunk & Ext, shagreen patch, sebaceous adenomas, seizures, mental retardation; assoc w/ PCK, renal hemartomas | Tuberous sclerosis (auto dominant) |
Ortho BP defn | drop of 20 (SBP) or 10 (DBP) within 3 min of standing |
fluctuating weakness/fatigability of voluntary mx (diplopia, blurry vision, ptosis, difficulty swallowing); resp difficulty, limb weakness (worsened w/activity); bulbar sxs (dysarthria, dysphagia, fatigable chewing) | Myasthenia gravis |
Light touch: Side of Neck: | C2-3 |
Light touch: Tip of Shoulder: | C4 |
Light touch: Lateral Deltoid: | C5 |
Light touch: Thumb: | C6 |
Light touch: Middle Finger: | C7 |
Light touch: Pinky Finger: | C8 |
Light touch: Medial Forearm at elbow: | T1 |
Light touch: 1st Dorsal web: | Radial nerve |
Light touch: Palmar middle pad: | Median |
Light touch: Palmar small pad: | Ulna |
Light touch: Groin: | L1 |
Light touch: Upper thigh: | L2 |
Light touch: Outer thigh at knee: | L3 |
Light touch: Medial ankle: | L4 |
Light touch: Dorsal 1st web space: | L5 |
Light touch: Lateral ankle: | S1 |
Light touch: Buttock: | L2-3 |
Light touch: Perianal: | L4 |
DTR: Biceps: | C5 |
DTR: Brachioradialis: | C6 |
DTR: Triceps: | C7 |
DTR: Knee: | L 3,4 |
DTR: Ankle: | S1 |
DTR: 0: | absent |
DTR: 1: | diminished |
DTR: 2: | average |
DTR: 3: | exaggerated |
DTR: 4: | clonus |
Ischemic stroke pathophys | atheroembolic (50%); cardioembolic (30%); OR 2/3 thrombotic & 1/3 embolic |
Stroke pathophys | 80% ischemic, 20% hemorrhagic |
Hemorrhagic stroke pathophys | parenchymal ICH (10-15%); subarachnoid (5-10%) |
Most common parenchymal ICH: | Hpertensive intracerebral hemorrhage |
Primary ICH presentation | HA, N/V; progressive hemiparesis & hemisensory def; HTN (on hx and on PE) |
Primary hypertensive ICH: typical locations | Thalamus; Basal Ganglia; Pons; Cerebellum |
ICH presentation: Thalamus/ Basal Ganglia | Contralateral Motor/ Sensory Deficit; Aphasia, Neglect; Depressed LOC with mass effect, IVC extension |
ICH presentation: Cerebellum | Ipsilateral Ataxia; Depressed LOC |
ICH presentation: Pons | Vertigo, Diplopia; Crossed signs; Depressed LOC |
Anterior circulation consists of: | Ant choroidal, ant cerebral, MCA |
Anterior circulation supplies: | Cortex, subcortical white matter, basal ganglia, internal capsule |
Anterior circulation stroke | Hemispheric s/s: aphasia, apraxia, hemiparesis, hemisensory loss, visual field defects |
Posterior circulation consists of: | Verterbral & basilar arteries |
Posterior circulation supplies: | Brain stem, cerebellum, thalamus, parts of temporal & occipital lobes |
Posterior circulation stroke | Sxs of brainstem dysfn: coma, drop attacks, vertigo, N/V, ataxia |
Thrombotic vs embolic stroke sx progression | Thrombotic: stepwise progression, often preceded by TIA; Embolic: abrupt & without warning |
Amyloid angiopathy stroke: patho | Blood vessel degeneration; Dementia; Lobar hemorrhage |
Amyloid angiopathy: presentation | Dementia; Episodic worsening; No h/ o HTN; poss acute limb weakness; BP less severe than in ICH; stroke d/t cerebral microhemorrhages |
Venous infarction presentation | h/o OCP/SMK; HA; aphasia, weakness |
Most common cause of subarachnoid bleed | aneurysm |
Subarachnoid bleed: RF | HTN; SMK; heavy EtOH; genetics (polycystic kidney dz; Ehlers-Danlos; 1st-degree relative) |
SAH stroke presentation | Abrupt severe HA; meningismus; depressed LOC; nonfocal neuro exam; BP rises precipitously; poss temp to 39C |
Atheroembolic stroke characterized by: | Single vascular territory; Warning signs; Stepwise progression |
Atheroembolic stroke presentation | Hx HTN, CAD; transient language disturbance; transient weakness |
Ant cerebral art infarct: likely fx: | contralateral leg (motor > sensory) |
MCA infarct: likely fx: | face/arm more than leg/vision; poss aphasia |
Vertebrobasilar art infarct: fx: | Midbrain: 3d nerve nuclei; ipsilateral ptosis; eye deviated outward (bc CN VI is fine, but III is affected); crossed signs: pt has CNIII probs on one side and sensory probs on opp side of body |
Subcortical infarct effects by body area: | face = arms = legs |
Cortical infarct fx by body area: | gradation btw face, arms, & legs |
Lacunar syndromes | Pure Motor Stroke; Pure Sensory Stroke; Ataxic Hemiparesis; Clumsy Hand Dysarthria |
Cardioembolic stroke presentation | h/o A fib; aphasia; hemiparesis/hemisensory deficit affecting face and arm |
Cardioembolic: dx | Maximal deficit at onset; Multiple vascular territories; Cardioembolic source; Hemorrhagic infarction (Wedge shaped infarct towards cortical surface) |
Cardioembolic: possible etiology | A fib; Cardiomyopathy; Acute MI; Valvular heart dz |
TIA S/S | Acute focal neuro def; S/S resolve within 24 hr; No rad evidence of infarction; Ischemic etiology, usu carotid or vertebral vascular distn |
TIA: risk of subsequent stroke: | 11% risk of stroke within 3 mo; 1/3 of TIAs have stroke within 5 yrs; 63% of strokes occur within the first wk, 85% within first month |
Modifiable RF for first stroke | *HTN*; A fib; carotid stenosis; DM; hyperlipidemia; prior stroke/TIA |
Prevention of A fib RF: | Low risk (0-1) ASA; mod (2) ASA or warfarin (but AE/bleed risks); high risk (>2) warfarin |
Stroke prevention DM pts | glucose ctrl: no fx on stroke/macrovascular comp; tight BP ctrl (<130/80) effective; statins |
TIA carotid: S/S | contralat hand-arm weak & sensory def; ipsilateral visual sx & aphasia or amaurosis fugax; poss carotid bruit (absent in high grade stenosis) |
TIA vertebrobasilar S/S | diplopia, ataxia, vertigo, dysarthria, CN palsies, LE weak, blurred vision, perioral numbness, poss drop attacks |
TIA DDx | Sz, migraine, syncope, hypoglycemia, mass lesion |
SAH etio: aneurysm | nontraumatic: 75% saccular (berry) aneurysm, 50% mort; 5th-6th decade, M=F |
aneurysm RFs | SMK, HTN, high chol; PKD, coarct |
complex partial sz | may have aura, then impaired consciousness |
simple partial sz has no: | impairment of consciousness |
Most common cause of tonic-clonic in pts (onset < 30 yo): | idiopathic epilepsy |
Clonic seizures: | usu in childhood; impaired consciousness, followed by asymmetric bilateral jerking |
Most common seizure type: | complex partial |
complex partial sz: | 10-30 yo; common post-head trauma; 50% abnml CT/MRI; 50% mesial temporal sclerosis; 20% hamartoma |
complex partial sz: etio by age | 30-60 yo: poss brain tumor; >60 yo: more likely stroke |
Status epilepticus dx does not apply to: | continuous simple partial seizures |
EtOH withdrawal seizure: | onset 6-48 hr after last drink; often primary generalized, often have Todd paralysis |
Sz remission: | usu within 3 yrs of first seizure; prolonged remission in 60% of such pts |
Factors against sz remission | FH; psych comorbid; febrile seizure hx; more seizures; age |
Todd paralysis = | post-ictal focal weakness in part of body, confined to L or R, usu arms/legs |
Most common agent of meningitis in adults | S. pneumo |
Meningitis general S/S | HA, fever, neck / back stiffness, neuro impairment |
Meningitis presentation | acute (hrs - days), usu w/ fever, HA, stiff neck, lethargy; usu without focal sx |
Typical purulent meningitis orgs | N. meningitidis, S. pneumoniae, or H. influenzae |
Chronic meningitis: orgs | TB; fungal |
Encephalitis presentation | diffuse infxn; confusion, lethargy, often seizures; CSF may be normal |
N. meningitidis | petechial rash; GN diplococci; often assoc w/DIC |
H flu meningitis: commonly found: | less common in adults; in setting of otitis or sinusitis |
Tuberculous meningitis S/S | usu gradual onset; listlessness & irritability; CN palsies; |
Abscess: common orgs | streptococcus, staphylococcus or anaerobes |
Rabies S/S | (> 10 days) delirium, painful swallowing, rage alternating with calm |
Rabies incubation period | >10 days (usu 3-7 wks) (infected animal dies within 5-7 days) |
Herpes encephalitis: commonly found: | more common in elderly; often medial temporal lobes |
CJD S/S | usu later in life; rapidly progressive dementia, myoclonus, ataxia & somnolence; epileptiform pattern on EEG |
MS S/S | Optic neuritis; Transverse myelitis; Paresthesias; focal neuralgia; Ataxia; Weakness/ incoordination; Spasticity; Cognitive impairment |
Lhermitte's sign = | electrical sensation down body w/ neck flexion; seen in MS |
MS pathophys | immuno d/o assoc w/CNS Ig prodn & T-lymph alteration; poss viral etio |
MS pattern of sxs | affect multiple areas over time (if they don't, prob not MS) |
Anti Epileptic Drugs: titration | Start low & gradually increase; initiate with 1/3-1/4 of anticipated maintenance dose & increase over 3-4 weeks |
when Anti Epileptic Drugs may be dc'd: | If onset btw age 2-35 & normal EEG; seizure-free period 2-4 yrs; complete ctrl within 1 yr; very gradual taper over 6 mos; relapse usu within first few mos after withdrawal; f/u in 5 yrs if no probs |
Majority of malignant gliomas are: | grade IV tumors (GBM or gliosarcomas) |
Gliomas include: | Astro (Grade 1); oligo (2); ependymoma; glial cells |
Grade 3 Glioma = | Anaplastic Astrocytomas, Anaplastic Oligodendrogliomas |
Grade 4 Glioma = | GBM; Gliosarcoma |
Diffuse astrocytomas include: | Low-grade infiltrative Astro (WHO II); anaplastic astro (WHO III); Glioblastoma (WHO IV) |
Circumscribed astrocytomas include: | Pilocytic Astro (WHO grade I); Pleomorphic xanthoastrocytoma (PXA); Subependymal giant cell Astro (SEGA) |
Well-differentiated Astro: | 10-15% of Astros; 35 yo; 5-10 yr surviv; cerebral hemi / cortex; slow growing; often undergo malig progression to AA or GBM |
characteristic of high-grade gliomas (III/IV): | Invasion via white matter tracts, cross via corpus callosum |
Primary characteristic of a grade IV glioma = | necrosis with vascular proliferation |
Anaplastic astro | High-Grade; 1/3 of Astros; 45 yo; 3 yr surviv; usu in cerebral white matter; relatively fast-growing; Frequent progression to GBM |
GBM | usu in cerebral hemi white matter; spreads rapidly & diffusely; Ring of tissue around necrotic core; Highly vascular |
Oligodendroglioma | Usu presents at low-grade (II) stage; young / middle-aged; grade II >10 yr surviv; Fried-egg cells |
Most common primary brain neoplasm = | GBM |
Untreated GBMs: growth | double in size in 14 days |
Brain tumor: genl clin presentation | HA; seizures; Cognitive dysfn; Focal neuro deficits; N/V; Sx endocrine dysfn; Visual sx; Sx from plateau waves (ICP changes) |
Headache in brain tumor | 20% of pts present w/HA (more w/ post fossa tumor); usu d/t inc ICP; Progressive increase in HA freq & severity; Classic HA on waking or HA that wakens one from sleep |
Seizure in brain tumor | 35% of pts present with this; often the sx that precedes dx; focal or secondarily generalized |
Probably most common problem in pts w/brain tumors = | cognitive dysfn (Frontal personality; Memory problem; Depression) |
Cognitive dysfn: Left hemispheric tumors: | language dysfunction |
Cognitive dysfn: Right hemispheric tumors: | problems with visual perception & scanning |
Brain tumor: Focal neurologic deficits | Hemiplegia; Hemiparesis; Ataxia; Nystagmus; Can mimic stroke |
Brain tumor: N/V more common in: | posterior fossa tumors |
Endocrine sxs in brain tumor: | hypothyroid; dec libido |
Visual symptoms in brain tumor include: | Contralateral flashing lights; Visual field loss; Diplopia |
Low grade glioma: Tx | Bx (confirm dx & r/o high grade); seizures only: defer tx til progresses; if progressive sx: resect +/- CTx (+ RTx only if refractory) |
Second leading COD in brain tumor pts: | thromboembolic complications |
Meningioma | slow growing, benign; attached to dura mater; 13-26% of primary IC tumors; RF: prior radiation; often Asx; visual complications; DDx: neurofibromatosis; Firstline tx: Surgery |
Ependymoma: worse prognosis: | <3 yo |
Ependymomas within brain: locations | Infratentorial > supratentorial (2:1) |
Ependymoma | Usu slow growing; kids & YA; young adults; 4% all BT; from walls of ventricles or spinal canal (obstructive hydrocephalus); 90% are in brain, 10% in spinal cord (often adults) |
Characteristics of Medulloblastoma | Malig, invasive embryonal cerebellar tumor; kids & YA; 70-80% 5-yr survival; Most arise in vermis (4th ventricle involvement) |
Medulloblastoma: metastases | Metastasize via CSF pathways (Drop Mets); Rare mets to bone, lymph nodes, other extracranial sites |
Characteristics of Primary CNS lymphomas | Usu present deep in brain parenchyma; usu multifocal (diffuse lg cell B-cell lymphoma); Survival w/o tx <1 yr; Steroid tx & Methotrexate CTx |
most common spinal tumor: | ependymomas; 10% of spinal tumors are intramedullary |
Brain tumor: frontal lobe: S/S: | cog decline; contralat grasp reflex; expressive aphasia |
Brain tumor: temporal lobe: S/S: | sz, olfactory hallucination, depersonalization, vis field def, auditory illusions |
Brain tumor: parietal lobe: S/S: | contralat sensory def; cortical sens loss (stereognosis); inattention |
Brain tumor: occipital lobe: S/S: | crossed homonymous hemianopia / partial field defect; visual agnosia |
Brain tumor: brain stem/cerebellar: S/S: | CN palsies, ataxia, incoordination, nystagmus, pyramidal & sensory def |
Lucid interval seen in what trauma? | epidural hematoma |
subdural hematoma: blood source | usu venous (bridging veins in space) |
subdural hematoma: etiology | Acceleration/ Deceleration injury; Veins transversing subdural space |
Orbital blowout fx | comminuted floor fx: herniated orbital contents; inf rectus mx entrap or vert diplopia d/t edema; blood in max sinus when orbital trauma |
2/3 of all cerebral infarcts are: | MCA stroke |
Lacunar stroke | 15-20% of strokes; small vessel ischemia; HTN; usually pure sensory OR motor |
Astrocytoma | Glial tumors: 40-50% of CNS Neoplasms |
Astrocytoma: Grade IV | GBM (45-55 yo); necrosis/ hemorrhage, edema, ring enhancement |
Meningioma | 50-60 yo; may increase in PG; various grades (90% benign) |
Brain neoplasm: mets | 1/3 of all intracranial neoplasms; lung, breast, melanoma, colon, lymphoma, prostate |
Brain neoplasm: most common site for kids (unlike adults) | posterior fossa (medulloblastoma) |
Argyll Robertson pupil = | pupil reacts to light but does not accommodate (seen in tertiary syphilia/tabes dorsalis) |
NPH (chronic hydrocephalus) S/S: | Incontinence, gait abnormalities, dementia |
Ulnar neuropathy | stretch / compress ulnar n.; cubital tunnel or Guyon canal; d/t pressure, bone spurs, cysts; sensory precede motor sx |
Ulnar neuropathy: provoking factors | Elbow Flexion (Cubital), Wrist Extension (Guyon); Nighttime |
Radial neuropathy: etiology | axilla (crutches); Saturday night palsy; handcuffs; humerus fx |
Radial neuropathy: S/S | Motor>sensory; weakness in extension & arm ext rotation; forearm atrophy; xray shoulder/humerus |
Meralgia paresthetica: S/S | pain, paresthesia, numb; outer thigh; usu unilateral (relieved by sitting); no motor sx |
Fem neuropathy: RF | lithotomy posn (inguinal lig); DM; retroperitoneal neoplasm/hematoma; pelvic fx; fem art cath (n. trauma) |
Fem neuropathy: S/S | Quads atrophy/weakness; sensory impairment anteromedian thigh; decreased patellar DTR; EMG/NCS; CT/MRI |
Sciatic n. palsy: S/S | weakness w/ leg flexion, dorsiflexion & foot eversion (drop foot); hamstring & ankle DTR dec/absent; sensory loss posterior thigh/leg/foot; tingling/burning/lanceting pain (worse w/standing, cough) |
Peroneal n. palsy: S/S | weak dorsiflexion (foot drop) & eversion; sensory loss/ paresthesia: anterolateral calf & foot dorsum |
CN VII palsy (Bell): etiology | idio; HIV, sarcoid, Lyme, tumor; HSV infxn? RF = PG, DM |
CN VII palsy: S/S | abrupt; facial paralysis (some upper sparing); drooping corner of mouth; ptosis/ forehead smooths out; ear pain; dysgeusia; hyperacusis |
CN VII palsy: to distinguish btw peripheral & central lesion: | peripheral: complete paralysis forehead mx; central: partial sparing forehead mx |
CN VII palsy: prognosis | 60% spont resolve; 10% perm disfigurement/dysfn; best indicator of severity = progress first 2-3 days; worst: complete palsy at onset, advanced age, hyperacusis, severe initial pain |
Charcot-Marie-Tooth: genetics | usually auto dom |
Charcot-Marie-Tooth: patho | Type I: demyelinating; II: axonal; Motor>Sensory; Lower > Upper; childhood/young; slow progression |
Charcot-Marie-Tooth: CMT I vs CMT II: S/S | CMT II: less mx wasting/ secondary weakness; less common postural tremor/arm involvement; NO peripheral n. hypertrophy |
Dejerine-Sottas Dz (CMT III): pathophys | phytanic acid disturbance; prog demyelinating neuropathy; infancy/kids |
Dejerine-Sottas Dz: S/S | weakness, ataxia; sensory loss; DTR: global hyporeflexia |
Refsum dz: patho | Progressive demyelinating neuropathy; early childhood |
Refsum dz: S/S | weakness, ataxia; sensory loss; DTR: global hyporeflexia; retinitis pigmentosa; Tx supportive |
Systemic-metabolic neuropathies include: | DM; uremia; alcoholic & nutrition def; paraproteinemias; CTD, amyloidosis |
DM neuropathy | sensory precedes motor; lower ext precedes upper; Hx: autonomic sx?; NCS nml / mildly slow |
Charcot arthropathy | 2/2 Joint Subluxation, Periarticular fx; rocker bottom foot; pain, swelling, ulceration |
Uremia: S/S | Symmetric sensory-motor; lower ext > upper; distal > proximal; severity correlates with degree of renal insufficiency |
Neuropathy: EtOH/ Nutritional deficiency | cobalamin (B12) def; axonal > myelin; slow progression |
EtOH/Nutritional deficiency: S/S | Distal symmetric Polyneuropathy; sensory precedes motor; Lower ext precedes upper; cramps, painful paresthesias, tenderness; CNS Sx often precede PNS; mental status change; myelopathy; optic neuropathy |
AIDP (GBS): patho | Progressive Demyelinating; prob immune-mediated; Axonal Subtypes (AMAN; AMSAN) |
AIDP (GBS): Motor S/S | Ascending weakness; Symmetric; Proximal > Distal mx; Lower ext before Upper; Advanced: Resp mx Compromise, CN Involvement |
AIDP (GBS): Sensory S/S | Pain/paresthesias; Loss of Sensation; Distal before Proximal; DTR: Global hyporeflexia or areflexia; autonomic dysfn: tachycardia, cardiac irreg; BP changes, pulmonary dysfn, loss of rectal tone |
Leprosy: 2 Types: | tuberculoid (multifocal) & lepromatous (symmetrical) |
MG pathophys | Abs vs acetylcholine receptors |
LEMS pathophys: | defective release of Ach in response to nerve impulse; may be assoc with small cell ca |
MG vs LEMS: S/S | LEMS: power increases w/sustained contraction; MG: fatigability |
Ataxic (intention) tremor | Absent at rest/start of movement; dysmetria; Dz of cerebellum / connections (MS; tumors; infarct; ethanol-induced cerebellar degeneration) |
Athetosis = | slow writhing purposeless movements usu involving hands, tongue & face; usu in kids w/ cerebral palsy or result of kernicterus or hypoxia |
Chorea: Sx | Involuntary, irregular jerky movements; can cause continuous movements. |
Chorea: may be due to: | untreated strep infxn (Sydenham chorea), PG (chorea gravidarum) or Huntington dz |
Tics | onset 2-13 yo; tx Haldol/pimozide |
Hemiballismus | Violent flinging movements; Unilateral hemiballismus usu d/t infarct in contralateral subthalamic nucleus of Luys |
Dystonia: | Maintenance of a persistent extreme posture in one or more joints. |
Focal dystonias: | torticollis, writer's cramp, blepharospasm; tx Botox / surg |
Parkinson dz: Sx | Rest tremor/3-6 hz; pill rolling; cogwheeling; rigidity; bradykinesia; difficulty initiating movement; masked facies; stooped posture, shuffling; disturbance of postural reflexes; diminished eye blinking rate |
Parkinson dz: Patho | Degen nigrostriatal pathway, raphe nuclei, locus ceruleus & motor nucleus of vagus; dramatic loss of DA-containing neurons |
Huntington Dz presentation | AD, varying age of onset; Sx often begin w/ psych disorder (immaturity, impulsivity, depression); later apathy & dementia; Chorea, Athetosis; butterfly ventricles (caudate atrophy) |
Huntington chorea due to: | DA excess state |
Wilson dz | Auto rec; onset 2nd-3rd decades; first sx: hepatic dysfn/cirrhosis; tremor/ bradykinesia, dysarthria, dysphagia; limbs rigid, facial mx fixed empty smile; arms: wing-beating tremor; Kayser-Fleischer (deep cornea) |
Wilson: patho | CNS changes: brownish discoloration of some basal ganglia; proliferation of protoplasmic astrocytes (Alzheimer Type II cells) |
Tardive dyskinesia: Sx | Abnormal BLM (tongue thrusting & chewing); head movements (turning & bobbing); poss also abnormal limb movements; Sx can fluctuate & may take mos-yrs to resolve (sometimes permanent) |
Tardive dyskinesia: most successful tx: | achieved with DA-depleting agents (tetrabenazine); also Vitamin E? |
Action of acetylcholine & DA: | Act in opposite directions; adding DA is equivalent to blocking acetylcholine |
Huntington dz genetics | Huntingtin gene is on short arm of chromosome 4; >35 CAG trinucleotide repeats = penetrance/affected/dz |
RLS can be primary, or secondary to: | periph neuropathy, uremia, PG, Fe def |
Migraine dx criteria | ≥2 of: (Unilateral; Pulsating; Mod/ severe intensity; fx: avoidance of routine physical activity); 1 of: (N/V; Photophobia & phonophobia) |
Severe episodic HA with cerebellar sx = | basilar migraine |
Chronic migraine: dx | chronic daily HA ≥3 months; >8 d/mo x 3 mos |
Sinus HA vs migraine | sinus usu continuous (not intermittent); TTP over sinuses; tx w/ Abx |
chronic daily HA | ≥ 15 d/mo; primary or secondary (usu considered primary); ≥1 migraine/wk = RF for dev chronic daily HA |
SUNCT = | Short-lasting; Unilateral; Neuralgiform HA, with Conjunctival injection & Tearing; rare; M>F (>50 yo) |
SUNCT sx | burning, stabbing, throbbing; seconds to 4 min; 5-6 per hr; SBP may rise |
Cluster HA = | M>F (older than migraine); severe, unilateral, nasal congestion, injected conjunctiva, ipsilateral sweating; at night (wakes pt) |
HA red flags (SNOOP) | Systemic sx; secondary RF; neuro sx; onset sudden; older pt; Progression/prior HA hx; Pattern changes |
Sumatriptan: indications | migraine (abortive tx); acute tx cluster HA; Fast onset, short duration; repeat dose in 1 hr if nec; Never give IV or IM |
Ergotamine MOA | direct sm mx vasoconstrictor |
Beta blockers: MOA: | central/serotonergic, beta-1 mediated |
Migraine: prophylaxis | Beta (50-60% efficacy); TCA; SSRIs; bupropion; Valpro; verapamil; NSAIDs (ST for predictable) |
Prophylactic tx: adequate trial of tx: | 6-8 weeks |
Menstrual migraine: Tx | NSAIDs: begin 2-7 days prior to menses, continue through last day of flow; Hormonal therapy (OCP) |
TCA MOA | antagonism of vascular or brainstem 5-HT2 |
concomitant dysphasia, hemianopia, or focal epilepsy is a __ lesion | supratentorial |
brain tumors seldom__ | metastasize outside the CNS |
__ spread the soonest with metastatic brain tumors | lung and renal cancer cells |
mets to the brain in men generally come from __ | lung, colon, and renal cancers |
mets to the brain in women generally come from __ | breast, lung, and melanoma |
epilepsy that has failed two medications is | medically intractable epilepsy |
to reduce risk of damaging language and memory, patients can undergo a __ test before neurosurgery | WADA |
Subarachnoid hemorrhage may block __ causing hydrocephalus | arachnoid villi |
T or F: diplopia, syncope, dizziness, vertigo, and paresthesia are symptoms of carotid disease | false |
Cause of Amurosis Fugax | embolization of retinal arteries |
a tumor in the supratentorial region may result in which pathologic disorder | epilepsy |
which cancers metastasize to the brain the fastest? | lung and renal |
in which area of the brain do most mets tumors arise? | cerebrum 80% |
tethered cord | abnormally low conus medullaris |
Acute subdural hematoma: timeframe | Acute: 0-1 week |
Chronic subdural hematoma: timeframe | >2 weeks |
Most common cause of SAH | Trauma |
Loss of consciousness requires: | Both cerebral hemispheres damaged OR brainstem lesion |
Coma: causes | Cerebral infarction 10%; Cerebral hemorrhage 20%; Metabolic causes 50% (Drug ingestion >50%; Hypoglycemia 5-10%); Psych 2% |
Hollenhorst plaque | cholesterol emboli from carotid |
Decorticate posturing: | hemispheric or diencephalic dysfn d/t destructive lesions or metabolic abnormality; hands come up (response to stimuli) but do not localize |
Decerebrate posturing: | midbrain or upper pons dysfunction on a structural or metabolic basis; wrists flex (response to stimuli), not localizing |
Cheynes-Stokes: | Bilateral hemispheric lesions; most commonly seen in non-neurologic disorders (CHF); crescendo-decrescendo |
Central neurogenic hyperventilation is 2/2: | Commonly metabolic cause (Sepsis; DKA) |
Apneustic = | Rare, but usually associated with pontine infarction; pt breathes in, holds breath 15-20 sec, breathes out |
Ataxic breathing (Biot's respiration) | Damage to the medullary respiratory centers; breathing slows; long breathless pause; then inhales; this is often premorbid |
Most common reason for noting unreactive pupils: | an inadequate light source |
Reactive pupils = | midbrain is intact |
Intact pupillary responses in unresponsive pt w/ absent EOM & corneal responses: | metabolic (e.g., hypoglycemia) or drug ingestion (e.g., barbiturate) |
Midposition (3-5mm) nonreactive pupils = | midbrain damage |
Blown pupil = | unilaterally dilated, nonreactive pupil: sx of CN III (oculomotor nerve) compression (Aneurysm, Mass Lesion); dilated nonreactive pupil may also be 2/2 DM or drugs (atropine, scopolamine) |
Small, reactive pupils: seen in: | pontine damage (infarct or hemorrhage) or with some drug use (opiates, pilocarpine). |
Bilateral midposition unreactive pupils: | hypothermia |
Eye deviation occurs in what direction? | toward a unilateral hemispheric lesion and away from a unilateral brainstem lesion |
Functional testing of eye movements is done by: | oculo-cephalic reflex (Doll's head) or oculo-vestibular reflex (ice water calorics) |
Oculo-cephalic reflex (Doll's head): CI if: | if there is a question of cervical spine injury |
Oculo-cephalic reflex: Abnormal response = | absent or asymmetric eye movement: destructive lesion at midbrain or pontine level; poss also deep barbiturate poisoning |
Oculo-vestibular reflex: Normal response (conscious pt): | Tonic (sustained) deviation of eyes toward stimulated side, w/ quick phase of nystagmus toward the opposite side |
Oculo-vestibular reflex: Response in comatose pt w/ intact brainstem: | Tonic deviation of eyes, but no nystagmus |
Oculo-vestibular reflex: Response in comatose pt w/ brainstem dysfn: | Loss of tonic deviation w/ stimulation of one, or both ears; if there is no tonic deviation there can be no fast response |
Oculo-vestibular response does not distinguish between: | metabolic and structural causes of coma |
Corneal sensation: | carried by CN V (Trigeminal); test with cotton swab pressed gently onto cornea; abnormal reponse suggests a pontine lesion |
GCS: 3 tests | Eye, verbal, motor; range: 3-15; <8 means coma |
ALS: Dx criteria | UMN & LMN sx in 3 regions; UMN: clinical; LMN: EMG; CK nml or high |
Primary lateral sclerosis: path | degeneration of lateral corticospinal tract |
Primary lateral sclerosis clin findings | usu legs before arms; leg weak/stiff; spasticity; ave duration >8 yrs; many pts develop LMN sx & transition to ALS |
progressive muscular atrophy | pure LMN dz; slower progress than ALS; often spares bulbar mx; CK very high |
Kennedy dz genetics | X-linked rec, TNR; mutation in androgen receptor |
Kennedy dz S/S | facial fasciculations, weakness mouth/tongue; dysphagia, limb weakness; gynecomastia, DM, oligospermia |
Disorders of neuromx transmission (NMJ): | MG, LEMS, botulism |
MG: pathophys | Acquired autoimmune: Ach receptor insufficiency |
MG S/S | fluctuating mx weakness (worse w/reps); asymmetric ptosis; tired face, difficulty chewing/swallowing; SOB |
LEMS S/S | usu paraneoplastic (autoimm rare); proximal weakness / autonomic sx (dry mouth); hypo/absent reflexes; voltage gated Ca channel Abs; facilitation w/ RNS |
Botulism MOA | irreversible blockade of Ach release |
Duchenne MD | onset at 3-5 yrs; calf pseudohypertrophy; loss of ambulation by teens; cardiomyopathy; death in 20s |
Emery Dreifuss | Humeroperoneal / scapuloperoneal weakness w/ early contractures (ankle neck elbow); teen onset (very thin); scap winging/deltoid sparing; x linked or auto dom; cardiac conduction block/arrhythmia (need pacemaker) |
Most common MD's | Duchenne/Becker; myotonic; Facioscapulohumeral dystrophy |
Myotonic dystrophy | auto dom; any age; TNR |
Myotonic dystrophy S/S | tenting upper lip; distal weakness; frontal bald; cataracts; conduction block; DM, infertile; cognitive impairment; percussion myotonia |
Autosomal dominant disorders | Huntington, NF1/NF2, spinocerebellar ataxias, familial Alz, CMT |
NF1: manifestations: | hydrocephalus, seizures, learning disabilities, short, lack of GH, precocious puberty, renal artery stenosis |
Auto recessive disorders | PKU, Tay-Sachs, MSUD, Friedreich's, Wilson, homocystinuria, sickle cell |
Wilson manifestations: | hepatolenticular degen (impaired ceruloplasmin synth); presents in teen years (hepatitis); tremor, dysarthria, slow, hoarse, chorea |
X-linked recessive pattern | F-toM trans; M=affected, F=carrier |
X-linked rec dz | Duchenne/Becker MD; Kennedy; adrenoleukodystrophy; Menkes (kinky hair); Lesch-Nyhan; Fragile X |
X-linked dom dz | F-to-F transmission (lethal to males); Rett; Aicardi; Lissencephaly 2 |
Rett dz | Onset 6-18 mos; live to 40s; autism; cardiac & scoliosis |
Mitochondrial dz | multi generations; trans by F only; 1:1 M:F affected; MERRF, MELAS, LHAN, Kearns-Sayre |
MELAS manifestations | 2/2 pt mutation of transfer DNA from leucine; <40 yo; lactic acidosis; HA, stroke, seizure, short; progressive dementia; no tx |
TNR: mode of inheritance | can be multiple modes of inheritance |
TNR dz | Huntington, Fragile X, myotonic dys; Kennedy; spinocerebellar ataxia; Friedreich |
Alz: APOE gene | E2: protective vs Alz; E4: inc risk of dev Alz |
Parkinson dz S/S | usu unilateral onset; resting tremor, slow, cogwheel rigidity, festinating gait, masked facies, postural instability |
Parkinson: TRAP = | Tremor, Rigidity, Akinesia, Postural instability |
Most common genetic form of Parkinson: | PARK8 |
Central cord syndrome S/S | motor deficit in UE > LE; Varying degrees of sensory loss (pain/temp); most common of the incomplete spinal cord lesions (better prognosis) |
Ligamentum flavum buckles into spinal cord => contusion to central regions of spinal cord = | Central cord syndrome |
Anterior cord syndrome S/S | Paraplegia and dissociated sensory loss with loss of pain and temperature sensation; 2/2 infarction of the cord in the region supplied by the anterior spinal artery |
Anterior cord syndrome: what fn is preserved: | Posterior column (position, vibration, deep pressure) preserved |
Brown-Sequard syndrome: cause | Hemisection of the cord; From penetrating injuries; Rare |
Brown-Sequard syndrome S/S | Ipsilateral motor loss w/loss of vibration, pressure, proprioception; contralateral loss of pinprick, pain, temperature sensations |
Progressive demyelinating; brain, sp cord, optic n.; viral; F>M, peak 20-40yo | MS |
Bell palsy sx | Abrupt onset upper & lower (ipsilateral) facial paresis/ paralysis, mastoid pain, hyperacusis, dry eyes, altered taste; ipsilat ear pain may precede |
LP w/ decreased glucose, increased protein | Bacterial meningitis |
LP w/ decreased protein, very few neutrophils | syphilitic meningitis |
3 mHz spike-and-wave on EEG | Absence (petit-mal) seizures |
Emergent eval of stroke | CBC/plt; PT/ PTT; Lytes, glu, renal; ECG/ markers of cardiac ischemia; Brain CT or MRI |
Atheroembolic stroke dx studies | Normal head CT; Doppler US: high grade stenosis (e.g., L ICA) |
Atheroembolic stroke: dx studies | Neuroimaging; Carotid US; MRA; CTA; Catheter angiography |
Cardioembolic stroke imaging | Carotid US normal (no brain lg vessel prob) |
Cardioembolic stroke: dx studies | pulse; EKG; 24-48 hr EKG; TTE (microcavitation); TEE |
Asymptomatic carotid stenosis: dx studies | Carotid bruit; Doppler US; MRA, CTA |
best modality to distinguish ischemic from hemorrhagic stroke: | CT |
TIA definitive study: | arteriography; MRA more common (less invasive) |
TIA dx studies | CT or MRI to r/o cerebral hemo; cardiac w/u; cbc, esr, coags, antiphospholipids; Poss echo, ecg, carotid doppler |
SAH dx studies | CT (90%); CSF: hi opening P & bloody fluid; cerebral angiography, EEG |
EEG: focal rhythmic discharge at onset, poss no ictal activity seen: | simple partial seizure |
EEG: interictal spikes assoc w/slow waves in temporal/frontotemp | complex partial seizure |
Seizure: labs | Glucose; lytes; AED levels; LP if poss meningitis; EtOH/tox if susp; ABG if susp hypoxia; poss CXR, CT, MRI |
MS: MRI findings | multiple characteristic white matter lesions or plaques: periventricular or subcortical U-fibers, corpus callosum lesions |
MS: CSF findings | oligoclonal bands, increased IgG index, myelin prodn/fragments |
MS: types of dx criteria | Schumacher; Poser: Macdonald |
When do LP? | suspect meningitis; not if suspect abscess |
Glucose depressed: usually: | bac mening, or TB or fungal |
Increased WBC in CSF indicates: | inflammation (not necessarily infection) |
Tuberculous meningitis dx studies | active TB elsewhere in body; CSF inc WBC (100-150), mostly lymphs; abnormal CXR; acid-fast normal |
Ring enhancing lesion is usually: | abscess or tumor |
Symptoms from plateau waves | Transitory episodes of altered consciousness & visual disturbances |
Brain tumor: eval & dx | H&P; CT +/- MRI; EEG; LP; PET |
Brain tumor: VEGF | higher the VEGF, worse the prognosis; anti-VEGF Ab's effective in xenografts |
MRI: T1/T2 | T1: fat bright (water dark); T2: water bright |
quadrigeminal cistern: | should smile |
suprasellar cistern: | (if healthy): resembles a star |
Trauma/Bleeds: imaging of choice | noncontrast CT |
epidural hematoma: appearance on CT | lenticular (biconvex) |
subdural hematoma: appearance on CT | Cross suture lines and extends over larger area; Crescent shaped |
SAH: appearance on CT | Linear, within cisterns and sulci; bleed follows outlines of the gyri |
Normal vertebral disk on MRI: | low T1 signal, High T2 (nuc pulposus is mostly water); normal disks do not extend past margin of vert |
Degenerative disk on MRI: | dehydrates: decreased T2; loses height |
Spinal cord lesion types: | Demyelination; Cysts; Infarction; Tumor |
Demyelination on MRI | patchy T2 signal; may be d/t: MS; Post infectious Myelitis; Compressive Myelopathy; Post Radiation |
Spinal cord infarction on MRI | Gray Matter Affected Preferentially: H-pattern high T2 signal |
Edema on MRI | T1: dark; T2: bright |
Purpose of CT in CVA | Not dx; only to r/o other conditions that would CI some tx (tumor, bleed) |
CVA on CT | Hyperdense artery sign; loss of grey; CT normal up to 12 hours post; insula ribbon sign: blurring of gray-white junction |
Brain neoplasm: imaging of choice | MRI |
Brain neoplasm: imaging | Gray-white matter junction; marked edema; can be multiple, bilateral |
AIDS-related CNS infxn: imaging of choice | MRI; 2/3 develop CNS infxn |
MS imaging | MR sensitive, but not diagnostic; Periventricular T2 bright signal: inflammation |
NPH on CT | Ventriculomegaly out of proportion to sulcal prominence |
Imaging findings assoc w/ 4 stages of brain abscess evolution | early cerebritis (swollen/edema; high T2); late cerebritis (inc central necrosis; vasogenic edema at edges); early capsule; late capsule (well define ring) |
Meningioma: imaging | Often along brain surface; hyperdense, homogeneous enhancement |
Ulnar neuropathy: Dx | Hx; EMG/NCS can help find site of lesion |
Sciatic n. palsy: Dx tests | EMG/NCS (distinguish from peroneal neuropathy); xray |
Charcot-Marie-Tooth Dx: | H&P; DNA testing; Nerve/mx bx (confirmatory); EMG/NCS |
CMT: EMG/NCS | CMT I: segmental demyelination; reduced motor & sensory conduction velocity; CMT II: axonal loss; normal/sl dec motor conduction, dec SNAPs; chronic partial denervation in affected mx |
Dejerine-Sottas Dz: Dx | high CSF pro; EMG/NCS: dec motor velocity, sensory conduction |
Refsum dz: Dx findings | CSF protein normal; nerve bx; EMG/NCS: dec motor velocity, sensory conduction |
Guillain-Barre dx studies | NCS: slow S/M nerve conduction velocities; poss denervation/axonal loss; CSF high pro |
CNS neoplasm CSF | xanthochromic; inc pro, normal cell count & glucose |
MG dx studies | NCS: decrementing mx response; CXR to r/o thymoma; serum acetylcholine Ab |
Wilson: labs | Serum ceruloplasmin (Cu carrying pro) very low; urine Cu high |
Huntington dz on CT | atrophy of cerebrum & caudate nucleus |
Huntington dz on MRI/PET | decreased glucose metab |
Neuroimaging not needed when: | No focal neuro findings; Pt has stable pattern of recurrent HA; No h/o seizures |
HA: Consider neuroimaging when: | Neuro exam abnormal; progressively worsening HA; new persistent HA; new, rapid onset HA (thunderclap headache); HA does not respond to standard tx |
Use LP only after: | normal CT obtained & platelet count is normal |
LP should be performed if: | Neuroimaging is normal or suggests dz that must be dx by measuring cerebrospinal fluid (CSF) pressure, cell count, and chem |
lemon sign on US | Myelomeningocele: 2 frontal bones appear convex inward |
banana sign on US | Myelomeningocele: elongated and curved posterior fossa 2/2 Chiari malformation |
5 steps to dx & tx pt w/suspected brain tumor | MRI is TOC to confirm; Pan CT of chest/abd/pelvis to detect other tumors; Bx of distant tumor or Br tumor resection to confirm patho; xrt/CTx for malig; F/U MRI, PET |
Fisher grade is used to: | classify appearance of SAH on scan |
Hunt Hess scale is used to: | classify severity of symptoms in SAH |
Coma: labs | GLUCOSE, lytes, renal, Ca, PO4, ABG, CBC, tox screen; CXR, imaging (after stabilization) |
Diagnostic LP: indications | CNS infxn (meningitis, encephalitis); HA (SAH); Pseudotumor cerebri (idiopathic ICH); MS; Support dx of NPH & predict response to surgical shunting |
LP: CI | Suspected brain / epidural abscess; elevated ICP, esp if papilledema; suspect mass lesion; Ventricular obstn; |
LP: insert needle into: | L3-L4 space (elderly: may need to do cisternal procedure) |
LP in kids: | spinal cord extends more caudally, do low LP |
CSF collection: amount: | 1-2 mL CSF per tube |
Routine CSF analysis includes: | Opening pressure; Appearance/color; Consistency; Tendency to clot; Diff cell count; Protein; Glucose |
CSF cloudy = | Inc WBC or protein |
CSF: Xanthochromia (yellow tinge) = | hyperbilirubinemia, hypercarotenemia, melanoma |
CSF: Red tinge = | Blood from bleeding into SA space or traumatic tap |
CSF: Cells | Normal 0-5 small lymphs/ml; PMNs, lg monos & RBCs are never normal |
CSF: RBCs & WBCs: | only present via ruptured blood vessels or by meningeal response to inflammation or irritation |
WBC in CSF | Inc WBCs = inflam (>100, prob infxn); PMNs: bac infxn; Lymphs = viral or other (TB, fungal, ca); Eosinophils: shunt, parasitic infection & allergic rxn |
CSF pressure | Normal 60-200 mm H2O (mean = 120); usu drops 5-10 mm for each ml CSF removed |
CSF pressure: Marked elevation: | poss purulent meningitis or intracranial tumors |
CSF pressure: Moderate elevation: | mild inflammation, encephalitis, neurosyphilis |
CSF pressure: Elevated pressure with normal CSF: | confirms pseudotumor cerebri (benign ICH): one instance where LP is done despite presence of papilledema |
CSF protein: increased in: | inc permeability of blood-CSF barrier (tumor, trauma, inflam), or increased intrathecal synthesis of Igs |
CSF protein: decreased in: | CSF protein leak, hyperthyroidism, water intoxication |
CSF glucose | Normal CSF glu 60-70% of plasma glu; Low levels assoc w/ bacterial or TB infection |
CSF lactate: | usu parallels blood levels; if markedly different from blood level = biochem abnormality in CSF |
Increased CSF lactate associated with: | CVA, IC bleed, bacterial meningitis; Not altered in viral meningitis; lactate may differentiate btw viral & bacterial |
Organism conc required for detection on CSF smear: | 10,000/ /ml (Gram & AFB stains may be neg despite org presence in CSF; cx on several media; consider empiric tx) |
CSF antigen serology: | More rapid, but less specific, than cx; cryptococcal Ag test very specific/accurate |
Primary lateral sclerosis: dx studies | EMG, MRI (br & spcord), LP, evoked potls; B12, Lyme, RPR, long chain fatty acids |
Myasthenia gravis Dx studies | Tensilon test; Ach receptor & MuSK Abs; Repetitive nerve stim; Single fiber EMG; CT Chest to exclude thymoma |
MD: labs/studies | ultrastructural protein abnormalities; mx bx: mx fiber necrosis |
Duchenne/Becker: Dx studies | Mx bx; genetic testing (need complete sequencing); CK sometimes >10,000; FH |
Wilson: dx | high ceruloplasmin & copper; low copper on liver bx; Kayser Fleischer rings |
Duchenne/Becker Dx | genetic testing, elevated CK, EMG |
Alz dx | dx of exclusion (neuropsych eval); MRI/CT: hippocampal atrophy; amyloid on PET (Pittsburgh B); LP: inc tau, dec amyloid-beta 42 |
Pathological hallmark of Parkinson: | Lewy body (alpha-synuclein is main component) |
MELAS dx studies | Mitochondrial inheritance, labs: high pyruvate / lactate; stroke lesions (don't conform to normal vasc distn) |
Pseudoseizure | Clinically resembles seizure; does not have EEG evidence of seizure, or respond to epilepsy meds |
NCS | uses electrodes; record response to shock (amp & timing) |
EMG | uses needle; electrical activity observed during rest & activitation |
NCS / EMG utility: | suspicion of peripheral nerve or mx injury; detect CTS; investigate polyneuropathy /poss etiology or radiculopathy |
Evoked potential studies | to study conduction of CNS pathways; electrodes on scalp; brain potentials recorded in response to stim |
Evoked potential studies: 3 kinds: | Visual; Brainstem (auditory); Somatosensory |
Evoked potential studies: useful to dx: | MS (VEP, SSEP), spinal cord diseases |
Visual evoked potential: optic neuritis: | After optic neuritis, the VEP will often remain abnormal indefinitely even after recovery of vision |
SSEP | record potentials from stimulus at wrist or ankle |
Blood EtOH usu measured on: | whole blood (serum levels 12% higher than whole blood) |
Chronic alcohol use: labs | macrocytosis; anemia (later); high AST, ALT, GGT, CDT |
Urine drug test methods | Immunoassay; GC-MS (HPLC) |
Drug test: Immunoassay | fast; large-scale screening; false pos & req confirm by HPLC |
Drug test: HPLC | accurate; time consuming; expensive |
Opiates | Natl: heroin & hydrocodone; synthetic: meperidine & methadone (less detectable) |
Drug with longest detection time: | Benzo or THC |
Drugs with lowest/highest detection thresholds: | Lowest: THC; highest: amphetamine |
oligoclonal bands in CSF = | MS |
Acoustic neuroma (vestibular schwannoma): dx with: | CT or MRI; surgical tx |